The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
Conclusions: This meta-analysis demonstrated that CD44 overexpression might be an unfavorable prognostic factor for CRC patients and could be used to predict poor differentiation, lymph node metastasis and distant metastasis. Introduction Although therapies for colorectal cancer (CRC) has improved in recent years, colorectal cancer is still the third most common cause of cancer related death worldwide (1). Metastasis are observed in 25% of patients at initial diagnosis and approximately 50% of patients will develop metastasis (2). Presently, the outcome prediction and the therapy schedule determination of CRC patients is based on the TNM classification (3). However, TNM classification cannot precisely predict the prognosis of CRC patients at an early stage, therefore, finding the bio-markers in CRC patients is very important for diagnosis and prognosis prediction. Currently, accumulating evidence supports a hypothesis that a subpopulation of cancer cells, called cancer stem cells (CSCs) exist, which contribute to tumor initiation, recurrence and resistance to radio-or chemotherapy (4–7). Although CSCs play crucial roles in cancer initiation and progression, there is no normalized CSCs marker. It has recently been reported that CSCs markers, such as CD133, CD44, EpCAM, and ALDH1, are potential prognostic markers for various cancers (7–9). Among them, CD44 is the most common reported CSCs marker in CRC (8, 9). CD44 is an important membrane receptor for hya...
Authors: Pennisi PA, Fernández MC, Martin A Abstract Pheochromocytomas/paragangliomas (PCCs/PGLs) are rare neuroendocrine tumors, developed from chromaffin cells derived from the neural crest. From a genetic point of view PCCs/PGLs are divided as sporadic cases, and inherited cases as part of hereditary (familial) syndromes. While the majority is benign, up to 26% of PCCs/PGLs will undergo malignant transformation. Validated prognostic pathological parameters for malignant PCCs/PGLs are still lacking. Signaling that follows the interactions between IGFs and their receptor/s in tumor cells received extensive ...
Authors: Turkkahraman D, Karatas Torun N, Randa NC Abstract Loss-of-function mutations in immunoglobulin superfamily, member 1 (IGSF1) gene cause X-linked central hypothyroidism, and therefore its mutation affects mainly males. Central hypothyroidism in males is the hallmark of the disorder, however some patients additionally present with hypoprolactinemia, transient and partial growth hormone deficiency, early/normal timing of testicular enlargement but delayed testosterone rise in puberty, and adult macroorchidism. Here, we report a boy with congenital central hypothyroidism caused by a novel variant in IGSF1 gen...
The European Society for Dermatological Research (ESDR) has been my home in skin research since the mid-1980s when I started training as a dermatology resident and physician scientist in Z ürich, Switzerland. After active research contributions to the annual meetings for many years, I became a member of the ESDR board and then Secretary Treasurer from 1999 to 2001, followed by the ESDR presidency in 2002. Characteristic for my time in the ESDR leadership was pursuit of scientific exc ellence at the meetings, international growth, and intersociety collaboration.
On behalf of all the Japanese Society for Investigative Dermatology (JSID) members, we would like to congratulate the European Society for Dermatological Research (ESDR) on its 50th anniversary! It must have been a long and winding road to achieve the current big success of ESDR, which always provides a harmonious and welcoming atmosphere to people attending its meetings from around the world. Although each country in European communities has a different background, ESDR unites people with the same aim to advance investigative dermatology and cutaneous biology.
When I started my clinical training in dermatology in 1981 and got involved in basic research in 1984, in those days for young German-speaking dermatology researchers, there was one important scientific meeting, the meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF, Association of Dermatological Research). Presenting an abstract at this meeting was a must, and having been selected for oral presentation was an extraordinary achievement. There was another extremely important forum, the meeting of the Society of Investigative Dermatology (SID).
Having been involved in the European Society for Dermatological Research (ESDR) from the 1980s, we have had the opportunity to observe the spectacular development of our society from early small meetings in the Netherlands to major international meetings held in many European centers. Our first ESDR meetings were notable because of the stimulating and friendly atmosphere with full sharing of ideas and new discoveries, even prepublication. Such an atmosphere has been preserved over time and has generated many research partnerships, including our own collaboration in keratinocyte (KC) biology and genetic skin diseases.
To better understand and interpret the trends in cutaneous research, we carried out a network analysis of all the titles of the submitted abstracts of the annual meetings of the European Society of Dermatological Research (ESDR), including the International Investigative Dermatology (IID) meetings between 2010 and 2019. Network analysis is a data science tool to process, analyze, and visualize big sets of data. As expected, psoriasis was the frontrunner in each of the annual meetings, followed by dermatitis and melanoma.
Publication date: Available online 12 August 2020Source: Journal of Oral Biology and Craniofacial ResearchAuthor(s): Alekhya Kanaparthi, Divya Dukkireddy, Hema Gopalaiah, Kesary Satya Prakash Reddy, Tejaswi Katne, Ramlal Gantala
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