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Total 121 results found since Jan 2013.

Gas Embolic Stroke Secondary to Bowel Infarction
A 69-year-old gentleman with metastatic esophageal adenocarcinoma presented with acute abdominal pain to the emergency medicine department and subsequently developed an acute left hemiplegia while in the resuscitation unit. An unenhanced computed tomography (CT) scan of the head showed right frontal cerebral gas emboli while an unenhanced CT scan of the abdomen and pelvis showed extensive portal venous gas and pneumatosis intestinalis, presumed secondary to bowel infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - November 16, 2015 Category: Neurology Authors: Dhruv Parikh, Joe Joseph Leyon, Swarupsinh Chavda Tags: Case Studies Source Type: research

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke
Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases. Particularly in ischemic stroke (IS), the abnormal expression of MALAT1 played important roles includi...
Source: Lipids in Health and Disease - April 1, 2020 Category: Lipidology Authors: Yan Wang, Xi-Xi Gu, Hua-Tuo Huang, Chun-Hong Liu and Ye-Sheng Wei Tags: Research Source Type: research

Concomitant AngioVac thrombectomy and patent foramen ovale closure in a patient with a large right atrial thrombus and recent paradoxical embolic stroke.
Abstract A 59-year-old male with a history of gallbladder adenocarcinoma receiving chemotherapy and on therapeutic anticoagulation for portal vein thrombosis presented to the emergency department via ambulance after being found unresponsive and in cardiac arrest. Initial workup upon return of spontaneous circulation revealed a large right atrial mass, patent foramen ovale (PFO), and bilateral acute cortical infarctions. This constellation of findings were concerning for PFO-related paradoxical embolic strokes. Given the risk of recurrent paradoxical embolic events and the absolute contraindication to thrombolysis ...
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - February 18, 2021 Category: Radiology Authors: Callese TE, Yang EH, Levi D, Srinivasa RN, Moriarty JM Tags: Diagn Interv Radiol Source Type: research

A Case Series Of Non-Bacterial Thrombotic Endocarditis Associated With Gynecological Malignancies (P6.248)
Conclusions:NBTE is an important ischemic stroke mechanism. We have reported three cases where the underlying malignancy was gynecological (endometrial, ovarian, and cervical). In the first two cases, the malignancy was discovered during the investigations for the stroke mechanism, while the third had a known underlying malignancy. This series highlights the need to consider gynecological malignancies as an underlying cause of stroke in young women; and that the ischemic event can occur prior to the malignancy diagnosis.Disclosure: Dr. Schabas has nothing to disclose. Dr.Teal has received personal compensation for activiti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Schabas, A., Teal, P., Yip, S., Mann, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review
Abstract: Stroke is a dramatic complication of pancreatic cancer with mechanisms related to oncological disease. A better description of the characteristics of cerebrovascular events would help better understand the pathogeny and protect vulnerable patients. We thus conducted a descriptive analysis of clinical, biological, and radiological features of patients from our centers and literature. We reviewed consecutive cases of patients who presented cerebrovascular events and pancreatic cancer in 4 stroke units in Lorrain (France) between January 1, 2009 and March 31, 2015, and all reported cases of literature. We identifie...
Source: Medicine - June 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Middle cerebral artery infarction in a cancer patient: a fatal case of Trousseau's syndrome.
This report describes a young, previously healthy man diagnosed to have an acute middle cerebral arterial ischaemic stroke and lower-limb deep vein thrombosis, who subsequently succumbed to pulmonary arterial embolism. During the course of his illness, he was diagnosed to have a malignant pleural effusion secondary to an occult adenocarcinoma. This report highlights the need for a high degree of suspicion for occult malignancy and non-bacterial thrombotic endocarditis in young (<60 years old) ischaemic stroke patients with no identifiable conventional cardiovascular risks. In selected patients, transoesophageal echocard...
Source: Hong Kong Med J - February 1, 2014 Category: Journals (General) Authors: Woo PY, Chan DT, Cheung TC, Zhu XL, Poon WS Tags: Hong Kong Med J Source Type: research

