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Cancer: Skin Cancer

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Demographic disparities in receipt of care at a comprehensive cancer center
ConclusionsWe observed racial and ethnic differences in timing of receipt of care at MCC. Future studies should aim to identify contributing factors for the development of novel mitigation strategies and assess whether timing differences in referral to an NCICC correlate with long-term patient outcomes.
Source: Cancer Medicine - April 28, 2023 Category: Cancer & Oncology Authors: Kedar Kirtane, Yayi Zhao, Rossybelle P. Amorrortu, Lindsay N. Fuzzell, Susan T. Vadaparampil, Dana E. Rollison Tags: RESEARCH ARTICLE Source Type: research

A systematic review with evidence mapping of supportive care interventions for melanoma patients and caregivers
With increasing global incidence and survival rates, the number of people living with a previous diagnosis of melanoma is expected to grow in coming years. People diagnosed with melanoma, as well as their caregivers, often report decreased quality of life and daily functioning as a result of diagnosis and the adverse effects of treatment. We performed a systematic review with evidence gap mapping to synthesize the available evidence regarding the effectiveness of supportive care interventions for melanoma patients and their caregivers. AbstractAimWe conducted a systematic review and evidence gap mapping to explore the exis...
Source: Cancer Medicine - April 29, 2023 Category: Cancer & Oncology Authors: Jake R. Thompson, Rehana A. Salam, Sarah Hanna, Mbathio Dieng, Robyn P. M. Saw, Iris Bartula Tags: RESEARCH ARTICLE Source Type: research

Pediatric Melanoma: Geographic Trends in Incidence, Stage, and Mortality in the United States
The objective of this study was to use the surveillance, epidemiology, and end results SEER database to study geographic trends in incidence, staging, and mortality of pediatric melanoma between 2009 and 2019 and determine their relation to UV index in the United States.
Source: Journal of Surgical Research - June 6, 2023 Category: Surgery Authors: Abhilasha Borad, Ellie Deianni, Kayla Pe ña, Sathyaprasad Burjonrappa Tags: Pediatric Surgery Source Type: research

Effect of a web-based curriculum on primary care practice: basic skin cancer triage trial.
CONCLUSIONS: Given previous success with our in-person course, the features required to make WBL a more effective tool for medical education must be further explored. PMID: 24129868 [PubMed - in process]
Source: Famly Medicine - September 1, 2013 Category: Primary Care Authors: Markova A, Weinstock MA, Risica P, Kirtania U, Shaikh W, Ombao H, Chambers CV, Kabango ML, Kallail JK, Post D Tags: Fam Med Source Type: research

Melanoma incidence rises for children and adolescents: An epidemiologic review of pediatric melanoma in the United States
This study was conducted to determine the influence of age on disease presentation and evaluate the change in pediatric melanoma incidence between 1998 and 2007.Methods: We performed a retrospective review of all children ≤18years with cutaneous melanoma who were included in the 2007 National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2007.Results: We identified a total of 1447 patients with cutaneous melanoma. The overall average annual melanoma incidence was 5.4 per 1 million children and adolescents in the U.S., which increased throughout the study period. Most patien...
Source: Journal of Pediatric Surgery - November 1, 2013 Category: Surgery Authors: Mary T. Austin, Yan Xing, Andrea A. Hayes-Jordan, Kevin P. Lally, Janice N. Cormier Tags: Original Articles Source Type: research

Phototoxic dermatoses in pediatric BMT patients receiving voriconazole
We investigated the incidence of phototoxic skin reactions in pediatric BMT recipients treated with voriconazole. Nine out of 40 patients (22.5%), all Caucasian, developed skin lesions in sun‐exposed distributions. Dermatologic findings included sunburn‐like erythema, pseudo‐porphyria, linear papulovesicular lesions, severe erosive cheilitis, dermatoheliosis and lentigines. Patients were treated with sun avoidance, high‐potency sunscreens, and topical steroids with significant improvement in all cases. Prolonged voriconazole use requires close monitoring for chronic skin toxicities. Long‐term risks including the ...
Source: Pediatric Blood and Cancer - March 11, 2014 Category: Cancer & Oncology Authors: Rakesh K. Goyal, Robin P. Gehris, Denise Howrie, Kayla M. Cogley, Randy M. Windreich, Raman Venkataramanan Tags: Brief Report Source Type: research

Initial testing (stage 1) of glembatumumab vedotin (CDX‐011) by the pediatric preclinical testing program
ConclusionsGlembatumumab vedotin yielded high‐level activity against three of six osteosarcoma xenografts, with evidence for response being related to GPNMB expression levels. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - June 10, 2014 Category: Cancer & Oncology Authors: E. Anders Kolb, Richard Gorlick, Catherine A. Billups, Thomas Hawthorne, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith Tags: Research Article Source Type: research

Sentinel Node Biopsy in Pediatric Patients: The Experience in a Single Institution
We report our experience with 29 patients who were evaluated with SLNB during the past 12 years: 9 alveolar rhabdomyosarcoma, 1 embryonal rhabdomyosarcoma, 7 Ewing Sarcoma/pPNET, 1 clear cells sarcoma, 2 epithelioid sarcoma, 1 epithelioid sclerosing fibrosarcoma, 3 myxoid liposarcoma, 1 adult fibrosarcoma, 1 malignant peripheral nerve sheath tumor, 1 undifferentiated sarcoma, 1 sarcoma not otherwise specified, and 1 melanoma. All, but one, patients underwent a lymphoscintigraphy, and in more than half of the patients, an intraoperative lymphatic mapping with a blue dye injection was performed. In our experience, SLNB was a...
Source: European Journal of Pediatric Surgery - December 5, 2014 Category: Surgery Authors: Dall'Igna, PatriziaDe Corti, FedericaAlaggio, RitaCecchetto, Giovanni Tags: Original Article Source Type: research

