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Anti-Warburg effect via generation of ROS and inhibition of PKM2/ β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
Phytother Res. 2023 May 26. doi: 10.1002/ptr.7903. Online ahead of print.ABSTRACTTo elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells. MTT assay for cytotoxicity, RNA interference, cell cycle analysis for sub G1 population, nuclear and cytoplasmic extraction, lactate, Glucose and ATP assay by ELISA, Measurement of reactive oxygen species (ROS) generation, Western blotting, and immunoprecipitation assay were conducted in DU145 and PC3 prosta...
Source: Cell Research - May 26, 2023 Category: Cytology Authors: Ji-Na Pak Hyo-Jung Lee Deok Yong Sim Ji Eon Park Chi-Hoon Ahn Su-Yeon Park Jae-Ho Khil Bumsang Shim Bonglee Kim Sung-Hoon Kim Source Type: research

7,8-Diacetoxy-3-(4-methylsulfonylphenyl)-4-phenylcoumarin Induces ROS-dependent Cell Death in the A549 Human Lung Cancer Cell Line
CONCLUSION: The presence of 3-4-methylsulfonyl and 7,8-diacetoxy groups on 3,4-Diarylcoumarin is critical in modulating higher cytotoxic activity and could serve as a valuable template for the development of novel synthetic compounds as potential anticancer agents for lung cancer treatment.PMID:36854537 | DOI:10.21873/anticanres.16244
Source: Cell Research - February 28, 2023 Category: Cytology Authors: Musiliyu A Musa Qudus Kolawole Source Type: research

Novel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents
J Inorg Biochem. 2022 Sep 19;237:112005. doi: 10.1016/j.jinorgbio.2022.112005. Online ahead of print.ABSTRACTFor the first time, we herein report on the syntheses of two new Ru(II)/bipyridine/phenanthroline complexes containing lapachol as ligand: complex (1), [Ru (bipy)2(Lap)]PF6 and complex (2), [Ru(Lap)(phen)2]PF6, where bipy = 2,2'-bipyridine and ph en = 1,10-phenanthroline; Lap = lapachol (2-hydroxy-3-(3-methylbut-2-en-1- yl)naphthalene-1,4-dione). The complexes were synthesized and characterized by elemental analyses, molar conductivity, mass spectrometry, ultraviolet-visible and infrared spectroscopies, nuclear magn...
Source: Journal of Inorganic Biochemistry - September 26, 2022 Category: Biochemistry Authors: Rone Aparecido De Grandis Analu Rocha Costa Carlos Andr é Ferreira Moraes Nat ália Zaneti Sampaio Igor Henrique Cerqueira Wellington Garcia Marques Adriana Pereira Mundin Guedes Jo ão Honorato de Araujo-Neto Fernando Rog ério Pavan Felipe Cerqueira De Source Type: research

The toxicity mechanism of glabridin in prostate cancer cells is involved in reactive oxygen species-dependent PI3K/Akt pathway: Integrated utilization of bioinformatic analysis and in vitro test validation
Environ Toxicol. 2022 Aug 27. doi: 10.1002/tox.23649. Online ahead of print.ABSTRACTGlabridin is a prenylated isoflavonoid with considerable anticancer property. Reactive oxygen species (ROS) have evolved as regulators of many cellular signaling pathways in prostate cancer (PC). However, the role of ROS signaling in the anticancer activity of glabridin has not been investigated. Here, we attempted to evaluate the effect of glabridin on PC and the involvement of ROS signaling. Intracellular ROS and mitochondrial ROS (mitoROS) production in PC cell lines, DU-145 and LNCaP, were measured by H2DCFDA and MitoSOX Red staining, r...
Source: Cancer Control - August 27, 2022 Category: Cancer & Oncology Authors: Fengyan Zhang Fufang Wang Wenjie Li Liping Liang Xicheng Sang Source Type: research

Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF- β-independent, endoplasmic reticulum stress induced pathway
In this study, we aimed to elucidate the role of chronic cadmium (Cd) exposure in epithelial-mesenchymal transition (EMT) and thus malignant phenotypic changes of prostate cancer cells. Prostate cancer cells (PC-3 and DU145) were exposed to a non-toxic level (0.5 or 2 μM) of Cd for up to 3 months, which resulted in significantly promoted migration and invasion of the cells. These phenotypic changes were considered to be the consequence of enhanced EMT as evidenced by diminished expression of E-cadherin and increased vimentin expression. Regarding the mechanisms of Cd-induced EMT, we found Smad3 was activated but without u...
Source: Toxicology Letters - October 23, 2021 Category: Toxicology Authors: Weirong Hu Mizhen Xia Cheng Zhang Bingdong Song Zhengmei Xia Chunyu Guo Yingying Cui Weiying Jiang Shicheng Zhang Dexiang Xu Jun Fang Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration
BMB Rep. 2021 Jan 7:5184. Online ahead of print.ABSTRACTVoltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the hi...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Hyun Woo Park Min Seok Song Hun Ju Sim Pan Dong Ryu So Yeong Lee Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration.
Abstract Voltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the highly expressed Kv2.1 could detect reac...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Park HW, Song MS, Sim HJ, Ryu PD, Lee SY Tags: BMB Rep Source Type: research

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