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Cancer: Lung Cancer
Therapy: Chemotherapy
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Total 4426 results found since Jan 2013.
ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
CONCLUSIONS: ATM mutations define a distinct subset of NSCLC associated with KRAS mutations, increased TMB, decreased TP53 and EGFR co-occurrence, and potential increased sensitivity to ICIs in the context of DNA-damaging chemotherapy.PMID:37733794 | DOI:10.1158/1078-0432.CCR-23-1122
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Natalie I Vokes Ana Galan Cobo Margarita Fernandez-Chas David Molkentine Santiago Trevi ño Vitaly Druker Yu Qian Sonia Patel Stephanie Schmidt Lingzhi Hong Jeff Lewis Waree Rinsurongkawong Vadeerat Rinsurongkawong J Jack Lee Marcelo V Negrao Don L Gibbon Source Type: research
Clinical outcomes of ramucirumab plus docetaxel in the treatment of patients with non-small cell lung cancer after immunotherapy: a systematic literature review
CONCLUSIONS: Cumulatively, these results support the combination of ramucirumab plus docetaxel as an effective and safe subsequent therapy for the treatment of patients with metastatic NSCLC with disease progression irrespective of previous ICI treatment.PMID:37731641 | PMC:PMC10507469 | DOI:10.3389/fonc.2023.1247879
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Edward B Garon Carla Visseren-Grul Maria Teresa Rizzo Tarun Puri Suresh Chenji Martin Reck Source Type: research
Effectiveness and safety of Shenqi Fuzheng injection combined with platinum-based chemotherapy for treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis
CONCLUSION: SFI combined with PBC for the treatment of advanced NSCLC improved the ORR, DCR, and quality of life, and reduced the incidence of myelosuppression and gastrointestinal adverse reactions. However, considering the limitations of existing evidence, further verification using high-quality RCTs is required.SYSTEMATIC REVIEW REGISTRATION: https://inplasy.com/inplasy-2022-7-0026, identifier INPLASY202270026.PMID:37731634 | PMC:PMC10507621 | DOI:10.3389/fonc.2023.1198768
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Chenxi Qiao Shuaihang Hu Dandan Wang Kangdi Cao Zhuo Wang Xinyan Wang Xiumei Ma Zheng Li Wei Hou Source Type: research
A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer
CONCLUSIONS: Although the preventive effect of lafutidine on CIPN could not be demonstrated statistically, lafutidine FACT/GOG-Ntx scores showed a trend toward decreased neurotoxicity as chemotherapy proceeded. More reliable studies using lafutidine on the prevention of CIPN should be conducted.TRIAL REGISTRATION: Japan Registry of Clinical Trials identifier: jRCTs021200031.PMID:37731302 | DOI:10.21037/apm-23-90
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Katsuya Cho Hirotaka Saikawa Tatsuya Hashimoto Hiroshi Katagiri Yoshihiro Owada Kazuhiro Yakuwa Itaru Fujimura Yu Utsumi Masachika Akiyama Hiromi Nagashima Fumiaki Takahashi Makoto Maemondo Source Type: research
ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
CONCLUSIONS: ATM mutations define a distinct subset of NSCLC associated with KRAS mutations, increased TMB, decreased TP53 and EGFR co-occurrence, and potential increased sensitivity to ICIs in the context of DNA-damaging chemotherapy.PMID:37733794 | DOI:10.1158/1078-0432.CCR-23-1122
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Natalie I Vokes Ana Galan Cobo Margarita Fernandez-Chas David Molkentine Santiago Trevi ño Vitaly Druker Yu Qian Sonia Patel Stephanie Schmidt Lingzhi Hong Jeff Lewis Waree Rinsurongkawong Vadeerat Rinsurongkawong J Jack Lee Marcelo V Negrao Don L Gibbon Source Type: research
Long non-coding RNAs in non-small cell lung cancer: Implications for preventing therapeutic resistance
Biochim Biophys Acta Rev Cancer. 2023 Sep 19:188982. doi: 10.1016/j.bbcan.2023.188982. Online ahead of print.ABSTRACTLung cancer has the highest mortality and morbidity rates among all cancers worldwide. Despite many complex treatment options, including radiotherapy, chemotherapy, targeted drugs, immunotherapy, and combinations of these treatments, efficacy is low in cases of resistance to therapy, metastasis, and advanced disease, contributing to low overall survival. There is a pressing need for the discovery of novel biomarkers and therapeutic targets for the early diagnosis of lung cancer and to determine the efficacy ...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Wenjuan Liu Bingli Zuo Wenting Liu Yanfei Huo Nasha Zhang Ming Yang Source Type: research
