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Cholangiocarcinoma manifesting as non-bacterial thrombotic endocarditis in a young patient
A 41-year-old female with steroid-dependent rheumatoid arthritis and a recent (four months prior) cerebellar stroke presented with complaints of constant headache and right eye blindness of one day.  At the time of the cerebellar stroke, she had presented with persistent headaches, dizziness and gait instability. That workup, including hypercoagulability evaluation, was unremarkable apart from the radiographic abnormalities diagnosing her left medial cerebellar hemisphere infarct. She was disc harged with a plan for outpatient loop recorder placement and aspirin for secondary stroke prevention.
Source: The American Journal of Medicine - January 23, 2020 Category: General Medicine Authors: Ninad Nadkarni, Young Ju Lee, Ryan Hoefen, Richard Alweis Tags: Diagnostic Dilemma Source Type: research

Severe thrombosis of bioprosthesis mitral valve after dabigatran.
Abstract A 41-year-old female was admitted to our hospital with an unidentified source of fever, dyspnea and dizziness. Transthoracic echocardiography demonstrated severe mitral valve regurgitation, and further examination with transesophageal echocardiography (TEE) revealed a 7 mm vegetation on the anterior mitral leaflet. Blood cultures were negative, and after 45 days of empiric 12 g/day ampicillin-sulbactam therapy, the vegetation was shown to have disappeared. However, due to ongoing severe mitral regurgitation and valve deformity, a prosthetic metallic mitral valve replacement was performed. After the operat...
Source: Turk Kardiyoloji Dernegi arsivi - September 1, 2013 Category: Cardiology Authors: Akgüllü C, Eryılmaz U, Kurtoğlu T Tags: Turk Kardiyol Dern Ars Source Type: research

CardioPulse Articles * Warfarin increases stroke risk in atrial fibrillation * Aspirin still overprescribed for stroke prevention in atrial fibrillation * Clinical Research in Cardiology: the official journal of the German Cardiac Society (Deutsche Gesellschaft fur Herz-/Kreislaufforschung) * Septic shock in infective endocarditis * Innovation in atrial fibrillation therapy
Source: European Heart Journal - June 7, 2014 Category: Cardiology Tags: CardioPulse Source Type: research

Heparin, grad students, a clinical revolution and giving credit where it's due
The story of a grad student who overcame remarkable odds only to be denied his moment of glory, or a tale of dark deceit and devilish doings? The story of heparin is as complicated as the chemistry itselfBlood is remarkable.A liquid that carries nutrients, waste products and the ever-vigilant cells of the immune system around the body, blood rapidly turns into a solid when it leaves its veins and arteries and becomes exposed to bodily tissues or the air outside. This process of solidification – clotting, or coagulation – is executed and controlled by a complex set of reactions and interactions primarily involving the e...
Source: Guardian Unlimited Science - September 4, 2013 Category: Science Authors: Richard P Grant Tags: theguardian.com Blogposts Science Source Type: news

A Rare Cause of Life-Threatening Upper Gastrointestinal Bleeding
Question: A 66-year-old woman presented to the hospital with large-volume hematemesis and melena. Her past medical history was significant for an episode of native valve infective endocarditis secondary to a skin infection 4 years earlier, with an associated embolic stroke of the left middle cerebral artery. Her daily medications included aspirin and atorvastatin. She denied any intake of other non-steroidal anti-inflammatory drugs. She had no history of peptic ulcer disease or liver disease. On arrival to the hospital, the patient ’s blood pressure was 90/60 mm Hg, with a heart rate of 140 beats/min.
Source: Gastroenterology - May 26, 2023 Category: Gastroenterology Authors: Howard Guo, Jesse Stach, Paul J. Belletrutti Tags: Electronic Curbside Consult Source Type: research