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The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research

Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research

Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer & rsquo;s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids Molecules doi: 10.3390/molecules28155624 Authors: Ryszard Pluta Barbara Miziak Stanisław J. Czuczwar Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation, oxidative stress, vasoconstriction, cerebral amyloid angiopathy,...
Source: Molecules - July 25, 2023 Category: Chemistry Authors: Ryszard Pluta Barbara Miziak Stanis ław J. Czuczwar Tags: Review Source Type: research

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms
Int J Mol Sci. 2023 Mar 28;24(7):6328. doi: 10.3390/ijms24076328.ABSTRACTNeuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing brain damage and contributing to the onset and progression of various brain diseases. Therefore, understanding neuroinflammation mechanisms and developing strategies to control them is crucial for treating brain diseases. Studies have shown that neuroinflammation plays a vital role in the progression of neurodegenerative diseases, such as Alzheimer'...
Source: Cancer Control - April 13, 2023 Category: Cancer & Oncology Authors: Ming-Chang Chiang Tsung-Yu Tsai Chieh-Ju Wang Source Type: research

Moschus exerted protective activity against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced cell injury in PC12 cells through regulating Nrf-2/ARE signaling pathways
Biomed Pharmacother. 2023 Jan 26;159:114290. doi: 10.1016/j.biopha.2023.114290. Online ahead of print.ABSTRACTThe pivotal characteristics of Alzheimer's disease (AD) are irreversible memory loss and progressive cognitive decline, eventually causing death from brain failure. In the various proposed hypotheses of AD, oxidative stress is also regarded as a symbolic pathophysiologic cascade contributing to brain diseases. Using Chinese herbal medicine may be beneficial for treating and preventing AD. As a rare and valuable animal medicine, Moschus possesses antioxidant and antiapoptotic efficacy and is extensively applied for ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 28, 2023 Category: Drugs & Pharmacology Authors: Danni Xie Ting Deng Zhenwei Zhai Tao Qin Caiyou Song Ying Xu Tao Sun Source Type: research

Neuroprotective Potency of Safranal Against Neurological Disorders
Curr Mol Med. 2022 Nov 17. doi: 10.2174/1566524023666221117104612. Online ahead of print.ABSTRACTA great number of research has been focused on plants as a source of medicine against many diseases to overcome the many side effects of chemical drugs. Safranal, one of the main constituents of saffron [Crocus sativus], has a broad spectrum of pharmacological effects, including anti-inflammatory, antioxidant, and antiapoptotic effects. The present review elaborates on the current understanding of the neuroprotective effects of safranal. According to data published so far, safranal has the potential to exert neuroprotective eff...
Source: Current Molecular Medicine - November 18, 2022 Category: Molecular Biology Authors: Elham Fazeli Mohammad Hossein Eshaghi Ghalibaf Fatemeh Forouzanfar Source Type: research

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