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Cancer: Lung Cancer
Drug: Acetylcysteine
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Total 55 results found since Jan 2013.
Antioxidants stimulate BACH1-dependent tumor angiogenesis
J Clin Invest. 2023 Aug 31:e169671. doi: 10.1172/JCI169671. Online ahead of print.ABSTRACTLung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs); but growing evidence indicate that transcriptional programs beyond HIFs control tumor angiogenesis. Here we show that the redox-sensitive transcription factor BTB and CNC homology 1 (BACH1) controls the transcription of a broad range of angiogenesis genes. BACH1 is stabilized by lowering reactive oxygen species levels; consequently, angiogenesis gene expression in lung cancer cells, tu...
Source: Clinical Lung Cancer - August 31, 2023 Category: Cancer & Oncology Authors: Ting Wang Yongqiang Dong Zhiqiang Huang Guoqing Zhang Ying Zhao Haidong Yao Jianjiang Hu Elin T üksammel Huan Cai Ning Liang Xiufeng Xu Xijie Yang Sarah Schmidt Xi Qiao Susanne Schlisio Staffan Str ömblad Hong Qian Changtao Jiang Eckardt Treuter Martin Source Type: research
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
Eur J Pharmacol. 2023 Aug 23:176004. doi: 10.1016/j.ejphar.2023.176004. Online ahead of print.ABSTRACTSmall molecule drugs are of significant importance in the treatment of non-small cell lung cancer (NSCLC). Here, we explored biological effects of the PI3K/mTOR inhibitor VS-5584 on NSCLC. Our findings indicated that VS-5584 administration resulted in a dose-dependent inhibition of NSCLC cell proliferation, as well as the induction of apoptosis and cycle arrest. Additionally, we observed a significant increase in intracellular reactive oxygen species (ROS) levels following VS-5584 treatment. The use of the ROS inhibitor N-...
Source: European Journal of Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Senxia Zhao Yibin Li Gang Li Juanping Ye Rong Wang Xiaoting Zhang Fei Li Chang Gao Junbiao Li Jie Jiang Yanjun Mi Source Type: research
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS < sup > E < /sup >
Xenobiotica. 2023 Jun 19:1-29. doi: 10.1080/00498254.2023.2227976. Online ahead of print.ABSTRACT1. Compound Kushen injection (CKI) is a kind of sterilized water-soluble traditional Chinese medicine preparation that has been used for the clinical treatment of a variety of cancers (hepatocellular carcinoma, lung cancer, etc.) for nineteen years. However, to date, the metabolism-related study on CKI in vivo has not been conducted.2. An integrated analytical strategy was established to investigate the metabolic profile of alkaloids of CKI in rat plasma, urine and feces based on ultra-high performance liquid chromatography-ele...
Source: Xenobiotica - June 19, 2023 Category: Research Authors: Li Zhang Ruijuan Li Ting Zheng Huan Wu Yanyan Yin Source Type: research
Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation
In this study, we found for the first time that Cinchonine (Cin) can act as an autophagy suppressor and exert anti-tumor effects. Cin significantly inhibited the proliferation, migration, and invasion of cancer cells in vitro and the tumor growth and metastasis in vivo, without obvious toxic effects. We found that Cin suppressed the autophagic process by blocking autophagosome degradation through the inhibition of the maturation of lysosomal hydrolases. Cin-mediated autophagy inhibition resulted in the elevated ROS level and the accumulation of damaged mitochondria, which in turn promoted apoptosis. N-acetylcysteine, a pot...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2023 Category: Drugs & Pharmacology Authors: Huan Wang Yuting Shi Dannv Ma Mengqing Cao Yuchao Sun Xinyuan Jiang Zhiyong Xu Yongfang Wang Ying Yang Yueli Shi Kai Wang Source Type: research
Bleomycin Overdose in a Patient with Stage II Hodgkin Lymphoma: A Case Report of a Medication Error
Br J Clin Pharmacol. 2023 Apr 14. doi: 10.1111/bcp.15744. Online ahead of print.ABSTRACTBleomycin is an antibiotic with cytotoxic properties that is commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in the dosage nomenclature of bleomycin appears universally, which increases the risk of medication errors. However, to the best of our knowledge, no such cases have been reported. Herein, we present a rare case report of a medication error caused by a bleomycin overdose. At the third cycle of chemotherapy, a 25-year-old patient with Stage II Hodgkin Lymphoma received a ten times hig...
Source: Clinical Lung Cancer - April 15, 2023 Category: Cancer & Oncology Authors: M D Zhang Jieting Xue Shuyi Chen Xiaolin M D Yang Hai Source Type: research
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer
This study focused on Nrf2-mediated antioxidant systems in RES-treated lung cancer cells. A549 and H1299 cells were treated with various concentrations of RES at different times. RES decreased cell viability, inhibited cell proliferation, and increased the number of senescent and apoptotic cells in a concentration- and time-dependent manner. Moreover, RES-induced lung cancer cell arrest at the G1 phase was accompanied by changes in apoptotic proteins (Bax, Bcl-2, and cleaved caspase 3). Furthermore, RES induced a senescent phenotype along with changes in senescence-related markers (senescence-associated β-galactosidase ac...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Chunhua Liang Kefan Yi Xu Zhou Xiaoting Li Caiyun Zhong Hui Cao Chunfeng Xie Jianyun Zhu Source Type: research
7,8-Diacetoxy-3-(4-methylsulfonylphenyl)-4-phenylcoumarin Induces ROS-dependent Cell Death in the A549 Human Lung Cancer Cell Line
CONCLUSION: The presence of 3-4-methylsulfonyl and 7,8-diacetoxy groups on 3,4-Diarylcoumarin is critical in modulating higher cytotoxic activity and could serve as a valuable template for the development of novel synthetic compounds as potential anticancer agents for lung cancer treatment.PMID:36854537 | DOI:10.21873/anticanres.16244
Source: Cell Research - February 28, 2023 Category: Cytology Authors: Musiliyu A Musa Qudus Kolawole Source Type: research
H3K27 acetylation activated-CCS regulates autophagy and apoptosis of lung cancer by alleviating oxidative stress
Tissue Cell. 2022 Oct 28;80:101964. doi: 10.1016/j.tice.2022.101964. Online ahead of print.ABSTRACTCopper chaperone for superoxide dismutase (CCS) is abnormally expressed in various human malignancies. However, the function and mechanism of CCS in lung cancer progression remain unclear. In the current study, CCS protein and mRNA levels were found to be increased in lung adenocarcinoma (LUAD) tissue and cell lines. Patients with higher CCS levels had a poorer prognosis. Decreasing the enrichment of histone H3 Lys27 acetylation (H3K27ac) by A-485 inhibited CCS expression. CCS depletion upregulated reactive oxygen species (RO...
Source: Tissue and Cell - November 19, 2022 Category: Cytology Authors: Yan Hu Hanshuo Mu Zhiping Deng Source Type: research
Pendulone induces apoptosis via the ROS-mediated ER-stress pathway in human non-small cell lung cancer cells
CONCLUSION: Our findings provide evidence that pendulone induces apoptosis by inducing ER stress through ROS accumulation and mitochondrial dysfunction in NSCLC cell lines.PMID:35288263 | DOI:10.1016/j.tiv.2022.105346
Source: Toxicology in Vitro - March 15, 2022 Category: Toxicology Authors: Wen-Chien Cheng Ya Wen Yen-Shuo Chiu Chia-Hao Chou Chen-Jen Lim Sheng-Hao Lin Jia-Ming Chang Chi-Chien Lin Source Type: research
