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BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate
CONCLUSIONS: BMP4 enhances cell migration and promotes cell EMT through Smad1 signaling pathway. Abnormal BMP4 mediates migration and EMT through other relevant signaling pathways resulting in NSCL/P. The study provides new insight into the mechanisms of NSCL/P associated with BMP4.n.PMID:35702016 | DOI:10.1177/10556656221105762
Source: The Cleft Palate-Craniofacial Journal - June 15, 2022 Category: ENT & OMF Authors: Jia-Wei Hong Yue Yu Lu-Shan Wang Zheng Li Rui Zhang Qi Wang Zhen Ding Jin-Peng Zhang Mei-Rong Zhang Li-Chun Xu Source Type: research

Nucleic Acids Delivery Into the Cells Using Pro-Apoptotic Protein Lactaptin
Cell penetrating peptides (CPP) are promising agents for transporting diverse cargo into the cells. The amino acid sequence and the mechanism of lactaptin entry into the cells allow it to be included into CPP group. Lactaptin, the fragment of human milk kappa-casein, and recombinant lactaptin (RL2) were initially discovered as molecules that induced apoptosis of cultured cancer cells and did not affect non-malignant cells. Here, we analyzed the recombinant lactaptin potency to form complexes with nucleic acids and to act as a gene delivery system. To study RL2-dependent delivery, three type of nucleic acid were used as a m...
Source: Frontiers in Pharmacology - September 17, 2019 Category: Drugs & Pharmacology Source Type: research

Expression of B cell-specific Moloney murine leukemia virus integration site 1 in vulvar squamous cell carcinoma and its effect on the biological behavior of A-431 cells.
Authors: Bai X, Ouyang L, Li BO, Zhou Y, Wen X Abstract The aim of the present study was to investigate the expression of B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) in vulvar squamous cell carcinoma (VSCC) and vulvar intraepithelial neoplasia (VIN). Furthermore, the present study investigated the effects of BMI-1 expression on the biological behavior of A-431 human epidermoid carcinoma cells. BMI-1 expression in human VSCC and VIN tissues was detected using immunohistochemistry. Subsequently, BMI-1 expression was silenced in A-431 cells using small interfering RNA (siRNA), and BMI-1 ex...
Source: Oncology Letters - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

P133
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): A. Cherepanova, V. Vlassov, P. Laktionov The strong connection between cancer-related inflammation and tumour development with pattern – recognizing receptors (PRRs) activation results in identification of new target molecules that could lead to improved cancer diagnosis and treatment. TLR3, RIG1 and MDA5 synthetic ligand poly(I:C) was shown to trigger apoptosis in cancer cells. However, TLR3 signaling also includes NF-kB transcription factor which has emerged as endogenous tumour promoter via stimulation of ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research