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Cancer: Lung Cancer
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Total 241 results found since Jan 2013.
TP53, ATM Comutation Might Help Guide Lung-Cancer Immunotherapy TP53, ATM Comutation Might Help Guide Lung-Cancer Immunotherapy
In patients with non-small-cell lung cancer (NSCLC), the presence of tumor protein p53 (TP53) and ataxia-telangiectasia mutated (ATM) comutation might indicate better response to immune-checkpoint inhibitors (ICIs), according to Chinese researchers.Reuters Health Information
Source: Medscape Allergy Headlines - October 3, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Bristol-Myers ' Immunotherapies Show Promise in Lung Cancer Trial Bristol-Myers ' Immunotherapies Show Promise in Lung Cancer Trial
Reuters Health Information
Source: Medscape Allergy Headlines - October 24, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Immunotherapy Appears Safe, Effective in Elderly With Lung Cancer Immunotherapy Appears Safe, Effective in Elderly With Lung Cancer
Immunotherapy appears to be safe and effective for treating non-small-cell lung cancer (NSCLC) in older people, researchers from Italy report.Reuters Health Information
Source: Medscape Allergy Headlines - October 30, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Vaping May Be Worse for Heart Health Than Tobacco Cigarettes, New Study Finds
E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference.
The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blun...
Source: TIME: Health - November 11, 2019 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized embargoed study heart health vaping Source Type: news
Patient satisfaction and perception of indwelling pleural catheters
Discussion: IPCs are successfully used in patients with malignant pleural effusions with good patient satisfaction. Therefore, consideration needs to be given as to whether an IPC should be offered as a primary intervention.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Messeder, S. J., Thomson, M., Currie, G., Chetty, M. Tags: Lung cancer Source Type: research
AstraZeneca ' s Imfinzi Gets Speedy FDA Review for Small Cell Lung Cancer AstraZeneca ' s Imfinzi Gets Speedy FDA Review for Small Cell Lung Cancer
British drugmaker AstraZeneca Plc said on Friday its immunotherapy cancer treatment Imfinzi (durvalumab) has been granted a speedy review by the U.S. medicines watchdog for the treatment of a particularly aggressive type of lung cancer.Reuters Health Information
Source: Medscape Allergy Headlines - December 10, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
The Role of Mast Cells in IgE-Independent Lung Diseases
AbstractMast cells (MCs) are granular cells of the innate immune system which develop from CD34+/CD117+ progenitors and play a role in orchestrating adaptive immune responses. They have a well-known role in allergic reactions following immunoglobulin (Ig)E-mediated activation of the cell-surface expressed IgE high-affinity receptor (Fc εRI). MCs can also respond to various other stimuli due to the expression of a variety of receptors including toll-like receptors (TLRs), immunoglobulin (IgG) receptors (FcγR), complement receptors such as C5a (CD88) expressed by skin MCs, neuropeptides receptors including nerve growth fac...
Source: Clinical Reviews in Allergy and Immunology - February 20, 2020 Category: Allergy & Immunology Source Type: research
The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases
Emerging findings indicate there is a vital cross-talk between gut microbiota and the lungs, which is known as gut–lung axis. The gut disturbances in lung diseases including allergy, asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer were observed by extensive studies. Investigating how gut microbiota impact other distant organs is of great interest in recent years. Although it has not been fully understood whether the disturbance is the cause or effect of lung diseases, alterations in the gut microbial species and metabolites have been linked to changes in immune responses and inflammation as...
Source: Frontiers in Microbiology - February 24, 2020 Category: Microbiology Source Type: research
New Tests Enter the Scene as COVID-19 Rages On
Tests for the coronavirus (COVID-19) continue to roll in as the U.S. faces a public health crisis. Thermo Fisher Scientific and Mayo Clinic are the latest with diagnostic contributions.
Waltham, MA-based Thermo Fisher is the second company to be granted an Emergency Use Authorization for a commercially developed COVID-19 test. MD+DI reported Roche received this designation late last week too for the cobas SARA-COV-2 test.
In a press release, Thermo Fisher said the authorized test uses Applied Biosystems TaqPath Assay technology and is designed to provide patient results within four hours of a sample being received by a lab...
