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Condition: Cardiomyopathy
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Total 155 results found since Jan 2013.
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK α/TGF-β/Smad signalling in type 2 diabetic rats
This study aimed to evaluate the effect of SGLT2 inhibitor dapagliflozin (DAPA) on DCM especially for cardiac fibrosis and explore the underlying mechanism. In vivo, the model of type 2 diabetic rats was built with high-fat feeding and streptozotocin injection. Untreated diabetic rats showed cardiac dysfunction, increased myocardial fibrosis and EndMT, which was attenuated after treatment with DAPA and metformin. In vitro, HUVECs and primary cardiac fibroblasts were treated with DAPA and exposed to high glucose (HG). HG-induced EndMT in HUVECs and collagen secretion of fibroblasts were markedly inhibited by DAPA. Up-regula...
Source: J Cell Mol Med - June 25, 2021 Category: Molecular Biology Authors: Jingjing Tian Mingjun Zhang Mengying Suo Dian Liu Xuyang Wang Ming Liu Jinyu Pan Tao Jin Fengshuang An Source Type: research
Targeting TRAF3IP2 alleviates high glucose-induced cardiomyocyte inflammation and apoptosis
Drug Dev Res. 2021 Jul 14. doi: 10.1002/ddr.21856. Online ahead of print.ABSTRACTTo clarify the role of TRAF3IP2 in high glucose (HG)-stimulated cardiomyocyte inflammation and apoptosis and its action mechanism. SiRNA plasmid of TRAF3IP2 was constructed and transfected into HG-stimulated cardiomyocytes to silence TRAF3IP2. The expression of TRAF3IP2 was determined by quantitative polymerase chain reaction (qPCR) and western blot. Cell viability and cytotoxicity were first observed using cell counting kit-8 and lactate dehydrogenase assays. The inflammatory injury of the cardiomyocytes was then examined by real time-qPCR (R...
Source: Cell Research - July 14, 2021 Category: Cytology Authors: Jing Wei Tao Yan Yuanhong Liang Source Type: research
Weighted Gene Co-Expression Network Analysis Identifies ANGPTL4 as a Key Regulator in Diabetic Cardiomyopathy via FAK/SIRT3/ROS Pathway in Cardiomyocyte
ConclusionWe found ANGPTL4, ACOT1, DECR1, HMGCS2, and PDK4 were significantly increased in diabetic heart. ANGPTL4 could promote cardiac apoptosis via a FAK/SIRT3/ROS dependent signaling pathway in DbCM.
Source: Frontiers in Endocrinology - September 20, 2021 Category: Endocrinology Source Type: research
GSE180248 Transcriptomic analysis of HDAC6-selective and broad HDAC inhibitors in human WT iPSC cardiomyocytes
Contributors : Jin Yang ; Francis Grafton ; Ana Budan ; Sara Ranjbarvaziri ; Farshad Farshidfar ; Marie Cho ; Emma Xu ; Jaclyn Ho ; Mahnaz Maddah ; Kevin E Loewke ; Julio Medina ; David Sperandio ; Snahel Patel ; Tim Hoey ; Mohammad A MandegarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying molecular mechanisms associated with genetic forms...
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE179656 Phenotypic Screening with Deep Learning Identifies HDAC6 Inhibitors as Cardioprotective Agents in Mouse Models of Dilated Cardiomyopathy
Contributors : Jin Yang ; Francis Grafton ; Ana Budan ; Sara Ranjbarvaziri ; Farshad Farshidfar ; Marie Cho ; Emma Xu ; Jaclyn Ho ; Mahnaz Maddah ; Kevin E Loewke ; Julio Medina ; David Sperandio ; Snahel Patel ; Tim Hoey ; Mohammad A MandegarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying molecular mechanisms associated with genetic forms...
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy
This article is protected by copyright. All rights reserved.PMID:35502635 | DOI:10.1111/imm.13490
Source: Immunology - May 3, 2022 Category: Allergy & Immunology Authors: Rico Feldtmann Andreas K ümmel Bishwas Chamling Anne Strohbach Kristin Lehnert Stefan Gross Lisa Loerzer Alexander Riad Diana Lindner Dirk Westermann Jens Fielitz Marcus D örr Stephan B Felix Source Type: research
Gasdermin D mediates doxorubicin- induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage
Transl Res. 2022 May 8:S1931-5244(22)00100-1. doi: 10.1016/j.trsl.2022.05.001. Online ahead of print.ABSTRACTDoxorubicin (Dox), as a widely used anthracycline antitumor drug, can cause severe cardiotoxicity. Cardiomyocyte death and inflammation are involved in the pathophysiology of Dox-induced cardiotoxicity (DIC). Gasdermin D (GSDMD) is known as a key executioner of pyroptosis, which is a pro-inflammatory programmed cell death. We aimed to investigate the impact of GSDMD on DIC and systematically reveal its underlying mechanisms. Our findings indicated that Dox induced cardiomyocyte pyroptosis in a GSDMD-dependent manner...
Source: Translational Research : the journal of laboratory and clinical medicine - May 11, 2022 Category: Laboratory Medicine Authors: Bozhi Ye Xiaowen Shi Jianjiang Xu Shanshan Dai Jiajun Xu Xiaoxi Fan Bingjiang Han Jibo Han Source Type: research
