Filtered By:
Cancer: Skin Cancer
Procedure: Gastroschisis Repair
This page shows you your search results in order of date.
Order by Relevance | Date
Total 616 results found since Jan 2013.
Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma
Cancer Res. 2023 Sep 20. doi: 10.1158/0008-5472.CAN-23-0485. Online ahead of print.ABSTRACTMetastatic melanoma is either intrinsically resistant or rapidly acquires resistance to targeted therapy treatments, such as MAPK inhibitors. A leading cause of resistance to targeted therapy is a dynamic transition of melanoma cells from a proliferative to a highly invasive state, a phenomenon called phenotype switching. Mechanisms regulating phenotype switching represent potential targets for improving treatment of melanoma patients. Using a drug screen targeting chromatin regulators in patient-derived 3D MAPK inhibitor-resistant m...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Lorenza P Ferretti Flurina B öhi Deena M Leslie Pedrioli Phil F Cheng Elena Ferrari Petra Baumgaertner Abdiel Alvarado-Diaz Federica Sella Alessandra Cereghetti Patrick Turko Roni H Wright Katrien De Bock Daniel E Speiser Roberto Ferrari Mitchell P Leves Source Type: research
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity
Toxicol Appl Pharmacol. 2023 Sep 14:116688. doi: 10.1016/j.taap.2023.116688. Online ahead of print.ABSTRACTChemical modifications in messenger RNA (mRNA) regulate gene expression and play critical roles in stress responses and diseases. Recently we have shown that N6-methyladenosine (m6A), the most abundant mRNA modification, promotes the repair of UVB-induced DNA damage by regulating global genome nucleotide excision repair (GG-NER). However, the roles of other mRNA modifications in the UVB-induced damage response remain understudied. N4-acetylcytidine (ac4C) is deposited in mRNA by the RNA-binding acetyltransferase NAT10...
Source: Toxicology and Applied Pharmacology - September 16, 2023 Category: Toxicology Authors: Zizhao Yang Emma Wilkinson Yan-Hong Cui Haixia Li Yu-Ying He Source Type: research
Comprehensive analysis of P2Y family genes expression, immune characteristics, and prognosis in pan-cancer
CONCLUSION: P2Ys may be used as potential pan-cancer biomarkers in prognosis and immunology. They may also be new targets for tumor immunotherapy, which has wide clinical implications.PMID:37672858 | DOI:10.1016/j.tranon.2023.101776
Source: Translational Oncology - September 6, 2023 Category: Cancer & Oncology Authors: Chuan Liu Xiaoli Wang Siwei Wang Jiankang Xiang Huabing Xie Zongbiao Tan Xinshu Li Jixiang Zhang Weiguo Dong Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
HYDIN mutation status as a potential predictor of immune checkpoint inhibitor efficacy in melanoma
CONCLUSIONS: HYDIN mutations are a potential predictive biomarker of ICIs efficacy in melanoma patients.PMID:37595251 | DOI:10.18632/aging.204925
Source: Aging - August 18, 2023 Category: Biomedical Science Authors: Liu Li Kuang Tianrui Li Chunlei Qiu Zhendong Chen Xiaoyan Deng Wenhong Source Type: research
Systematic review on gene-sun exposure interactions in skin cancer
CONCLUSION: Sun exposure seems to interact with genes involved in pigmentation, oxidative stress and immunosuppression, indicating that excessive UV exposure might exhaust oxidative defence and repair systems differentially, dependent on genetic make-up. Further research is warranted to better understand skin cancer epidemiology and develop sun exposure recommendations. A genome-wide approach is recommended as it might uncover unknown disease pathways dependent on UV radiation.PMID:37537768 | DOI:10.1002/mgg3.2259
Source: Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Rasha Shraim Mohamed Ziad Farran George He Jelena Marunica Karsaj Lina Zgaga Ross McManus Source Type: research
