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Differences in Thymus and Activation-Regulated Chemokine and Squamous Cell Carcinoma Antigen 2 Levels in Food Protein-Induced Enterocolitis Syndrome and Atopic Dermatitis
Conclusion: Assessing the relative TARC/SCCA2 ratio may help predict whether elevated TARC levels measured after vomiting are caused by FPIES or AD.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - May 10, 2022 Category: Allergy & Immunology Source Type: research

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Spring health cheat sheet
As the spring weather approaches, many common winter infections recede. However, warmer temperatures can introduce a new set of health challenges. As trees and flowers bloom and grass grows, susceptible children will start to display symptoms of seasonal allergies, triggering flares of asthma and eczema. And, As children spend more time outdoors, parents also need to watch for exposure to ticks, poison ivy and excess sun. Here are a few tips to keeping your child healthy this spring. Seasonal allergies: What can you do? During allergy season: have your child bathe after spending time outdoors to remove allergens fro...
Source: Thrive, Children's Hospital Boston - April 7, 2017 Category: Pediatrics Authors: Carolyn Sax Tags: Health & Wellness Parenting allergies asthma Carolyn Sax conjunctivitis lyme disease sunburn Source Type: news

Beneficial IFN-α treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency
Autosomal-recessive hyper-IgE syndrome (AR-HIES) is a rare primary immunodeficiency caused by loss-of-function mutations in the gene DOCK8 (dedicator of cytokinesis 8). HIES follows an autosomal-dominant or -recessive trait and is characterized by high serum IgE levels, eczema, recurrent respiratory and skin infections, and fungal infections. Allergic disease manifestations, viral infections, and an elevated risk of squamous cell carcinoma and lymphoma are characteristics of DOCK8 deficiency. Lymphopenia, insufficient T- and B-cell memory compartment, impaired lymphocyte proliferation to mitogens, and natural killer (NK) c...
Source: Journal of Allergy and Clinical Immunology - April 3, 2014 Category: Allergy & Immunology Authors: Cihan Papan, Beate Hagl, Valerie Heinz, Michael H. Albert, Oliver Ehrt, Julie Sawalle-Belohradsky, Jens Neumann, Martin Ries, Philip Bufler, Andreas Wollenberg, Ellen D. Renner Tags: Letters to the Editor Source Type: research