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Total 258 results found since Jan 2013.
Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using < em > Perilla frutescens < /em > Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.PMID:37687260 | DOI:10.3390/molecules28176431
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Source Type: research
Phytochemical investigation, antioxidant, anti-inflammatory and cytotoxic activities of Tunisian medicinal < em > Tamarix africana Poir < /em >
In this study, novel biological activities of the shoot extracts related to their phenolics investigated. Secondary metabolite contents, antioxidant, anti-inflammatory and cytotoxic activities of four extracts (hexane, dichloromethane, methanol and water) were investigated. Antioxidant activities were assessed via in vitro and ex vivo assays. Besides, anticancer activity was investigated against human lung carcinoma (A-549) and colon adenocarcinoma (DLD-1) cells. The anti-inflammatory ability was evaluated via inhibition of LPS-induced NO production in RAW 264.7 macrophage cell lines. Methanol and water extracts displayed ...
Source: Cell Research - August 31, 2023 Category: Cytology Authors: Manel Karker Samia Oueslati Hanen Falleh Kamel Msaada Jean Legault Chedly Abdelly Andr é Pichette Riadh Ksouri Source Type: research
Water-Soluble Alkali Lignin as a Natural Radical Scavenger and Anticancer Alternative
Int J Mol Sci. 2023 Aug 11;24(16):12705. doi: 10.3390/ijms241612705.ABSTRACTSeveral phytochemicals, which display antioxidant activity and inhibit cancer cell phenotypes, could be used for cancer treatment and prevention. Lignin, as a part of plant biomass, is the second most abundant natural biopolymer worldwide, and represents approximately 30% of the total organic carbon content of the biosphere. Historically, lignin-based products have been viewed as waste materials of limited industrial usefulness, but modern technologies highlight the applicability of lignin in a variety of industrial branches, including biomedicine....
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Donika Ivanova Galina Nikolova Yanka Karamalakova Severina Semkova Vania Marutsova Zvezdelina Yaneva Source Type: research
Enhancing Healthcare Outcomes and Modulating Apoptosis- and Antioxidant-Related Genes through the Nano-Phytosomal Delivery of Phenolics Extracted from < em > Allium ampeloprasum < /em >
In this study, a novel nano-phytosome-loaded phenolic rich fraction (PRF) derived from Allium ampeloprasum L. was developed. The antitumor activity of the formulation was evaluated in BALB/c mice with TUBO colon carcinoma. The PRF-loaded nano-phytosome (PRF-NPs) exhibited a sphere-shaped structure (226 nm) and contained a diverse range of phenolic compounds. Animal trials conducted on TUBO tumor-bearing mice demonstrated that treatment with PRF-NPs at a dosage of 50 mg TPC/Kg/BW resulted in significant improvements in body weight and food intake, while reducing liver enzymes and lipid peroxidation. The expression of apopto...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Ali Shoeibi Ehsan Karimi Mohsen Zareian Ehsan Oskoueian Source Type: research
Molecular dissection of anti-colon cancer activity of NARI-29: Special focus on H < sub > 2 < /sub > O < sub > 2 < /sub > modulated NF- κB and death receptor signaling
Free Radic Res. 2023 Jul 31:1-20. doi: 10.1080/10715762.2023.2243029. Online ahead of print.ABSTRACTAccumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are the main factor responsible for cancer progression and drug resistance. Epalrestat is the only AR inhibitor being used in Asian countries. It did not make it to the markets of the USA and Europe due to marginal efficacy as an antioxidant and anti-inflammatory agent owing to difficulty reaching intracellular targets. In our previous studies, we attempted to synthesize the epalrestat analogs and reported that the com...
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Syamprasad Np Bishal Rajdev Siddhi Jain Jagadeesh Kumar Gangasani Jayathirtha Rao Vaidya Vgm Naidu Source Type: research
The potential therapeutic effects of Galbanic acid on cancer
Pathol Res Pract. 2023 Jul 13;248:154686. doi: 10.1016/j.prp.2023.154686. Online ahead of print.ABSTRACTGalbanic acid (GBA), as a natural compound has potential anticancer properties. It has been documented that GBA shows promising therapeutic potential against various types of cancer, including breast, lung, colon, liver, and prostate cancer. Several mechanisms involve im anti-tumor effects of GBA include apoptosis induction, cell cycle arrest, inhibition of angiogenesis, suppression of metastasis, and modulation of immune responses. Furthermore, the synergistic effects of GBA along with chemotherapeutic agents led to has...
Source: Pathology, Research and Practice - July 24, 2023 Category: Pathology Authors: Elahe Raji Vahid Vahedian Pezhman Golshanrad Reza Nahavandi Parisa Behshood Nahal Soltani Mahdi Gharibi Mohsen Rashidi Nazila Fathi Maroufi Source Type: research
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives
Eur J Med Chem. 2023 Jul 18;259:115662. doi: 10.1016/j.ejmech.2023.115662. Online ahead of print.ABSTRACTTwo series of NSAIDs-EBS derivatives (5a-j and 9a-i) based on the hybridization of nonsteroidal anti-inflammatory drugs (NSAIDs) skeleton and Ebselen moiety were synthesized. Their cytotoxicity was evaluated against five types of human cancer cell lines, BGC-823 (human gastric cancer cell line), SW480 (human colon adenocarcinoma cells), MCF-7 (human breast adenocarcinoma cells), HeLa (human cervical cancer cells), A549 (human lung carcinoma cells). Moreover, the most active compound 5j showed IC50 values below 3 μM in ...
Source: European Journal of Medicinal Chemistry - July 23, 2023 Category: Chemistry Authors: Min Zhong Ying Lu Shaolei Li Xiaolong Li Zhenming Liu Xianran He Yongmin Zhang Source Type: research
Phytochemical profiling, antimicrobial, antiproliferative and apoptotic effects of Stemodia viscosaRoxb.of Western Ghats region, India
Chem Biodivers. 2023 Jul 18:e202300332. doi: 10.1002/cbdv.202300332. Online ahead of print.ABSTRACTThe present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. 13 bioactive compounds were identified in the 80% ethanolic extract by GC-MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 µg QE/mg DW and 89.31 µg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50 = 9.96 µg/ mL). The 80% ethanolic extract exhibited significant antimicrobial activit...
Source: Chemistry and Biodiversity - July 18, 2023 Category: Biochemistry Authors: Prashant Vikramrao Anbhule Alfredi Alfred Moyo Kishor Sambhaji Jagadhane Snahe Raghunath Bhosale Devashree N Patil Vinod B Shimpale Source Type: research
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pharmacological updates of nifuroxazide: Promising preclinical effects and the underlying molecular mechanisms
Eur J Pharmacol. 2023 May 14:175776. doi: 10.1016/j.ejphar.2023.175776. Online ahead of print.ABSTRACTNifuroxazide (NFX) is a safe nitrofuran antibacterial drug used clinically to treat acute diarrhea and infectious traveler diarrhea or colitis. Recent studies revealed that NFX displays multiple pharmacological effects, including anticancer, antioxidant, and anti-inflammatory effects. NFX has potential roles in inhibiting thyroid, breast, lung, bladder, liver, and colon cancers and osteosarcoma, melanoma, and others mediated by suppressing STAT3 as well as ALDH1, MMP2, MMP9, Bcl2 and upregulating Bax. Moreover, it has prom...
Source: European Journal of Pharmacology - May 16, 2023 Category: Drugs & Pharmacology Authors: Hanan S Althagafy MostafaK Abd El-Aziz Islam M Ibrahim Esraa K Abd-Alhameed EmadH M Hassanein Source Type: research
