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Cancer: Skin Cancer
Nutrition: Zinc
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Total 120 results found since Jan 2013.
METTL3 Promotes the Growth and Invasion of Melanoma Cells by Regulating the lncRNA SNHG3/miR-330-5p Axis
In conclusion, our findings demonstrated that METTL3-mediated m6A modification of lncRNA SNHG3 promoted the growth and invasion of melanoma cells by regulating the miR-330-5p/CNBP axis.PMID:37606168 | DOI:10.1177/09636897231188300
Source: Cell Transplantation - August 22, 2023 Category: Cytology Authors: Shaojun Chu Yulong Li Baojin Wu Guo Rong Qiang Hou Qin Zhou Dexiang Du Yufei Li Source Type: research
ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous cell carcinoma cells through m6A-dependent modification
This study aimed to reveal the intrinsic mechanism by which the DUOX1-zinc-finger CCCH domain-containing protein 13 (ZC3H13) ferroptosis axis affected the LSCC process. GEPIA was used to investigate the expression of DUOX1 in LSCC, and the expression levels of DUOX1 and ZC3H13 were manipulated by overexpression and RNA interference. MTT assay was used to detect cell proliferation. Chromatin immunoprecipitation (CHIP) detected the binding of DUOX1 and ZC3H13, and ROS assessment and intracellular Fe2+ content determination were performed to examine the ferroptosis. MeRIP was used to analyze the m6A methylation of DUOX1. Ferr...
Source: Tissue and Cell - August 3, 2023 Category: Cytology Authors: Lili Huang Guangli Chen Jing He Pu Wang Source Type: research
Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma
This study aimed to determine the expression pattern and functional role of DPP3 in ESCC. DPP3 expression was assessed in normal and tumor tissues using qRT-PCR and corroborated with ESCC gene expression datasets from GEO and TCGA. DPP3 stable knockdown was performed in ESCC cells by shRNA and its effect on cell proliferation, migration, cell cycle, apoptosis, and activation of nuclear factor erythroid 2- related factor 2 (NRF2) pathway was assessed. The results suggested that DPP3 knockdown lead to reduced proliferation, increased apoptosis, and inhibited migration of ESCC cells. Additionally, DPP3 knockdown led to downre...
Source: Bioscience Reports - August 2, 2023 Category: Biomedical Science Authors: Mohit Arora Sarita Kumari Lokesh Kadian Anupa G Jay Singh Anurag Kumar Deepika Verma Raja Pramanik Sunil Kumar Rajni Yadav Anita Chopra Shyam S Chauhan Source Type: research
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth
Pharmacol Res. 2023 Jul 18:106858. doi: 10.1016/j.phrs.2023.106858. Online ahead of print.ABSTRACTAberrant activation of Hedgehog (HH) signaling in cancer is the result of genetic alterations of upstream pathway components (canonical) or other oncogenic mechanisms (noncanonical), that ultimately concur to activate the zinc-finger transcription factors GLI1 and GLI2. Therefore, inhibition of GLI activity is a good therapeutic option to suppress both canonical and noncanonical activation of the HH pathway. However, only a few GLI inhibitors are available, and none of them have the profile required for clinical development du...
Source: Cell Research - July 20, 2023 Category: Cytology Authors: Luisa Maresca Enrica Crivaro Francesca Migliorini Giulia Anichini Alessandro Giammona Sara Pepe Federica Poggialini Chiara Vagaggini Giuseppe Giannini Serena Sestini Lorenzo Borgognoni Andrea Lapucci Elena Dreassi Maurizio Taddei Fabrizio Manetti Elena Pe Source Type: research
Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow's Health cohort
CONCLUSION: History of cancer diagnosis was associated with specific profiles of arsenic species and metallome. Our results indicate that arsenic methylation and zinc levels, as measured in toenails, may be an important biomarker for cancer prevalence. Further research is needed to use toenails as a prognostic measure of arsenic-and other metal-induced cancer.PMID:37397723 | PMC:PMC10308375 | DOI:10.3389/fpubh.2023.1148283
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Kalli M Hood Ellen Sweeney Gabriela Ilie Erin Keltie Jong Sung Kim Source Type: research
