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Total 445 results found since Jan 2013.
Medico-economic impact of thoracoscopy versus thoracotomy in lung cancer: multicentre randomised controlled trial (Lungsco01)
CONCLUSIONS: Given our results, the economic efficiency of video-thoracoscopy at 30 days remains fragile at a willingness-to-pay threshold of €25,000/QALY. The economic efficiency is not established beyond that time horizon. The acceptability curves given will allow decision-makers to judge the probability of efficiency of this technology at other willingness-to-pay thresholds.TRIAL REGISTRATION: NCT02502318.PMID:37723516 | DOI:10.1186/s12913-023-09962-y
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Anne-Laure Soilly Ludwig Serge Aho Gl élé Alain Bernard Halim Abou Hanna Marc Filaire Pierre Magdaleinat Charles Marty-An é Fran çois Tronc Renaud Grima Jean-Marc Baste Pascal-Alexandre Thomas Bertrand Richard De Latour Arnaud Pforr Pierre-Beno ît Pa Source Type: research
Venous thrombotic events and impact on outcomes in patients treated with first-line single-agent pembrolizumab in PD-L1 ≥ 50% advanced non small cell lung cancer
CONCLUSION: The incidence of VTE appears to be as high with in first-line immunotherapy as with chemotherapy in patients with mNSCLC, with in patient with VTE, a no significant trend for lower PFS and OS in multivariate analysis. more marked impact on PFS than on OS.PMID:37626173 | DOI:10.1007/s00432-023-05321-w
Source: Clinical Lung Cancer - August 25, 2023 Category: Cancer & Oncology Authors: H élène Doubre Laurent Greillier Gr égoire Justeau Charles Ricordel Aur élie Swalduz Hubert Curcio Olivier Bylicki Jean-Bernard Auliac Florian Guisier Laurence Bigay-Game Marie Bernardi Julian Pinsolle Karim Amrane Chantal Decroisette Renaud Descourt Source Type: research
Is the number of ideal cardiovascular health metrics in midlife associated with lower risk of cancer? Evidence from 3 European prospective cohorts
CMAJ Open. 2023 Aug 22;11(4):E774-E781. doi: 10.9778/cmajo.20220175. Print 2023 Jul-Aug.ABSTRACTBACKGROUND: Primordial prevention may be a relevant strategy for the prevention of cancer. Given the commonality of risk factors and mechanisms between cancer and cardiovascular disease, we examined the associations between the number of ideal cardiovascular health metrics in midlife and incident cancer.METHODS: In 3 European cohorts (NutriNet-Santé and GAZEL, France; Whitehall II, United Kingdom), the number of ideal cardiovascular health metrics was determined at baseline (range 0-7). Follow-up for cancer events was until Oct...
Source: cmaj - August 22, 2023 Category: General Medicine Authors: Thomas T van Sloten Rachel E D Climie Omar Deraz Marie-C écile Périer Eugenie Valentin Aurore Fayosse S éverine Sabia Elisabete Weiderpass Xavier Jouven Marcel Goldberg Marie Zins Mathilde Touvier M élanie Deschasaux-Tanguy L éopold Fezeu Serge Hercb Source Type: research
Increasing transparency in indirect treatment comparisons: is selecting effect modifiers the missing part of the puzzle? A review of methodological approaches and critical considerations
J Comp Eff Res. 2023 Aug 21:e230046. doi: 10.57264/cer-2023-0046. Online ahead of print.ABSTRACTFailure to adjust for effect modifiers (EMs) in indirect treatment comparisons (ITCs) can produce biased and uncertain effect estimates. This is particularly important for health technology assessments (HTAs), where the availability of new treatments is based on comparative effectiveness results. Much emphasis has been placed on advancing ITC methods to adjust for EMs, yet whether EMs are appropriately identified for the conduct of ITCs in the first place is unclear. To understand the extent of guidance and requirements for the ...
Source: Journal of Comparative Effectiveness Research - August 21, 2023 Category: General Medicine Authors: Andreas Freitag Laura Gurskyte Grammati Sarri Source Type: research
In Silico Studies on Natural Products and Derivatives Against Different Types of Cancer
Curr Med Chem. 2023 Jun 14. doi: 10.2174/0929867330666230614153430. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), cancer is the second cause of death worldwide, responsible for almost 10 million deaths and accounting for one in every six deaths. It is a disease that can affect any organ or tissue with rapid progression to the final stage, which is metastasis, in which the disease spreads to different regions of the body. Many studies have been carried out to find a cure for cancer. Early diagnosis contributes to the individual achieving the cure; however, deaths are increasing considerably...
Source: Current Medicinal Chemistry - June 15, 2023 Category: Chemistry Authors: Alex France Messias Monteiro F ábia Martins da Silva Teresa Carolliny Moreira Lustoza Rodrigues Cl écio Sousa Ramos Marcus Tullius Scotti Luciana Scotti Source Type: research
