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Cancer: Adenocarcinoma

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Total 766 results found since Jan 2013.

Thymidine phosphorylase induction by ionizing radiation antagonizes 5-fluorouracil resistance in human ductal pancreatic adenocarcinoma
Radiat Environ Biophys. 2022 Jan 27. doi: 10.1007/s00411-022-00962-w. Online ahead of print.ABSTRACTChemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties of 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that upregulation of thymidine phosphorylase (TP) by IR reverses FU chemoresistance in PDAC cells. The FU resistant variant of the human PDAC cell line AsPC-1 (FU-R) was used to determine the sensitizing effects of IR. Proliferation rat...
Source: Radiation and Environmental Biophysics - January 27, 2022 Category: Physics Authors: Lucas D Lee Ioannis Pozios Verena Liu Silke B Nachbichler Dirk B öhmer Carsten Kamphues Katharina Beyer Christiane J Bruns Martin E Kreis Hendrik Seeliger Source Type: research

Annotation and functional characterization of long noncoding RNAs deregulated in pancreatic adenocarcinoma
ConclusionsOur study expands the repertoire of lncRNAs deregulated in PDAC, thereby revealing novel candidate biomarkers for patient risk stratification. It also provides a roadmap for functional assays aimed to characterize novel mechanisms of action of lncRNAs in pancreatic cancer, which could be explored for therapeutic development.
Source: Cellular Oncology - May 14, 2022 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 14, Pages 2543: Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma
ipathi Hiroyuki Katayama Luisa Maren Solis Soto Jaime Rodriguez-Canales Carmen Behrens Ignacio Wistuba Samir Hanash Edwin J. Ostrin Activation of the NRF2 pathway through gain-of-function mutations or loss-of-function of its suppressor KEAP1 is a frequent finding in lung cancer. NRF2 activation has been reported to alter the tumor microenvironment. Here, we demonstrated that NRF2 alters tryptophan metabolism through the kynurenine pathway that is associated with a tumor-promoting, immune suppressed microenvironment. Specifically, proteomic profiles of 47 lung adenocarcinoma (LUAD) cell lines (11 KEAP1 mut...
Source: Cancers - May 21, 2022 Category: Cancer & Oncology Authors: Johannes F. Fahrmann Ichidai Tanaka Ehsan Irajizad Xiangying Mao Jennifer B. Dennison Eunice Murage Julian Casabar Jeffrey Mayo Qian Peng Muge Celiktas Jody V. Vykoukal Soyoung Park Ayumu Taguchi Oliver Delgado Satyendra C. Tripathi Hiroyuki Katayama Luis Tags: Article Source Type: research

The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma
Cell Mol Biol (Noisy-le-grand). 2022 May 22;68(1):130-139. doi: 10.14715/cmb/2022.68.1.17.ABSTRACTN6-methyladenosine (m6A) is the most common internal modification in mammalian mRNAs while RNA-binding motif protein 15 (RBM15) is an important methyltransferase in m6A modification. Increasing evidences have shown that RBM15 has a close correlation with lung cancer. However, specific functions of RBM15 in lung adenocarcinoma (LUAD) are limited. RBM15 expression was analyzed in human LUAD tissues and matched healthy lung tissue. RBM15 was knocked down via siRNA in A549 and H1734 cells. The relationships between RBM15 with cell...
Source: Cellular and Molecular Biology - July 9, 2022 Category: Molecular Biology Authors: Mingsheng Ma Wei Wang Biying Wang Yichen Yang Yunchao Huang Guangqiang Zhao Lianhua Ye Source Type: research

Cancers, Vol. 14, Pages 3726: Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches
In conclusion, a compound screen together with a functional genomic approach identified Src as a potential chemosensitising target in OAC, which could be assessed in a clinical study for poor prognosis OAC patients.
Source: Cancers - July 30, 2022 Category: Cancer & Oncology Authors: Niamh H. McCabe Leanne Stevenson Enya Scanlon Rosalie Douglas Susanna Kennedy Oliver Keminer Bj örn Windshügel Daniela Zisterer Richard D. Kennedy Jaine K. Blayney Richard C. Turkington Tags: Article Source Type: research

Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells
CONCLUSIONS: Data provided suggest that TGFβ1 modulates the expression of DUSP genes and that upregulation of DUSP26 may be required for TGFβ1-promoted EMT in A549 and PANC1 cells. Further studies should be carried out to elucidate the requirement of individual DUSPs in TGFβ1-associated EMT in tumor cells.PMID:36053282 | DOI:10.1007/s11033-022-07893-1
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Sabire Guler Berrin Zik Abdullah Yalcin Source Type: research