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Cancer: Pancreatic Cancer
Drug: Insulin

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Total 317 results found since Jan 2013.

In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research

Identification of quality markers for < em > Cyanotis arachnoidea < /em > and analysis of its physiological mechanism based on chemical pattern recognition, network pharmacology, and experimental validation
In this study, ultra-high-performance liquid chromatography (UHPLC) fingerprint combined with chemical pattern recognition were performed, and four differential components were screened out as quality markers, including 20-Hydroxyecdysone, 3-O-acetyl-20-hydroxyecdysone, Ajugasterone C, and 2-O-acetyl-20-hydroxyecdysone. Network pharmacology analysis revealed 107 therapeutic target genes of Cyanotis arachnoidea in DM treatment, and the key targets were Akt1, TNF, IL-6, MAPK3, and JUN. The hypoglycemic mode of action of Cyanotis arachnoidea may be mediated by tumor necrosis factor (TNF) signaling, cancer, insulin resistance,...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Jingnan Hu Yu Feng Baolin Li Fengxia Wang Qi Qian Wei Tian Liying Niu Xinguo Wang Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The artificial pancreas: two alternative approaches to achieve a fully closed-loop system with optimal glucose control
CONCLUSION: This narrative review presents two lesser-explored viable solutions for AP systems and discusses the potential for improvement toward a fully automated system: A) using the intraperitoneal approach for more rapid insulin absorption, and B) besides using glucagon to treat and prevent hypoglycemia, also administering micro-boluses of glucagon to increase the local SC blood flow, thereby accelerating SC insulin absorption and SC glucose sensor site dynamics.PMID:37715091 | DOI:10.1007/s40618-023-02193-2
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: M K Åm I A Teigen M Riaz A L Fougner S C Christiansen S M Carlsen Source Type: research

TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression
EMBO J. 2023 Sep 15:e113928. doi: 10.15252/embj.2023113928. Online ahead of print.ABSTRACTTo fulfill their function, pancreatic beta cells require precise nutrient-sensing mechanisms that control insulin production. Transcription factor EB (TFEB) and its homolog TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here, we show that TFEB and TFE3 regulate beta-cell function and insulin gene expression in response to variations in nutrient availability. We found that nutrient deprivation in beta cells promoted TFEB/TFE3 activation, which resulted in suppression of insuli...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Adrien Pasquier Nunzia Pastore Luca D'Orsi Rita Colonna Alessandra Esposito Veronica Maffia Rossella De Cegli Margherita Mutarelli Susanna Ambrosio Gennaro Tufano Antonio Grimaldi Marcella Cesana Davide Cacchiarelli Nathalie Delalleau Gennaro Napolitano A Source Type: research

Beta-cell death and dysfunction drives hyperglycaemia in organ donors
CONCLUSIONS: In pancreas donors, hyperglycaemia requiring IT is strongly associated with beta-cell death. This provides an explanation for the relationship of donor IT with post-transplant beta-cell dysfunction in transplant recipients.PMID:37646197 | DOI:10.1111/dom.15248
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Iestyn M Shapey Angela Summers James O'Sullivan Catherine Fullwood Neil A Hanley John Casey Shareen Forbes Miranda Rosenthal Paul R V Johnson Pratik Choudhary James Bushnell James A M Shaw Daniel Neiman Ruth Shemer Benjamin Glaser Yuval Dor Titus Augustin Source Type: research

Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Endocrinology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research

Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway
Food Chem Toxicol. 2023 Aug 19:113997. doi: 10.1016/j.fct.2023.113997. Online ahead of print.ABSTRACTOur previous study demonstrated that Tartary buckwheat root polysaccharides (TBRP) could reduce insulin resistance in diabetes mellitus by inhibiting SOCS3-stimulated IRS1 protein degradation. However, whether TBRP has the efficiency to treat non-alcoholic fatty liver disease (NAFLD) is still undetermined. This investigation aimed to examine the effects of TBRP on a high-fat diet (HFD)-triggered NAFLD, and elucidate the underlying molecular mechanisms. Briefly, TBRP toxicity in hepatoma (BEL7404) and pancreatic cancer (BxPC...
Source: Food and Chemical Toxicology - August 21, 2023 Category: Food Science Authors: Litao Zhang Shuo Wang Yimin Li Boyu Liu Zeyu Duan Fei Liu Qiang Ren Source Type: research

Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes
Front Immunol. 2023 Aug 1;14:1207108. doi: 10.3389/fimmu.2023.1207108. eCollection 2023.ABSTRACTINTRODUCTION: In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IAg7) in register 3 (R3), creating a bimolecular IAg7/InsulinB:9-23 register 3 conformational epitope (InsB:R3). Previously, we showed that the InsB:R3-specific chimeric antigen receptor (CAR), constructed using an InsB:R3-monoclonal antibody, could guide CAR-expressing CD8 T cells to migrate to the islets and pancreatic lymph nodes. Regulatory T cells (Tregs) specific...
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Nyerhovwo Obarorakpor Deep Patel Reni Boyarov Nansalmaa Amarsaikhan Joseph Ray Cepeda Doreen Eastes Sylvia Robertson Travis Johnson Kai Yang Qizhi Tang Li Zhang Source Type: research

Gene expression profile of hiPSC-derived cells differentiated with growth factors, forskolin and conditioned medium from human adrenocortical cell line
CONCLUSIONS: The results of the study indicate that we obtained progenitors derived from endoderm with some characteristics of pancreatic-like cells. The endodermal derivative differentiation is a very challenging and complicated process; thus, the results presented in this study deserve closer consideration.PMID:37540158 | DOI:10.17219/acem/168603
Source: Adv Data - August 4, 2023 Category: Epidemiology Authors: Ewelina Stelcer Karol Jopek Ma łgorzata Blatkiewicz Anna Olechnowicz Kacper Kami ński Marta Szyszka Wiktoria Maria Suchorska Marcin Ruci ński Source Type: research