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Cancer: Colon Cancer
Drug: Insulin
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Total 160 results found since Jan 2013.
Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
The association of diet-dependent acid load with colorectal cancer risk: a case-control study in Korea
We examined whether colorectal carcinogenesis is attributable to a diet with a high acid load. We recruited a total of 923 CRC cases and 1846 controls at the National Cancer Center in Korea for inclusion in a case-control study. We collected information on nutrient intake and specific clinical parameters of CRC by using a semiquantitative food frequency questionnaire and medical records, respectively. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) were used to estimate diet-dependent acid load. We used an unconditional logistic regression model to analyse the association. Dietary acid load score...
Source: The British Journal of Nutrition - August 31, 2023 Category: Nutrition Authors: Tao Thi Tran Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
An overview of recent findings that shed light on the connection between fat and cancer
Endocr Metab Immune Disord Drug Targets. 2023 Jul 24. doi: 10.2174/1871530323666230724141942. Online ahead of print.ABSTRACTObesity and cancer have been found to have a direct link in epidemiological studies. Obesity raises the risk of cancer and associated chronic disorders. Furthermore, an imbalance of adipokines, like leptins, plays a crucial role in neoplasm pathogenesis, cell migration, and thereby, cancer metastasis. Also, leptin increases human epidermal growth factor receptor 2 (HER2) protein levels through the STAT3-mediated (signal transducer and activator of transcription) upregulation of heat shock protein (Hsp...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 25, 2023 Category: Endocrinology Authors: Parth Pandit Chaitanya Shirke Nirav Bhatia Angel Godad Sateesh Belemkar Jayshree Patel Sandip Zine Source Type: research
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting beta-catenin signaling for prevention of colorectal cancer - Nutraceutical, drug, and dietary options
Eur J Pharmacol. 2023 Jul 20:175898. doi: 10.1016/j.ejphar.2023.175898. Online ahead of print.ABSTRACTProgressive up-regulation of β-catenin signaling is very common in the transformation of colorectal epithelium to colorectal cancer (CRC). Practical measures for opposing such signaling hence have potential for preventing or slowing such transformation. cAMP/PKA activity in colon epithelium, as stimulated by COX-2-generated prostaglandins and β2-adrenergic signaling, boosts β-catenin activity, whereas cGMP/PKG signaling has the opposite effect. Bacterial generation of short-chain fatty acids (as supported by unrefined h...
Source: European Journal of Pharmacology - July 22, 2023 Category: Drugs & Pharmacology Authors: Simon Bernard Iloki Assanga Lidianys Mar ía Lewis Luján Mark F McCarty Source Type: research
The Role of Gut Microbiome-Derived Short Chain Fatty Acid Butyrate in Hepatobiliary Diseases
Am J Pathol. 2023 Jul 6:S0002-9440(23)00238-9. doi: 10.1016/j.ajpath.2023.06.007. Online ahead of print.ABSTRACTThe multiple beneficial effects of the short-chain fatty acid (SCFA) butyrate on human health, produced from fermentable carbohydrates by gut microbiota in the colon, are well known. At the intestinal level, butyrate regulates metabolism, helps in the transepithelial transport of fluids, inhibits inflammation, and induces the epithelial defense barrier. The liver receives a large amount of SCFAs along with the blood that travels from the gut via the portal vein. In many recent studies, butyrate has been reported ...
Source: Am J Pathol - July 8, 2023 Category: Pathology Authors: Kishor Pant Senthil K Venugopal Maria J Lorenzo Pisarello Sergio A Gradilone Source Type: research