Subtype of SCLC Is an Intrinsic and Persistent Feature Through Systemic Treatment
CONCLUSIONS: Subtype of SCLC generally remains the same after acquiring chemotherapy resistance. Plasticity was observed with rare cases switching from NEUROD1-predominant to ASC1-predominant SCLC. Resubtyping is unnecessary for the consideration of novel subtype-specific targeted agents, except cases with NEUROD1-predominant subtype.PMID:37731627 | PMC:PMC10507151 | DOI:10.1016/j.jtocrr.2023.100561
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Ying-Chun Lo Joel Rivera-Concepcion George Vasmatzis Marie-Christine Aubry Konstantinos Leventakos Source Type: research
Left epigastric isolated tumor fed by the inferior phrenic artery diagnosed as ectopic hepatocellular carcinoma: A case report
CONCLUSION: This asymptomatic ectopic HCC case described achieved an excellent result due to early detection, radical resection, and systematic surveillance.PMID:37731571 | PMC:PMC10507550 | DOI:10.12998/wjcc.v11.i26.6231
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hong-Bo Liu Li-Hua Zhao Yong-Jian Zhang Zhi-Feng Li Lei Li Qian-Peng Huang Source Type: research
Subtype of SCLC Is an Intrinsic and Persistent Feature Through Systemic Treatment
CONCLUSIONS: Subtype of SCLC generally remains the same after acquiring chemotherapy resistance. Plasticity was observed with rare cases switching from NEUROD1-predominant to ASC1-predominant SCLC. Resubtyping is unnecessary for the consideration of novel subtype-specific targeted agents, except cases with NEUROD1-predominant subtype.PMID:37731627 | PMC:PMC10507151 | DOI:10.1016/j.jtocrr.2023.100561
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Ying-Chun Lo Joel Rivera-Concepcion George Vasmatzis Marie-Christine Aubry Konstantinos Leventakos Source Type: research
Left epigastric isolated tumor fed by the inferior phrenic artery diagnosed as ectopic hepatocellular carcinoma: A case report
CONCLUSION: This asymptomatic ectopic HCC case described achieved an excellent result due to early detection, radical resection, and systematic surveillance.PMID:37731571 | PMC:PMC10507550 | DOI:10.12998/wjcc.v11.i26.6231
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hong-Bo Liu Li-Hua Zhao Yong-Jian Zhang Zhi-Feng Li Lei Li Qian-Peng Huang Source Type: research
ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
CONCLUSIONS: ATM mutations define a distinct subset of NSCLC associated with KRAS mutations, increased TMB, decreased TP53 and EGFR co-occurrence, and potential increased sensitivity to ICIs in the context of DNA-damaging chemotherapy.PMID:37733794 | DOI:10.1158/1078-0432.CCR-23-1122
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Natalie I Vokes Ana Galan Cobo Margarita Fernandez-Chas David Molkentine Santiago Trevi ño Vitaly Druker Yu Qian Sonia Patel Stephanie Schmidt Lingzhi Hong Jeff Lewis Waree Rinsurongkawong Vadeerat Rinsurongkawong J Jack Lee Marcelo V Negrao Don L Gibbon Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Technology in Cancer Research and Treatment - September 20, 2023 Category: Cancer & Oncology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
The inherited KRAS-variant as a biomarker of Cetuximab Response in NSCLC
CONCLUSIONS/DISCUSSION: Although an overall survival advantage was not achieved in KRAS-variant patients, there is potential impact of cetuximab for this genetic subset of patients. In contrast, cetuximab seems to harm non-variant patients. These findings further support the importance of genetic patient selection in trials studying the addition of systemic agents to radiotherapy.PMID:37728512 | DOI:10.1158/2767-9764.CRC-23-0084
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Joanne B Weidhaas Chen Hu Ritsuko Komaki Gregory A Masters George R Blumenschein Joe Y Chang Bo Lu Adam P Dicker Jeffrey A Bogart Yolanda I Garces Samir Narayan Clifford G Robinson Vivek S Kavadi Joel S Greenberger Christopher D Koprowski James W Welsh El Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
