Filtered By:
Cancer: Lymphoma
Education: Study

This page shows you your search results in order of date. This is page number 2.

Order by Relevance | Date

Total 296 results found since Jan 2013.

Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma
J Immunol Res. 2022 Aug 9;2022:9544827. doi: 10.1155/2022/9544827. eCollection 2022.ABSTRACTDiffuse large B cell lymphoma (DLBCL) is one of the most usual types of adult lymphoma with heterogeneousness in histological morphology, prognosis, and clinical indications. Prior to this, several studies were carried out to determine the DLBCL subtype based on the analysis of the genome profile. However, classification based on assessment of genes related to the immune system has limited clinical significance for DLBCL. We systematically explored the DLBCL gene expression dataset and provided publicly available clinical informatio...
Source: Journal of Immunology Research - August 19, 2022 Category: Allergy & Immunology Authors: Longhao Wang Wei Yuan Lifeng Li Zhibo Shen Qishun Geng Yuanyuan Zheng Jie Zhao Source Type: research

iRGD-modified exosomes-delivered BCL6 siRNA inhibit the progression of diffuse large B-cell lymphoma
Clinical applications of siRNA therapeutics have been limited by the immunogenicity of the siRNA and low efficiency of siRNA delivery to target cells. Recently, evidence have shown that exosomes, endogenous nano-vesicles, can deliver siRNA to the tumor tissues in mice. Here, to reduce immunogenicity, we selected immature dendritic cells (DCs) to produce exosomes. In addition, tumor targeting was achieved by engineering the DCs to express exosomal membrane protein (Lamp2b), fused to av integrin-specific iRGD peptide (CRGDKGPDC). Next, iRGD targeted exosomes (iRGD-Exo) were isolated from the transfected DCs, and then the iso...
Source: Frontiers in Oncology - August 2, 2022 Category: Cancer & Oncology Source Type: research

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
Biochem J. 2022 May 18:BCJ20210770. doi: 10.1042/BCJ20210770. Online ahead of print.ABSTRACTUridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively. Only two human UCKs have been identified, UCK1 and UCK2. Previous studies have shown both enzymes phosphorylate uridine and cytidine using ATP as the phosphate donor. No studies have evaluated the kinase potential of UCKL-1. We cloned and pu...
Source: The Biochemical Journal - May 18, 2022 Category: Biochemistry Authors: Emily Matchett Elise C Ambrose Jacki Kornbluth Source Type: research

Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling
Phytother Res. 2022 May 18. doi: 10.1002/ptr.7481. Online ahead of print.ABSTRACTPsoralidin (PSO) is a natural phenolic coumarin extracted from the seeds of Psoralea corylifolia L. Growing preclinical evidence indicates that PSO has anti-inflammatory, anti-vitiligo, anti-bacterial, and anti-viral effects. Growth arrest-specific gene 6 (GAS6) and its receptor, Axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. Notably, the neuroprotective role of the GAS6/Axl axis has been identified in previous studies. We hypothesize that PSO ameliorates cerebral hypoxia/reoxygenation ...
Source: Cell Research - May 18, 2022 Category: Cytology Authors: Wangrui Lei Songdi Wu Aizhen Zhao Zhen Wu Baoping Ding Wenwen Yang Chenxi Lu Xue Wu Xiyang Li Shaofei Zhang Ye Tian Yang Yang Source Type: research

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
Biochem J. 2022 May 18:BCJ20210770. doi: 10.1042/BCJ20210770. Online ahead of print.ABSTRACTUridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively. Only two human UCKs have been identified, UCK1 and UCK2. Previous studies have shown both enzymes phosphorylate uridine and cytidine using ATP as the phosphate donor. No studies have evaluated the kinase potential of UCKL-1. We cloned and pu...
Source: The Biochemical Journal - May 18, 2022 Category: Biochemistry Authors: Emily Matchett Elise C Ambrose Jacki Kornbluth Source Type: research

A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing
CONCLUSION: Our findings demonstrate that circHNRNPU_603aa is a promising diagnostic and therapeutic marker in both MM cells and BM niche.PMID:35260179 | DOI:10.1186/s13046-022-02276-7
Source: Clinical Lymphoma and Myeloma - March 9, 2022 Category: Cancer & Oncology Authors: Xiaozhu Tang Zhendong Deng Pinggang Ding Wanting Qiang Yue Lu Shengyao Gao Ye Hu Ye Yang Juan Du Chunyan Gu Source Type: research

SAMHD1 Mutations and Expression in Mantle Cell Lymphoma Patients
SAMHD1 (sterile alpha motif domain and histidine-aspartate domain-containing protein 1) is a deoxynucleoside triphosphate triphosphohydrolase regulating innate immune and modulating DNA damage signaling. It plays an important role in the development of some tumors. SAMHD1 was also reported as a barrier to cytarabine, a common chemotherapy drug for mantle cell lymphoma (MCL), and as a biomarker of grim prognosis for acute myelocytic leukemia (AML) patients. However, SAMHD1 expression and function in MCL have not been well-defined. In the present study, we evaluated SAMHD1 expression by immunohistochemistry and its gene stru...
Source: Frontiers in Oncology - December 17, 2021 Category: Cancer & Oncology Source Type: research

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light–Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro
Purpose: Blue light triggers apoptosis of retinal pigment epithelium (RPE) cells and causes retinal damage. The aim of this study was to elucidate the protective role of transient receptor potential melastatin 7 (TRPM7) in photodamaged RPE cells. Methods: RPE cells were isolated from Sprague-Dawley (SD) rats and exposed to varying intensities of blue light (500–5000 lux) in vitro. Cell proliferation and metabolic activity were respectively assessed by bromodeoxyuridine (BrdU) incorporation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays. Real-time polymerase chain reaction (RT...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2021 Category: Opthalmology Tags: Original Study Source Type: research