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Cancer: Adenocarcinoma

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Total 766 results found since Jan 2013.

ZNF139 promotes tumor metastasis by increasing migration and invasion in human gastric cancer cells.
Abstract Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cells. Quantitative RT-PCR(QRT-PCR) and Western blot were applied for detection of ZNF139 expression in gastric cancer tissues, adjacent cancer tissues, metastatic lymph nodes, gastric cancer cell lines SGC7901 and BGC823 and gastric epithelial cell line GES-1; siRNA specific to ZNF139 was s...
Source: Neoplasma - May 18, 2014 Category: Cancer & Oncology Authors: Li Y, Tan BB, Zhao Q, Fan LQ, Wang D, Liu Y Tags: Neoplasma Source Type: research

Abstract B114: c-Rel is a critical mediator of NF-{kappa}B dependent TRAIL resistance of pancreatic cancer cells
In conclusion, we were able to delineate a novel c-Rel, NFATc2 and COX-2 dependent anti-apoptotic signalling pathway in PDAC with broad clinical implications for pharmaceutical intervention strategies.Citation Format: Claudia Geismann, Frauke Grohmann, Robert Häsler, Philip Rosenstiel, Günter Schneider, Sebastian Zeissig, Stefan Schreiber, Heiner Schäfer, Alexander Arlt. c-Rel is a critical mediator of NF-κB dependent TRAIL resistance of pancreatic cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Phila...
Source: Cancer Research - June 30, 2015 Category: Cancer & Oncology Authors: Geismann, C., Grohmann, F., Hasler, R., Rosenstiel, P., Schneider, G., Zeissig, S., Schreiber, S., Schafer, H., Arlt, A. Tags: Other Topics Source Type: research

PlGF knockdown inhibited tumor survival and migration in gastric cancer cell via PI3K/Akt and p38MAPK pathways
The molecular signalling of placental growth factor (PlGF), a member of the vascular endothelial growth factor family, was not uncovered in human adenocarcinoma gastric cell line (AGS). The purpose of this study was to examine the inhibitory effects of PlGF knockdown on cell proliferation, apoptosis and migration through p38 mitogen‐activated protein kinase (p38MAPK) and PI3K pathways in human adenocarcinoma gastric cell line (AGS). To study PlGF knockdown effect, AGS cells were treated with 40 pmol of small interfering RNA (siRNA) related to PlGF gene and also a scrambled siRNA as control. Trypan Blue and Anexin V sta...
Source: Cell Biochemistry and Function - March 1, 2016 Category: Biochemistry Authors: Hassan Akrami, Fatemeh Mahmoodi, Somaye Havasi, Amene Sharifi Tags: Research Article Source Type: research

Abstract A35: SOX9 induces chemo-resistance in pancreatic cancer cells and its high expression predicts poor prognosis
Conclusions: These data indicate that Sox9 plays an important role in chemo-resistance by the induction of stemness in pancreatic cancer cells.Citation Format: Shingo Kagawa, Taku Higasihara, Hideyuki Yoshitomi, Shigetsugu Takano, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Katsunori Furukawa, Masaru Miyazaki.{Authors}. SOX9 induces chemo-resistance in pancreatic cancer cells and its high expression predicts poor prognosis. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 S...
Source: Cancer Research - December 13, 2016 Category: Cancer & Oncology Authors: Shingo Kagawa, Taku Higasihara, Hideyuki Yoshitomi, Shigetsugu Takano, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Katsunori Furukawa, Masaru Miyazaki Tags: Early Detection Source Type: research

Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.
Authors: Wang H, Li S, Luo X, Song Z, Long X, Zhu X Abstract Colorectal adenocarcinoma is the third most common cancer worldwide. PARP6, a novel member of the poly(ADP-ribose) polymerases (PARPs) and survivin, a member of the family of inhibitor of apoptosis (IAP) proteins are associated with a poor prognosis in various types of cancers. However, limited evidence exists regarding the interaction between PARP6 and survivin in colorectal adenocarcinoma. In the present study, we used the paired samples of 20 patients with colorectal adenocarcinoma to detect the expression of PARP6 and survivin in both tumor and adjac...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
CONCLUSIONS: BACH1 is overexpressed in prostate cancer. Because this promotes invasion and migration, it may facilitate metastasis of prostate cancer. Thus, BACH1 is a potential therapeutic target for metastatic prostate cancer. BACH1 silencing therapy can be considered as a novel and effective adjuvant in prostate cancer targeted therapies. PMID: 28889753 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - September 12, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Effect of Pim-3 Downregulation on Proliferation and Apoptosis in Lung Adenocarcinoma A549 Cells.
CONCLUSION: The downregulation of Pim-3 was closely related to the activation status of the lung STAT3 signaling pathway, mediated cell proliferation inhibition and induced apoptosis. PMID: 31882428 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - October 31, 2019 Category: Laboratory Medicine Authors: Fan X, Xie Y, Zhang L, Gao X, Han J, Chen Y, Yang J, Li S Tags: Ann Clin Lab Sci Source Type: research

Corrigendum BMI ‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor
Oncol Rep. 2022 Aug;48(2):141. doi: 10.3892/or.2022.8352. Epub 2022 Jun 22.ABSTRACTFollowing the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 5 on p. 1637, the data panel selected to represent the 'Ishikawa/+BMI‑1 siRNA/Invasion' experiment in Fig. 5A appeared to overlap with the data shown for the 'JEC/+BMI‑1 siRNA/Migration' panel in Fig. 5C, such that they were potentially derived from the same original source. The authors have re‑examined their original data, and realize that the data panel selected for the 'Ishikawa/+BMI‑1 siRNA/Invasion' experiment in Fig. ...
Source: Oncology Reports - June 22, 2022 Category: Cancer & Oncology Authors: Jing Yu Ling Chen Zhenhua Bao Ying Liu Guohong Liu Fengling Li Lianqin Li Source Type: research

STAMBPL1 promotes the progression of lung adenocarcinoma by inhibiting DHRS2 expression
CONCLUSIONS: The expression of STAMBPL1 mRNA is significantly up-regulated in LUAD, promoting the progression of LUAD by down-regulating the expression of DHRS2 and acting as a potential biomarker of LUAD.PMID:37393834 | DOI:10.1016/j.tranon.2023.101728
Source: Translational Oncology - July 2, 2023 Category: Cancer & Oncology Authors: Xiang Yang Liqun Ling Changhong Li Tianqi Hu Chenkang Zhou Jian Chen Yumin Wang Lijuan Hu Source Type: research