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Cancer: Adenocarcinoma
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Total 35 results found since Jan 2013.
Colon adenocarcinoma and Birt-Hogg-Dub é syndrome in a young patient: case report and exploration of pathologic implications
Cancer Biol Ther. 2023 Dec 31;24(1):2184153. doi: 10.1080/15384047.2023.2184153.ABSTRACTBirt-Hogg-Dubé syndrome (BHD) is an autosomal dominant disorder caused by germline mutations in the folliculin gene (FLCN) that result in the functional loss of the tumor suppressor folliculin. It is classically associated with cutaneous hamartomas, pulmonary cysts with spontaneous pneumothorax, and various renal cancers. In this case, we present a patient initially diagnosed with chromophobe renal cell carcinoma and subsequently found to have colorectal cancer (CRC). The presence of two separate malignancies in a young patient with a ...
Source: Cancer Biology and Therapy - March 2, 2023 Category: Cancer & Oncology Authors: Grant W Jirka Daniel S Lefler Jessica Russo Babar Bashir Source Type: research
FLOT and CROSS chemotherapy regimens alter the frequency of CD27 < sup > + < /sup > and CD69 < sup > + < /sup > T cells in oesophagogastric adenocarcinomas: implications for combination with immunotherapy
This study investigates the immunostimulatory properties of FLOT, CROSS and MAGIC chemotherapy regimens in the context of OGJ using in vitro and ex vivo models of the treatment-naïve and post-chemotherapy treated tumour microenvironment. FLOT and CROSS chemotherapy regimens increased surrogate markers of immunogenic cell death (HMGB1 and HLA-DR), whereas the MAGIC treatment regimen decreased HMGB1 and HLA-DR on OGJ cells (markedly for epirubicin). Tumour-infiltrating and circulating T cells had significantly lower CD27 expression and significantly higher CD69 expression post-FLOT and post-CROSS treatment. Similarly, the s...
Source: Cell Research - August 20, 2022 Category: Cytology Authors: Maria Davern Noel E Donlon Andrew S Sheppard Klaudia D Majcher Fiona O' Connell Aisling B Heeran Malika Grant Robert A Farrell Conall Hayes Dara Bracken-Clarke Melissa J Conroy Emma Foley Dermot O' Toole Anshul Bhardwaj Narayanasamy Ravi John V Reynolds S Source Type: research
Patterns of care and outcomes of radiotherapy or hormone therapy in patients with medically inoperable endometrial adenocarcinoma
CONCLUSIONS: We identified factors associated with the receipt of RT or HT in medically inoperable endometrial cancer patients. Treatment with RT correlated with improved survival compared to HT in older patients and those treated at lower-volume centers.PMID:34563365 | DOI:10.1016/j.ygyno.2021.09.006
Source: Gynecologic Oncology - September 26, 2021 Category: Cancer & Oncology Authors: Leonid B Reshko Jeremy T Gaskins Abbas Rattani Alyssa A Farley Grant W McKenzie Scott R Silva Source Type: research
Prolonged Complete Response of Early Stage Primary Adenocarcinoma of the Lung to Nivolumab Monotherapy
Clin Oncol Case Rep. 2021 Jan;4(1):157. Epub 2021 Jan 15.ABSTRACTImmune checkpoint inhibitors are currently employed for the treatment of various malignancies, including advanced melanoma and non-small cell lung cancer. As more patients are treated with checkpoint inhibitors, situations will arise in which early-stage disease may be subjected, intentionally or unintentionally, to these agents. This is especially relevant for patients presenting with multiple primary malignant tumors (MPMTs). Here we report the case of a patient presenting synchronously with metastatic melanoma to multiple regional lymph nodes and stage I l...
Source: Clinical Lung Cancer - August 12, 2021 Category: Cancer & Oncology Authors: Serhan Unlu Michael J Grant Scott Gettinger Adebowale Adeniran Harriet M Kluger Source Type: research
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function
Immunology. 2021 Apr 10. doi: 10.1111/imm.13337. Online ahead of print.ABSTRACTCD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively target the immunosuppressive function of Treg cells within tumours without disrupting their systemic anti-inflammatory function. High levels of expression of Chemokine (C-C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues. It has recently been proposed that disruptio...
Source: Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Sarah K Whiteside Francis M Grant David S Gyori Alberto G Conti Charlotte J Imianowski Paula Kuo Rabab Nasrallah Firas Sadiyah Sergio A Lira Frank Tacke Robert L Eil Oliver T Burton James Dooley Adrian Liston Klaus Okkenhaug Jie Yang Rahul Roychoudhuri Source Type: research
