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Nutrition: Herbs
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Total 77 results found since Jan 2013.
Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia
Eur J Pharmacol. 2023 Aug 2:175957. doi: 10.1016/j.ejphar.2023.175957. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) is a highly heterogeneous and rapidly progressive hematopoietic neoplasm characterized by frequent relapses and variable prognoses. The development of new treatment options, therefore, is of crucial importance. Platycodin D (PD) is a triterpenoid saponin, extracted from the roots of the traditional Chinese herbal medicine Platycodon grandiflorum (Jacq.) A. DC., which has been reported to exhibit therapeutic potential against a broad range of cancers. Although the effects of PD on AML remain uncl...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Xia Jiang Ye Lin Mengting Zhao Youhong Li Peipei Ye Renzhi Pei Ying Lu Lei Jiang Source Type: research
Nanoemulsion-Based System as a Novel and Promising Approach for Enhancing the Antimicrobial and Antitumoral Activity of Thymus vulgaris (L.) Oil in Human Hepatocellular Carcinoma Cells
Appl Biochem Biotechnol. 2023 Jun 5. doi: 10.1007/s12010-023-04571-1. Online ahead of print.ABSTRACTThe utilisation of medicinal plants and their essential oils is receiving more attention due to the ineffectiveness of current therapeutic methods in the treatment of various cancers and the rising incidence of bacterial antibiotic resistance. Thymol, an active ingredient of Thymus vulgaris, is known to have hepatoprotective, antibacterial, and antioxidant properties. To overcome major obstacles to their usage, such as quick oxidation and high volatility, plant essential oils must be administered through a system to improve ...
Source: Applied Biochemistry and Biotechnology - June 5, 2023 Category: Biochemistry Authors: Simran Nasra Nikita Meghani Ashutosh Kumar Source Type: research
Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway
In this study, the neuroprotective effect and mechanism of WYP on NTDs were investigated in vivo using an atRA-induced mouse model and in vitro using cell injury model induced by atRA in Chinese hamster ovary (CHO) cells and Chinese hamster dihydrofolate reductase-deficient (CHO/dhFr) cells. Our findings suggest that WYP has an excellent preventive effect on atRA-induced NTDs in mouse embryos, which may be related to the activation of the PI3K/Akt signaling pathway, improved embryonic antioxidant capacity, and anti-apoptotic effects, and this effect is not dependent on folic acid (FA). Our results demonstrated that WYP sig...
Source: International Journal of Developmental Neuroscience - May 22, 2023 Category: Neuroscience Authors: Xinliang Wang Chanjuan Yang Yanrong Li Qiang Gong Yi Ru Liangqi Xie Baoguo Xiao Xiaoming Jin Cungen Ma Zhi Chai Huijie Fan Source Type: research
Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization
CONCLUSIONS: GQBZP can ameliorate Ara-C-induced IM by reducing macrophage polarization to M1, and acridine and senkyunolide A are representative active compounds in GQBZP that target JAK2 to inhibit M1 polarization. Targeting JAK2 to regulate M1 polarization may be a valuable therapeutic strategy for IM.PMID:37209628 | DOI:10.1016/j.biopha.2023.114902
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 20, 2023 Category: Drugs & Pharmacology Authors: Wei Chu Ya-Ling Li Jun-Jie Li Jia Lin Mi Li Jiao Wang Jian-Zheng He Yue-Mei Zhang Juan Yao Xiao-Jie Jin Hui Cai Yong-Qi Liu Source Type: research
Molecular mechanism of ferulic acid and its derivatives in tumor progression
Pharmacol Rep. 2023 May 18. doi: 10.1007/s43440-023-00494-0. Online ahead of print.ABSTRACTCancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery, radiotherapy, chemotherapy, and new therapeutic methods such as targeted therapy and immunotherapy, which have been developed rapidly in recent years. Recently, the tumor antitumor effects of the active ingredients of natural plants have attracted extensive attention. Ferulic acid (FA), (3-methoxy-4-hydroxyl cinnamic), with the molecular formula is C10H10O4, is a phenolic organic compound fou...
Source: Pharmacological Reports - May 18, 2023 Category: Drugs & Pharmacology Authors: Xingxun Bao Wei Li Ruixue Jia Dandan Meng Hairong Zhang Lei Xia Source Type: research
Purification of Polysaccharides from Orostachys cartilaginous Cell Cultures by Macroporous Resin Absorption and Bioactivities of the Purified Polysaccharides
Chem Biodivers. 2022 Nov 3. doi: 10.1002/cbdv.202200452. Online ahead of print.ABSTRACTOrostachys cartilaginous is a traditional herbal medicine and its cell cultures contain large amounts of polysaccharides. To utilize the cultured O. cartilaginous cells, this study purified the crude polysaccharides of O. cartilaginous cells by macroporous resin absorption and optimized the purification process in the experiment of orthogonal design with four factors (sample concentration and volume, and eluent concentration and volume) and three levels; the antibacterial and anti-cancer effects of the purified polysaccharides (OTP) were...
Source: Chemistry and Biodiversity - November 3, 2022 Category: Biochemistry Authors: Ya-Nan Xu Xiao-Li An Lu Han Xuan-Chun Piao Yue-Jun Hao Wan Meng Meilan Lian Source Type: research
