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Specialty: Psychiatry
Condition: Alzheimer's

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Total 197 results found since Jan 2013.

Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury.
Authors: Greig NH, Tweedie D, Rachmany L, Li Y, Rubovitch V, Schreiber S, Chiang YH, Hoffer BJ, Miller J, Lahiri DK, Sambamurti K, Becker RE, Pick CG Abstract Traumatic brain injury (TBI), either as an isolated injury or in conjunction with other injuries, is an increasingly common event. An estimated 1.7 million injuries occur within the USA each year and 10 million people are affected annually worldwide. Indeed, nearly one third (30.5%) of all injury-related deaths in the USA are associated with TBI, which will soon outpace many common diseases as the major cause of death and disability. Associated with a high mo...
Source: The Journal of Alzheimers Association - February 18, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Development and validation of a brief dementia screening indicator for primary care.
CONCLUSIONS: The Dementia Screening Indicator is a simple tool that may be useful in primary care settings to identify high-risk patients to target for cognitive screening. PMID: 24491321 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - February 7, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Memantine for Lewy Body Disorders: Systematic Review and Meta-Analysis.
CONCLUSION: Our results suggest that memantine did not have a benefit for the treatment of Lewy body disorders in cognition and motor function. However, memantine may be superior to placebo for the overall impression of the disorders. Further, memantine is well tolerated. PMID: 24406251 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - January 11, 2014 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Vascular Risk Factors and Cognitive Decline in a Population Sample.
We examined several vascular factors in relation to the rates of decline in 5 cognitive domains in a population-based cohort. In an age-stratified random sample (N=1982) aged 65+ years, we assessed at baseline the cognitive domains of attention, executive function, memory, language, and visuospatial function, and also vascular, inflammatory, and metabolic indices. Random effects models generated slopes of cognitive decline over the next 4 years; linear models identified vascular factors associated with these slopes, adjusting for demographics, baseline cognition, and potential interactions. Several vascular risk factors (h...
Source: Alzheimer Disease and Associated Disorders - October 16, 2013 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Revisiting the framework of the National Institute on Aging-Alzheimer's Association diagnostic criteria.
Authors: Carrillo MC, Dean RA, Nicolas F, Miller DS, Berman R, Khachaturian Z, Bain LJ, Schindler R, Knopman D Abstract In 2011, the National Institute on Aging and the Alzheimer's Association (NIA-AA) proposed revising the criteria for diagnosing Alzheimer's disease (AD), which had been established more than 25 years earlier by the National Institute on Neurologic and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's Disease and Related Disorders Association (ADRDA), now called the Alzheimer's Association. The NIA-AA initiative also built upon research criteria for AD proposed by the International W...
Source: The Journal of Alzheimers Association - September 7, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Midlife Cardiovascular Risk Impacts Executive Function: Framingham Offspring Study.
CONCLUSIONS:: For those middle-aged and healthy, including those who are ApoE4+, cardiovascular risk factors are related to impairments in EF as ascertained by novel errors and traditional measures. PMID: 23995818 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - September 3, 2013 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Increased risk of dementia in people with previous exposure to general anesthesia: A nationwide population-based case-control study.
CONCLUSIONS: A history of previous exposure to surgery under GA might be associated with an increased risk of dementia, particularly in subjects who have undergone repeated exposure to GA. In addition, subjects who had received surgery under ETGA with comorbidities such as stroke, hypertension, diabetes mellitus, and atherosclerosis could have a potential relationship with dementia risk. PMID: 23896612 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - July 31, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Mild Cognitive Impairment, Risk Factors and Magnetic Resonance Volumetry: Role of Probable Alzheimer's Disease in the Family.
Conclusions: Our findings suggest that research on Hcy, cardiovascular risk factors and other potential risk factors for LOAD might benefit from distinguishing between sporadic and familial LOAD. PMID: 23797189 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - June 26, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Could Antibodies or Hormones Slow Brain Damage from Alzheimer’s?
Scientists have discovered that certain antibodies may help slow the progression of Alzheimer’s disease. Dr. Patricia Salinas of University College London, UK, and her team focused on a protein called Dkk1, present in raised levels in the brains of people with Alzheimer’s disease. Using brain samples from mice, the team looked at the progressive disintegration of synapses in the hippocampus when exposed to a protein called amyloid-beta, thought to be central to the development of Alzheimer’s disease. “Synaptic loss mediated by amyloid-beta in early stages of the disease might contribute to cognitive...
Source: Psych Central - June 1, 2013 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Disorders General Seniors Abnormal Deposits Alzheimer S Disease Antibodies Brain Area Brain Damage Cognitive Decline Cognitive Impairments Disintegration Dr Patricia Dr Simon Hippocampus Journal Of Neurosc Source Type: news

Table of Contents
Abstract Study of antidepressants finds modest effect on QT prolongation Reckitt blocked by FDA on buprenorphine, faces FTC inquiry SSRIs and tramadol: Possible link to serotonin syndrome Orexin receptor antagonist effective for insomnia Antipsychotics' receptor profiles linked to stroke risk FDA offers new guidance on developing drugs for Alzheimer's disease Common genetic variation and antidepressant efficacy Antipsychotics and weight change Pharmacogenetic study looks at cocaine abuse Polymorphism predicts escitalopram dose for depression D‐cycloserine impact on fear examined SSRI drugs and ischemic heart disease and ...
Source: The Brown University Psychopharmacology Update - April 9, 2013 Category: Psychiatry Source Type: research

2013 Alzheimer's disease facts and figures.
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long-distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom ...
Source: The Journal of Alzheimers Association - March 20, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Course and etiology of dysexecutive MCI in a community sample.
CONCLUSIONS: dMCI appears to follow a different course, and is less associated with Alzheimer's disease and more associated with stroke than aMCI. PMID: 23452959 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - March 9, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Rapid-onset Apathy May Be the Only Clinical Manifestation After Dorsal Striatum Hemorrhagic Lesion: A Case Report.
Authors: Spalletta G, Cravello L, Piras F, Iorio M, Sancesario G, Marchi A, Caltagirone C, Cacciari C Abstract Apathy is a common clinical feature of stroke patients and it is often correlated with cognitive deficits, functional impairment and depression. Here we report the case of a 70-year-old woman with no history of neuropsychiatric disorders who showed abrupt onset of pure apathy after the onset of a right brain vascular lesion located in the head of the caudate nucleus, the anterior part of the putamen, and the genu and the anterior limb of the internal capsule. A complete neuropsychological and neurological ...
Source: Alzheimer Disease and Associated Disorders - March 9, 2013 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Translating current knowledge into dementia prevention.
Authors: Román GC, Nash DT, Fillit H Abstract Considerable knowledge has been gained from epidemiologic studies and randomized clinical trials regarding risk factors for dementia, including Alzheimer disease (AD) and vascular dementia (VaD). Most identified risk factors for dementia are similar to vascular disease risk factors for heart disease and stroke. In 2010, the National Institutes of Health Conference concluded that there are no validated modifiable factors to reduce the incidence of AD or to change its course. This research perspective specifically concerning AD disregards the fact that in community-dwell...
Source: Alzheimer Disease and Associated Disorders - March 9, 2013 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Body Height and Late-Life Cognition Among Patients With Atherothrombotic Disease.
CONCLUSIONS:: Among our sample of coronary heart disease patients, a higher stature is associated with a lower risk of impairment in the visual-spatial function and with better cognitive performance. PMID: 22683666 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - March 9, 2013 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research