• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Results of Novel Clinical Study of Guselkumab and Golimumab Combination Therapy Show Adults with Moderately to Severely Active Ulcerative Colitis Maintained Higher Rates of Clinical, Histologic, and Endoscopic Remission at Week 38
SPRING HOUSE, PENNSYLVANIA, October 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from an ongoing analysis of a Phase 2a clinical trial showing adults with moderately to severely active ulcerative colitis (UC) who received 12 weeks of combination induction therapy with guselkumab and golimumab, followed by a transition to guselkumab alone for maintenance, achieved a clinical remission ratea (based on the modified Mayo score [mMayo])b at week 38 of 47.9 percent, a higher rate than induction and maintenance treatment with either guselkumab alone (31.0 percent) or golimumab al...
Source: Johnson and Johnson - October 10, 2022 Category: Pharmaceuticals Source Type: news

What Do Hospitalists Need to Know About Monkeypox?
What is monkeypox? Monkeypox is a rare infection caused by the monkeypox virus. Monkeypox virus belongs to the Orthopoxvirus genus in the family Poxviridae. The Orthopoxvirus genus also includes variola virus (which causes smallpox), vaccinia virus (used in the smallpox vaccine), and cowpox virus.1 It was first isolated in 1958 and identified as causing human disease in 1970. This pathogen was endemic in central and western African countries up until recently. Between 2018 to May 2022, about nine cases of monkeypox were confirmed in a few non-endemic countries.2 There are two strains of monkeypox: West African monkeypox ...
Source: The Hospitalist - June 24, 2022 Category: Hospital Management Authors: Daniel Hickman Tags: Clinical Guidelines Diagnostic Emerging Infections Infectious Diseases Source Type: research

What Causes Free Peritoneal Fluid?
Discussion Peritoneal fluid is normal. It decreases the friction of the peritoneum covering abdominal and pelvic organs and helps to protect them and allow their movement. A normal amount of peritoneal fluid is expected on radiological evaluation. Increased peritoneal fluid is a continuum and is concerning as a wide variety of pathological causes are associated with it such as abdominal trauma and appendicitis. At the far end of the scale is ascites that is the accumulation of free fluid more than 25 ml. It is usually associated with abdominal distension but fluid must accumulate before distension can occur and therefore i...
Source: PediatricEducation.org - June 8, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Cytomegalovirus pneumonia in a patient with T-lymphoblastic leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: A case report
Rationale: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for hematological malignancies. Common complications are opportunistic infections and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) is one of the most common causes of opportunistic infections. Patient concerns: A 30-year-old male was diagnosed with T-cell lymphoma after persistent cough and lymphadenopathy. Fever, abdominal pain, diarrhea, rash, and dyspnea occurred after HSCT. Diagnosis: The young man developed severe CMV infection with CMV detected in the bronchoalveolar lavage fluid and gastrointestinal...
Source: Medicine - January 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Extensive colonic pneumatosis in a patient on adjuvant chemotherapy after right colectomy for primary terminal ileum lymphoma: A decision-making process between surgical and non-surgical management
ConclusionIn analogous cases, the main dilemma for the physicians is to identify whether surgical intervention is required or not. Given the potential severity of pneumatosis intestinalis, early diagnosis and recognition of its severity is critical as it would dictate surgical or non-surgical management.
Source: International Journal of Surgery Case Reports - October 9, 2018 Category: Surgery Source Type: research

Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs

What Conditions is Erythema Nodosum Associated With?
Discussion Erythema nodosum (EN) is a common dermatological eruption characterized by inflammatory nodules of the subcutaneous fat (panniculitis) on the extensor surfaces of the extremities especially the shins, thighs, and forearms. They are usually painful, nodular, bilateral and multiple. They can be found on other areas and be unilateral. They can be red, purple or blackish. They usually resolve without problems in 3-6 weeks. Diagnosis is usually clinical but biopsy may be needed if there is atypical presentation or history, physical examination or laboratory testing reveals potential underlying diseases. Treatment is...
Source: PediatricEducation.org - July 24, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Volume: 25 Issue: 4
This study aimed to assess the safety and efficacy of two such vaccines, one against one serogroup (serogroup C) and the other a quadrivalent vaccine targeting four serogroups (A, C, Y and W). Evaluation of amplification targets for the specific detection of <em>Bordetella pertussis</em> using real-time polymerase chain reaction<span style="font-style: italic">Bordatella pertussis</span>, the causative organism leading to whooping cough, represents a considerable public health concern in Canada. However, the current method of detection of <span style="font-style: italic">B ...
Source: Canadian Journal of Infectious Diseases and Medical Microbiology - December 23, 2015 Category: Infectious Diseases Source Type: research

Intussusception By The Numbers
Discussion Intussusception occurs when one segment of the gastrointestinal tract telescopes into an adjacent segment. The outer receiving segment of bowel is known as the intussuscipiens and the inner inverting segment is known as the intussusceptum. It occurs most often in children between 2 months to 5 years, with a peak incidence between 4-10 months. Males are more often affected than females by 3:2. It also occurs more often after abdominal operations particularly in the first 2 weeks. It is the second most common acute abdominal emergency in children after appendicitis. In adults ~80% have an underlying cause or lead ...
Source: PediatricEducation.org - September 7, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Outcomes in Myelofibrosis Patients Completing 24 and 36 Weeks of Treatment with PRM-151
PRM-151 demonstrated IWG-MRT symptom improvement and/or bone marrow (BM) fibrosis reduction in 43% of 26 patients with Primary Myelofibrosis (MF), post-PV MF, or post-ET MF and ≥ Grade 2 BM fibrosis [PRM-151 10 mg/kg IV QW (n=7) or Q4W (n=7), or ruxolitinib plus PRM-151 10 mg/kg IV QW (n=6) or Q4W (n=6)]. Most AEs were Grade 1 or 2 with 5 possibly/probably related SAEs (gastroenteritis, pneumonia (2), abdominal pain, sialadenitis) [Verstovsek ASH 2014]). This analysis reports efficacy outcomes for patients who completed 24 and 36 weeks.
Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2015 Category: Hematology Authors: Srdan Verstovsek, Olga Pozdnyakova, Robert Hasserjian, Mohamed Salama, Ruben Mesa, Lynda Foltz, Vikas Gupta, John Mascarenhas, Ellen Ritchie, Ronald Hoffman, Richard Silver, Marina Kremyanskaya, Elizabeth Trehu, Hagop Kantarjian, Jason Gotlib Tags: Abstract Source Type: research

Primary multifocal lymphoma of peripheral nervous system: Case report and review of the literature
Conclusions: Primary lymphoma of peripheral nerves (PLPNs) is a rare but potentially treatable condition, which is frequently misdiagnosed. In the literature, there are very few descriptions of PLPNs, mostly mononeuropathies. The possibility of a neuropathy associated with lymphoma should be considered in patients with poor response to treatment and severe pain symptoms. © 2014 Wiley Periodicals, Inc.
Source: Muscle and Nerve - August 1, 2014 Category: Internal Medicine Authors: Alessandra Del Grande, Mario Sabatelli, Marco Luigetti, Amelia Conte, Giuseppe Granata, Vittoria Rufini, Annemilia Del Ciello, Simona Gaudino, Eduardo Fernandez, Stefan Hohaus, Antonella Coli, Libero Lauriola Tags: Case of the Month Source Type: research

An unusual cause of ascites in a young patient.
In conclusion, clinicians should have suspicion of eosinophilic gastroenteritis when forming a differential diagnosis regarding gastrointestinal symptoms. Definite diagnosis is made by histopathological assessment. Treatment with steroids is the mainstay in the management of eosinophilic gastroenteritis. Clinical improvement is usually seen after treatment with a low dose of steroid. PMID: 23794354 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - February 1, 2013 Category: Gastroenterology Authors: Taş A Tags: Turk J Gastroenterol Source Type: research