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Screening for Pancreatic Adenocarcinoma Using Signals From Web Search Logs: Feasibility Study and Results.
CONCLUSION: Signals in search logs show the possibilities of predicting a forthcoming diagnosis of pancreatic adenocarcinoma from combinations of subtle temporal signals revealed in the queries of searchers. PMID: 27271506 [PubMed - as supplied by publisher]
Source: JOP - June 6, 2016 Category: Gastroenterology Authors: Paparrizos J, White RW, Horvitz E Tags: J Oncol Pract Source Type: research

Screening for Pancreatic Adenocarcinoma Using Signals From Web Search Logs: Feasibility Study and Results FOCUS ON QUALITY
Conclusion: Signals in search logs show the possibilities of predicting a forthcoming diagnosis of pancreatic adenocarcinoma from combinations of subtle temporal signals revealed in the queries of searchers.
Source: Journal of Oncology Practice - August 9, 2016 Category: Cancer & Oncology Authors: Paparrizos, J., White, R. W., Horvitz, E. Tags: Information systems, Epidemiology, Diagnosis & Staging FOCUS ON QUALITY Source Type: research

The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
Conclusions: This meta-analysis demonstrated that CD44 overexpression might be an unfavorable prognostic factor for CRC patients and could be used to predict poor differentiation, lymph node metastasis and distant metastasis. Introduction Although therapies for colorectal cancer (CRC) has improved in recent years, colorectal cancer is still the third most common cause of cancer related death worldwide (1). Metastasis are observed in 25% of patients at initial diagnosis and approximately 50% of patients will develop metastasis (2). Presently, the outcome prediction and the therapy schedule determination of CRC patie...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Systematic Search for Present and Potential Portals of Entry for Infective Endocarditis
ConclusionsOur search for the POEs of present IEs was often successful, as was searching for an oral or dental or a gastrointestinal POE of a new IE episode. We advise the systematic performance of stomatologic examinations in patients with IE and performance of colonoscopy in patients ≥50 years of age or at high risk for colorectal cancer.
Source: Journal of the American College of Cardiology - January 12, 2016 Category: Cardiology Source Type: research

Laparoscopic versus open distal pancreatectomy for pancreatic cancer.
CONCLUSIONS: Currently, no randomised controlled trials have compared laparoscopic distal pancreatectomy versus open distal pancreatectomy for patients with pancreatic cancers. In observational studies, laparoscopic distal pancreatectomy has been associated with shorter hospital stay as compared with open distal pancreatectomy. Currently, no information is available to determine a causal association in the differences between laparoscopic versus open distal pancreatectomy. Observed differences may be a result of confounding due to laparoscopic operation on less extensive cancer and open surgery on more extensive cancer. In...
Source: Cochrane Database of Systematic Reviews - April 3, 2016 Category: Journals (General) Authors: Riviere D, Gurusamy KS, Kooby DA, Vollmer CM, Besselink MG, Davidson BR, van Laarhoven CJ Tags: Cochrane Database Syst Rev Source Type: research

Cellular mesenchymal epithelial transition (C-MET) gene copy number variation in gastric adenocarcinoma: A pilot search for new marker for targeted therapy in HER-2/neu resistance.
Abstract Increasing HER-2/neu resistance in gastric carcinoma has encouraged search for new biomarkers for targeted therapy. Cellular mesenchymal epithelial transition (C-MET) is one such tyrosine kinase inhibitor proposed for personalized salvage treatment. We determined frequency of C-MET gene copy number variation (CNV) by Fluorescent in-situ hybridization (FISH) in gastric adenocarcinoma (GAC) and sought its correlation with conventional clinicopathologic parameters. Dual-coloured FISH was done on 32 GAC cases. C-MET gene and centromere 7 signals were counted under fluorescent microscope and ratio was calculat...
Source: Indian Journal of Pathology and Microbiology - December 31, 2019 Category: Pathology Authors: Jain P, Wadhwa N, Joshi MK, Jain M, Halder A, Mishra K Tags: Indian J Pathol Microbiol Source Type: research

Novel approaches in search for biomarkers of cholangiocarcinoma
World J Gastroenterol. 2022 Apr 21;28(15):1508-1525. doi: 10.3748/wjg.v28.i15.1508.ABSTRACTCholangiocarcinoma (CCA) arises from the ductular epithelium of the biliary tree, either within the liver (intrahepatic CCA) or more commonly from the extrahepatic bile ducts (extrahepatic CCA). This disease has a poor prognosis and a growing worldwide prevalence. The poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging, especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA, or distal CCA and pancreatic head adenocarcinoma. Most patients present with an a...
Source: World Journal of Gastroenterology : WJG - May 18, 2022 Category: Gastroenterology Authors: Lavinia-Patricia Mocan Maria Ilie ș Carmen Stanca Melincovici Mihaela Sp ârchez Rare ș Crăciun Iuliana Nenu Adelina Horhat Cristian Tefas Zeno Sp ârchez Cristina Adela Iuga Tudor Mocan Carmen Mihaela Mihu Source Type: research