Dermatological disease in the older age group: a cross-sectional study in aged care facilities
Conclusions A high rate of dermatological disease was found. Findings ranged from frequent but not life-threatening conditions (eg, onychomycosis), to those associated with a significant morbidity (eg, eczema, lichen sclerosus and bullous pemphigoid), to potentially life-threatening (eg, squamous cell carcinoma, melanoma and breast cancer). Those with less significant physical impairment were found to be at greater risk of inflammatory dermatoses.
Source: BMJ Open - December 23, 2015 Category: Journals (General) Authors: Deo, M. S., Kerse, N., Vandal, A. C., Jarrett, P. Tags: Open access, Dermatology, Geriatric medicine Research Source Type: research

Multicenter questionnaire survey on patterns of care for elderly patients with esophageal squamous cell carcinoma by the Japan Esophageal Oncology Group
Conclusions Fit healthy elderly were considered the same as non-elderly patients, although there are no established treatment selection criteria. Radiation alone plays most important role in the treatment for vulnerable and frail esophageal squamous cell carcinoma patients. Stage II/III (non-T4) disease is attractive and warranted for future investigations.
Source: Japanese Journal of Clinical Oncology - January 28, 2016 Category: Cancer & Oncology Authors: Hamamoto, Y., Akutsu, Y., Nagashima, F., Hironaka, S., Ito, Y., Kato, K., Hara, H., Tsubosa, Y., Nakagawa, S., Daiko, H., Ozawa, S., Kitagawa, Y. Tags: Gastrointestinal Medicine, Original Articles Source Type: research

Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma
Sentinel lymph node biopsy (SLNB)-based management has been shown to improve disease-free survival in adult melanoma, but there is scant evidence regarding the utility of SLNB in pediatric melanoma.
Source: Journal of Pediatric Surgery - March 30, 2016 Category: Surgery Authors: Jina Kim, Zhifei Sun, Brian C. Gulack, Mohamed A. Adam, Paul J. Mosca, Henry E. Rice, Elisabeth T. Tracy Source Type: research

Cutaneous malignant melanoma in children and adolescents treated in pediatric oncology units
ConclusionsMM appears to be different in prepubescent children, of whom most had a spitzoid histotype. Diagnosis can be difficult, leading to delay in treatment. New biological tools to identify targets for treatment in MM and to differentiate spitzoid melanomas from Spitz nevi now exist. As effective targeted therapies are now available, we recommend requesting biological examination of all melanocyte‐derived skin lesions in children that could be malignant.
Source: Pediatric Blood and Cancer - June 27, 2016 Category: Cancer & Oncology Authors: Yves Réguerre, Marie Vittaz, Daniel Orbach, Caroline Robert, Christine Bodemer, Christina Mateus, Dominique Plantaz, Emmanuel Plouvier, Patrick Lutz, Josue Rakotonjanahary, Sylvie Fraitag, Ludovic Martin Tags: Research Article Source Type: research

Systematic review and individual patient data analysis of pediatric head and neck squamous cell carcinoma: An analysis of 217 cases
Pediatric head and neck Squamous cell carcinoma (PHNSCC) is a rare disease. The optimum treatment and outcome remains poorly understood because of rarity.
Source: International Journal of Pediatric Otorhinolaryngology - November 10, 2016 Category: ENT & OMF Authors: V. Bhanu Prasad, Supriya Mallick, Ashish Dutt Upadhyay, G.K. Rath Source Type: research

Pediatric laryngeal carcinoma in a heterozygous carrier of Fanconi anemia
Abstract A case of invasive, keratinizing squamous cell carcinoma of the larynx in an 8‐year‐old female treated with laryngectomy is presented. Perinatal exposure to human papilloma virus and constitutional heterozygosity for a FANCC mutation were identified, though FANCC heterozygosity is not known to be cancer predisposing. An additional tumor‐associated mutation in NOTCH1 was also identified potentially contributing to oncogenesis. This case illustrates an exceedingly rare type of cancer in the pediatric population and discusses diagnostic workup, evaluation of risk factors for head and neck cancer, and treatment options.
Source: Pediatric Blood and Cancer - January 30, 2017 Category: Cancer & Oncology Authors: A. M. D'Souza, J. Mark, M. Demarcantonio, D. Leino, R. Sisson, J. I. Geller Tags: Brief Report Source Type: research

Nivolumab in the Treatment of Refractory Pediatric Hodgkin Lymphoma
The programmed death-1 (PD-1) pathway of immune evasion is exploited by many malignancies to limit host T-cell-mediated immune responses. Nivolumab is a PD-1-blocking monoclonal antibody that disrupts this pathway and is FDA approved for the treatment of metastatic melanoma, renal cell carcinoma, and squamous non–small cell lung cancer. In this case report, we describe the first published pediatric experience of nivolumab in refractory classic Hodgkin lymphoma. In this patient with primary refractory disease and high disease burden, cytokine release syndrome requiring inotropic support developed following the first infus...
Source: Journal of Pediatric Hematology Oncology - June 24, 2017 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research