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Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis
In conclusion, these data suggest that MEK-ERK1/2 signaling pathway facilitates IBV infection, probably by promoting cell survival; meanwhile, induction of DUSP6 forms a negative regulation loop to restrict ERK1/2 signaling, correlated with increased apoptosis and reduced viral load. Consequently, components of the ERK pathway, such as MEK1/2 and DUSP6, represent excellent targets for the development of antiviral drugs.
Source: Veterinary Research - January 11, 2021 Category: Veterinary Research Source Type: research

Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

LSC - 2017 - The role of the epigenetic regulator HMGN5 in COPD resulting from chronic lung injury
COPD, characterized by chronic bronchitis, small airway remodeling and emphysema, is one of the leading causes of chronic morbidity and mortality worldwide. Chronic lung injury, commonly caused by cigarette smoking (CS), is a major factor in its development. A role for epigenetics in this underlying pathology is emerging. We previously detected spontaneous emphysema in HMGN5-/-mice. HMGN5 binds to the nucleosomal core particle of chromatin, competing with histone H1, altering chromatin structure and affecting cellular transcription, differentiation and repair. Indeed, increased expression of HMGN5 has been observed in lung...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Gunes, G., Conlon, T., Sarker, R., Burgstaller, G., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., Furusawa, T., Bustin, M., Eickelberg, O., Önder Yildirim, A., Dorer, J. Tags: Molecular Pathology and Functional Genomics Source Type: research

Brain-Derived Neurotrophic Factor in Cigarette Smoke-Induced Airway Hyperreactivity.
Abstract Enhanced airway smooth muscle (ASM) contractility contributes to increased resistance to airflow in diseases such as bronchitis and asthma that occur in passive smokers exposed to secondhand smoke. Currently, little information exists on the cellular mechanisms underlying such airway hyperreactivity. Sputum samples of patients with chronic sinusitis, bronchitis and asthma show increased levels of growth factors called neurotrophins, including brain-derived growth factor (BDNF), but their physiological significance is not known. In human ASM, we tested the hypothesis that BDNF contributes to increased cont...
Source: American Journal of Respiratory Cell and Molecular Biology - December 20, 2012 Category: Molecular Biology Authors: Sathish V, Vanoosten SK, Miller BS, Aravamudan B, Thompspon MA, Pabelick CM, Vassallo R, Prakash YS Tags: Am J Respir Cell Mol Biol Source Type: research