Source: MDDI - March 16, 2020 Category: Medical Devices Authors: Omar Ford Tags: IVD Regulatory and Compliance Source Type: news
Onc Daily: ' Staging the Aging, ' Immuno-Combo for Lung Cancer Onc Daily: ' Staging the Aging, ' Immuno-Combo for Lung Cancer
These are the most important oncology stories you need to know about today.Medscape Medical News
Source: Medscape Allergy Headlines - May 18, 2020 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Air pollution, racial disparities, and COVID-19 mortality
Since late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people worldwide and resulted in more than 200,000 coronavirus disease 2019 (COVID-19) deaths. Emerging data suggest that elderly people as well as individuals with underlying health conditions are at a higher risk of hospitalization and death.1-3 Interestingly, the Centers for Disease Control and Prevention ’s list of risk factors for severe COVID-19 (Fig 1) largely overlap with the list of diseases that are known to be worsened by chronic exposure to air pollution, including diabetes, heart diseases, and chronic airwa...
Source: Journal of Allergy and Clinical Immunology - May 6, 2020 Category: Allergy & Immunology Authors: Eric B. Brandt, Andrew F. Beck, Tesfaye B. Mersha Tags: Editorial Source Type: research
Multisystem Inflammation and Susceptibility to Viral infections in Human ZNFX1 Deficiency
CONCLUSION: ZNFX1 is an important regulator of the response to double-stranded nucleic acids stimuli following viral infections. ZNFX1 deficiency predisposes to severe viral infections and a multisystem inflammatory disease.PMID:33872655 | DOI:10.1016/j.jaci.2021.03.045
Source: Clinical Lung Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Stefano Vavassori Janet Chou Laura Eva Faletti Veronika Haunerdinger Lennart Opitz Pascal Joset Christopher J Fraser Seraina Prader Xianfei Gao Luise A Schuch Matias Wagner Julia Hoefele Maria Elena Maccari Ying Zhu George Elakis Michael T Gabbett Maria F Source Type: research
International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome
CONCLUSIONS: Graft failure, graft instability and poor graft function requiring unplanned donor cell infusion were major barriers to successful HCT. Post-HCT mTORi use may confer an advantage to residual host cells, promoting graft instability. Longer term post-HCT follow-up of more patients is needed to elucidate the kinetics of immune reconstitution and donor chimerism, establish approaches that reduce graft instability, and assess the completeness of phenotype reversal over time.PMID:34033842 | DOI:10.1016/j.jaci.2021.04.036
Source: Clinical Lung Cancer - May 25, 2021 Category: Cancer & Oncology Authors: Dimana Dimitrova Zohreh Nademi Maria Elena Maccari Stephan Ehl Gulbu Uzel Takahiro Tomoda Tsubasa Okano Kohsuke Imai Benjamin Carpenter Winnie Ip Kanchan Rao Austen J J Worth Alexandra Laberko Anna Mukhina B énédicte Néven Despina Moshous Carsten Speck Source Type: research
Bromodomain and extraterminal (BET) protein inhibition of IgG/IgE production in murine B cells is counter-balanced by a strong Th2 bias
CONCLUSION: Altogether, BET inhibition thus interweaves intrinsic negative effects on B cells with a parallel complex reshaping of T-cell polarisation which can increase type 2 cytokines and eventually promote B-cell-dependent immunopathology. These opposite and potentially hazardous immunomodulatory effects raise concerns for clinical use of BET inhibitors in patients with immune disorders.PMID:34136216 | PMC:PMC8164936 | DOI:10.1002/cti2.1280
Source: Clinical Lung Cancer - June 17, 2021 Category: Cancer & Oncology Authors: Zeinab Dalloul Marie Best Pauline Chenuet Iman Dalloul Sandrine Le Noir Dieudonn ée Togbé Myl ène Gador Bernhard Ryffel Valerie Fj Quesniaux Yolla El Makhour Fran çois Boyer Jean-Claude Aldigier Jeanne Cook-Moreau Nicolas Fazilleau Michel Cogn é Source Type: research
