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Cancer: Neuroblastoma
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Total 288 results found since Jan 2013.
BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway
CONCLUSION: As a prognostic indicator of survival in NB patients, BCL11A might serve as a potential therapeutic target. BCL11A played a regulatory role in cell proliferation, invasion and migration in NB,which may be through the PI3K/AKT signaling pathway and induce EMT.PMID:35909289 | DOI:10.2174/1568009622666220728123748
Source: Current Cancer Drug Targets - August 1, 2022 Category: Cancer & Oncology Authors: Qianya Jin Yanmin Chen Shibei Du Dongqing Xu Juanqing Yue Lei Cai Xiaojun Yuan Source Type: research
11,12-Diacetyl-carnosol Protects SH-SY5Y Cells from Hydrogen Peroxide Damage through the Nrf2/HO-1 Pathway
CONCLUSION: These results demonstrate that NO.20 protects SH-SY5Y cells from H2O2-induced neurotoxicity by activating the Nrf2/HO-1 pathway. Thus, the neuroprotective and antioxidative stress effects of NO.20 may make it a promising neuroprotective compound for AD treatment.PMID:35620405 | PMC:PMC9129961 | DOI:10.1155/2022/4376812
Source: Evidence-based Complementary and Alternative Medicine - May 27, 2022 Category: Complementary Medicine Authors: Qingyi Luo Weiyan Hu Haofei Yu Rongping Zhang Xinglong Chen Source Type: research
Human Guanylate-Binding Protein 1 Positively Regulates Japanese Encephalitis Virus Replication in an Interferon Gamma Primed Environment
RNA virus infection triggers interferon (IFN) receptor signaling, leading to the activation of hundreds of interferon-stimulated genes (ISGs). Guanylate-binding proteins (GBPs) belong to one such IFN inducible subfamily of guanosine triphosphatases (GTPases) that have been reported to exert broad anti-microbial activity and regulate host defenses against several intracellular pathogens. Here, we investigated the role of human GBP1 (hGBP1) in Japanese encephalitis virus (JEV) infection of HeLa cells in both an IFNγ unprimed and primed environment. We observed enhanced expression of GBP1 both at transcript and protein level...
Source: Frontiers in cellular and infection microbiology - May 19, 2022 Category: Microbiology Source Type: research
Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling
Phytother Res. 2022 May 18. doi: 10.1002/ptr.7481. Online ahead of print.ABSTRACTPsoralidin (PSO) is a natural phenolic coumarin extracted from the seeds of Psoralea corylifolia L. Growing preclinical evidence indicates that PSO has anti-inflammatory, anti-vitiligo, anti-bacterial, and anti-viral effects. Growth arrest-specific gene 6 (GAS6) and its receptor, Axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. Notably, the neuroprotective role of the GAS6/Axl axis has been identified in previous studies. We hypothesize that PSO ameliorates cerebral hypoxia/reoxygenation ...
Source: Cell Research - May 18, 2022 Category: Cytology Authors: Wangrui Lei Songdi Wu Aizhen Zhao Zhen Wu Baoping Ding Wenwen Yang Chenxi Lu Xue Wu Xiyang Li Shaofei Zhang Ye Tian Yang Yang Source Type: research
eEF1A2 knockdown impairs neuronal proliferation and inhibits neurite outgrowth of differentiating neurons
Conclusions
Our results suggest that eEF1A2 may be required for neuronal proliferation and differentiation of SH-SY5Y cells. Increased cell death susceptibility against MPP+ in eEF1A2-knockdown neurons may imply the neuroprotective role of eEF1A2.
Source: NeuroReport - May 1, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway
Neurotoxicology. 2022 Apr 23:S0161-813X(22)00056-0. doi: 10.1016/j.neuro.2022.04.008. Online ahead of print.ABSTRACTProlonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival in different conditions. However, the role and mechanism of autophagy in sevoflurane-induced neurotoxicity were not fully elucidated. We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. Sevoflurane treatment significantly decrea...
Source: Neurotoxicology - April 26, 2022 Category: Neurology Authors: Jingjing Lv Hao Cheng Weidong Yao Can Liu Yongquan Chen Xiaoju Jin Zeyong Yang Yuanhai Li Source Type: research