The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation.
In this study, we explored the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) in the process of BBR-induced inhibition of HMGB1 in ischemic brain. Before the 60-min MCAO surgery, the mice were pretreated with BBR (50 mg· kg-1 per day, ig) for 14 days or ICV injected with specific lentiviral vector or shRNA. We showed that MCAO caused marked increase in the expression Malat1 and HMGB1 in the ipsilateral cortex, which was significantly attenuated by pretreatment with BBR. Knockdown of Malat1 attenuated the inflammatory injury after brain ischemia, whereas overexpression of Malat1 exacerba...
Source: Acta Pharmacologica Sinica - August 19, 2019 Category: Drugs & Pharmacology Authors: Cao DW, Liu MM, Duan R, Tao YF, Zhou JS, Fang WR, Zhu JR, Niu L, Sun JG Tags: Acta Pharmacol Sin Source Type: research

LncRNA-Malat1 promoting inflammatory response aggravates cerebral ischemia-reperfusion neuronal injury in rats by targeting miR-211-5p
CONCLUSION: Higher expression of LncRNA-Malat1 was involved in neuronal injury, LncRNA-Malat1 knockdown may reduce inflammation and apoptosis by modulating miR-211-5p, which provided a new therapeutic strategy for clinical stroke intervention targets.PMID:34324865 | DOI:10.1016/j.bcp.2021.114694
Source: Biochemical Pharmacology - July 29, 2021 Category: Drugs & Pharmacology Authors: Xiaodan Tan Wenjia Guo Zhe Peng Chao Gu Pu Xiang Yunjun Tu Huizhi Fei Xia Liu Yi Lu Miaomiao Li Hong Wang Ying Luo Junqing Yang Source Type: research

P2-33-4 * lung cancer chemotherapy in patients undergoing daialysis
Conclusion: Chemotherapy for lung cancer patients undergoing dialysis were associated with severe hematological toxicity.It is urgent task to establish optimal cancer chemotherapy and management of adverse events.
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Sato, K., Kuriyama, H., Sakamoto, H., Ebe, Y., Koike, T. Tags: Poster Session (Poster presentations categorized by each organ) Source Type: research

UK 'among worst' for cancer linked to obesity
Conclusion This international study has shown alarming increases in cases of cancer that can be attributed to high BMI. Overall, they estimated that 3.6% of cancers in adults (aged over 30 years) worldwide are caused by high BMI, with the proportion attributed to obesity slightly higher in women than in men. In the UK, 4.4% of all cases of cancer per year in men and 8.2% of all cases of cancer per year in women, were estimated to be attributable to obesity. The research focused on cancers that the WCRF has already established are linked to high BMI. When looking at these cancers, the UK was joint second highest in the worl...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Cancer Obesity Source Type: news

Bilateral cerebral embolism as a characteristic feature of patients with Trousseau syndrome
This study suggests that bilateral infarctions presenting microembolisms are important features of cerebral embolism attributed to Trousseau syndrome.
Source: Journal of Clinical Neuroscience - June 29, 2017 Category: Neuroscience Source Type: research

Severe Symptoms, but a Truly Treatable Disease
BY NOURA MAHDI; DARRON LEWIS; JEREMY OSBORNE; & AHMED RAZIUDDIN, MDA 73-year-old man was brought to the emergency department from his nursing home for rectal bleeding and anemia. The patient mentioned he had had episodes of bright red rectal bleeding and constipation for a few months. A colonoscopy had been done prior to the visit, which revealed a large intestine tumor and biopsy confirming adenocarcinoma. He was awaiting an appointment with his surgeon.The patient reported bloody rectal leakage, and a CBC done at the nursing home showed a hemoglobin level of 7.2. He also complained of dyspnea but denied any other ...
Source: The Case Files - March 20, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Synchronous cerebral arteriovenous malformation and lung adenocarcinoma carcinoma brain metastases: A case study and literature review.
CONCLUSION: This case represents a previously undocumented confluence of cranial AVM that initially masked a non-small cell lung cancer brain metastasis. PMID: 30638546 [PubMed - as supplied by publisher]
Source: Neurochirurgie - January 15, 2019 Category: Neurosurgery Tags: Neurochirurgie Source Type: research

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