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Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancers, Vol. 12, Pages 1120: The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-small Cell Lung Cancer: A Systematic Review
This study aimed to systematically search for studies reporting on the use of liquid biopsies (LB), the correlation between LBs and tissue biopsies, and finally the predictive value in the management of NSCLC. A systematic literature search was performed, including results published after 1 January 2014. Articles studying the predictive value or validity of a LB were included. The search (up to 1 September 2019) retrieved 1704 articles, 1323 articles were excluded after title and abstract screening. Remaining articles were assessed for eligibility by full-text review. After full-text review, 64 articles investigating the p...
Source: Cancers - April 29, 2020 Category: Cancer & Oncology Authors: Frederik van Delft Hendrik Koffijberg Valesca Ret èl Michel van den Heuvel Maarten IJzerman Tags: Review Source Type: research
Public Interest in Textured Breast Implants Recall: A Google Trends Analysis
ConclusionsGT data correlate with shifts in real-world health care utilization and public interest caused by high-profile media coverage, making it a useful tool for providers for real-time prediction of trends in public health in response to observable influences.Level of Evidence VThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266.
Source: Aesthetic Plastic Surgery - April 29, 2020 Category: Cosmetic Surgery Source Type: research
Systematic review of the Utilization of PERCIST 1.0 metabolic response criteria in prospective clinical trials.
Conclusions: Since its introduction, PERCIST 1.0 has been increasingly used in many clinical trials and prospective studies, with variable reporting of metabolic response and survival data. In general, it appears PERCIST response is associated with longer PFS and survival though the heterogeneity of disease, scan timing and therapies make data pooling difficult. Prospective inclusion of the PERCIST 1.0 criteria in clinical trials using FDG, with baseline, early monitoring, and end of therapy scans could inform cancer clinical trials. Support: 5U01CA140204-04 Reference: 1. Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Mhlanga, J., Crandall, J., Ash, L., Kasal, K., Doering, M., Wahl, R. Tags: NET and Others II Source Type: research
Hodgkin lymphoma involving extranodal sites in head and neck: report of twenty-nine cases and review of three-hundred and fifty-seven cases.
CONCLUSION: This largest report showed that HL involving extranodal head and neck sites is not very uncommon and has excellent prognosis.
PMID: 33478377 [PubMed - in process]
Source: Hematology - January 24, 2021 Category: Hematology Tags: Hematology Source Type: research
Proton Beam Therapy for Cancer in Children and Adults: A Health Technology Assessment
CONCLUSIONS: Proton beam therapy may be as effective as conventional radiation therapy, and it may cause fewer side effects, especially for children with brain tumours and for adults with certain types of cancer. Based on published economic evidence, proton beam therapy is likely cost-effective compared with photon therapy in children with medulloblastoma, but cost-effectiveness is unclear in children and adults with other clinical indications. We estimate that publicly funding a proton beam therapy centre in Ontario would result in additional costs of $124.8 million over the next 5 years, but with a six- to seven-fold red...
Source: Ontario Health Technology Assessment Series - May 31, 2021 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research
