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Total 213 results found since Jan 2013.
Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway
Ecotoxicol Environ Saf. 2023 Sep 14;264:115478. doi: 10.1016/j.ecoenv.2023.115478. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is considered the most toxic carcinogenic compound, and exposure to AFB1 is highly associated with hepatocellular carcinoma. The aim of this study was to investigate the effects of different doses of AFB1 on growth performance and the liver of rabbits, as well as explore its underlying mechanisms. A total of eighty 30-day-old meat rabbits were randomly divided into four treatments. The control group was fed a pollution-free diet, while the AFL, AFM, and AFH groups were fed contaminated diets ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Lu Zhang Shaowen Shi Ying Liu Yuqing Cui Yixuan Zhu Yongzhan Bao Baojiang Chen Wanyu Shi Source Type: research
Comprehensive assessment of detoxification mechanisms of hydrolysis fish peptides in largemouth bass (Micropterus salmoides) under copper exposure: Tracing from bioaccumulation, oxidative stress, lipid deposition to metabolomics
In conclusion, our study confirmed that HFP supplementation was closely associated with oxidative stress, enzymatic activities and related pathways of lipid metabolism, and apoptosis, and in general alleviated lipid deposition caused by copper exposure in largemouth bass.PMID:37651792 | DOI:10.1016/j.ecoenv.2023.115418
Source: Ecotoxicology and Environmental Safety - August 31, 2023 Category: Environmental Health Authors: Di Wu Liansheng Wang Ze Fan Jinnan Li Shizhan Tang Chen Zhao Haitao Zhang Xianhu Zheng Source Type: research
Potential mechanisms of different methylation degrees of pectin driving intestinal microbiota and their metabolites to modulate intestinal health of Micropterus salmoides
Int J Biol Macromol. 2023 Aug 15:126297. doi: 10.1016/j.ijbiomac.2023.126297. Online ahead of print.ABSTRACTFour diets containing 8 % cellulose, low methyl-esterified pectin (LMP), high methyl-esterified pectin (HMP) and MMP (half LMP and half HMP) were designed to evaluate the potential mechanisms by which different esterification degrees of pectin drive intestinal microbiota and their metabolites modulating the intestinal health of Micropterus salmoides. The results showed that both dietary LMP and HMP consistently upregulated intestinal zonula occludens protein 1 (Zo-1), Caludin-1, and Caludin-4, and downregulated intes...
Source: International Journal of Biological Macromolecules - August 17, 2023 Category: Biochemistry Authors: Yu Liu Hang Zhou Jiongting Fan Huajing Huang Junming Deng Beiping Tan Source Type: research
Zinc Supplementation Reduces Testicular Cell Apoptosis in Mice and Improves Spermatogenic Dysfunction Caused by Marginal Zinc Deficiency
Biol Trace Elem Res. 2023 Jul 29. doi: 10.1007/s12011-023-03789-8. Online ahead of print.ABSTRACTZinc (Zn) is an important trace element in the human body and plays an important role in growth, development, and male reproductive functions. Marginal zinc deficiency (MZD) is common in the human population and can cause spermatogenic dysfunction in males. Therefore, the aim of this study was to investigate methods to improve spermatogenic dysfunction caused by MZD and to further explore its mechanism of action. A total of 75 4-week-old male SPF ICR mice were randomly divided into five groups (control, MZD, MZD + ZnY2, MZD + Z...
Source: Biological Trace Element Research - July 29, 2023 Category: Biology Authors: Xiangchao Zeng Ziqiong Wang Lu Yu Lei Wang Yueling Liu Yuxin Chen Chunhong Wang Source Type: research
Experiences of and preferences for self-management among low grade non-Hodgkin's lymphoma survivors: A qualitative interview study
CONCLUSIONS: Providing self-management support to those diagnosed with low grade non-Hodgkin's lymphoma is relevant given the chronic trajectory of the disease. Findings suggest that necessary components of a self-management support programme for those with low grade non-Hodgkin's lymphoma should include regular review with monitoring and practical support around facilitating engagement with social networks.PMID:37506608 | DOI:10.1016/j.ejon.2023.102378
Source: European Journal of Oncology Nursing - July 28, 2023 Category: Nursing Authors: Nickola D Pallin Mairead O'Connor Alannah Gannon John Browne Mary R Cahill Derville O'Shea Source Type: research
A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer
CONCLUSIONS: Mg is essential for optimal immune function and regulating inflammation. Deficiency in Mg can lead to temporary or long-term immune dysfunction. A balanced diet usually provides sufficient Mg, but supplementation may be necessary in some cases. Excessive supplementation can have negative impacts on immune function and should be avoided. This review provides an update on the importance of Mg in an immune response against cancer cells and infectious agents and how it regulates inflammation, oxidative stress, cell progression, differentiation, and apoptosis.PMID:37501216 | DOI:10.1186/s41043-023-00423-0
Source: Journal of Health, Population, and Nutrition - July 27, 2023 Category: International Medicine & Public Health Authors: Sumel Ashique Shubneesh Kumar Afzal Hussain Neeraj Mishra Ashish Garg B H Jaswanth Gowda Arshad Farid Gaurav Gupta Kamal Dua Farzad Taghizadeh-Hesary Source Type: research
Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism
Anim Biotechnol. 2023 Jul 6:1-12. doi: 10.1080/10495398.2023.2228842. Online ahead of print.ABSTRACTThe experiment investigated the impacts of FA on the proliferation of bovine mammary gland epithelial cells (BMECs) and to investigate the underlying mechanisms. Supplementation of 10 µM FA elevated the mRNA expression of proliferating cell nuclear antigen (PCNA), cyclin A2 and cyclin D1, and protein expression of PCNA and Cyclin A1. The mRNA and protein expression of B-cell lymphoma-2 (BCL2) and the BCL2 to BCL2 associated X 4 (BAX4) ratio elevated, while that of BAX, Caspase-3 and Caspase-9 reduced by FA. Both Akt and mTO...
Source: Animal Biotechnology - July 6, 2023 Category: Biotechnology Authors: Jing Zhang Ya-Peng Liu Li-Jun Bu Qiang Liu Cai-Xia Pei Wen-Jie Huo Source Type: research
