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Condition: Autoimmune Disease
Cancer: Lymphoma
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Total 550 results found since Jan 2013.
Design, synthesis and bioactivity evaluation of selenium-containing PI3K δ inhibitors
In conclusion, the Se-containing compound Se15 bearing pyrido[3,2-d]pyrimidine scaffold is a novel potent and selective PI3Kδ inhibitor. The introduction of selenium can enrich the structure of PI3Kδ inhibitors and provide a new idea for design of novel PI3Kδ inhibitors.PMID:37672953 | DOI:10.1016/j.bioorg.2023.106815
Source: Bioorganic Chemistry - September 6, 2023 Category: Chemistry Authors: Li Gao Hongyan Chuai Mengyan Ma San-Qi Zhang Jiye Zhang Jiyu Li Yang Wang Minhang Xin Source Type: research
Chemical Probes for Profiling of MALT1 Protease Activity
Chembiochem. 2023 Aug 22:e202300444. doi: 10.1002/cbic.202300444. Online ahead of print.ABSTRACTThe paracaspase MALT1 is a key regulator of the human immune response. It is implicated in a variety of human diseases. For example, deregulated protease activity drives the survival of malignant lymphomas and is involved in the pathophysiology of autoimmune/inflammatory diseases. Thus, MALT1 has attracted attention as promising drug target. While many MALT1 inhibitors have been identified, molecular tools to study MALT1 activity, target engagement and inhibition in complex biological samples, such as living cells and patient ma...
Source: Chembiochem - August 22, 2023 Category: Biochemistry Authors: Steven H L Verhelst Michaela Prothiwa Source Type: research
CD19-targeted chimeric antigen receptor T-cell therapy in patients with concurrent B-cell Non-Hodgkin lymphoma and rheumatic autoimmune diseases: a propensity score matching study
In conclusion, the safety and efficacy of CAR T-cell therapy were not affected in patients with rheumatic autoimmune diseases. Moreover, they achieved better biochemical control of underlying rheumatic diseases.PMID:37604871 | DOI:10.1038/s41409-023-02086-1
Source: Cancer Control - August 21, 2023 Category: Cancer & Oncology Authors: Jiasheng Wang Akram Alkrekshi Srilatha Dasari Hsin-Ti Cindy Lin Dina Elantably Abdul Rahman Al Armashi Source Type: research
Usefulness and Limitations of Current Diagnostic Strategies for Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: Lessons Learned From a Large Cohort
CONCLUSIONS.—: Our study offers a practical evaluation of common diagnostic tests in pulmonary MALT lymphoma. We offer recommendations for a diagnostic workup that takes into consideration the usefulness and the specific limitations of the various diagnostic strategies.PMID:37594899 | DOI:10.5858/arpa.2022-0521-OA
Source: Archives of Pathology and Laboratory Medicine - August 18, 2023 Category: Laboratory Medicine Authors: Christoph Fraune Henry D Tazelaar Yasmeen M Butt Maxwell L Smith Brandon T Larsen Katalin Kelemen Source Type: research
Systematic Review - Type B insulin Resistance with Isolated Hypoglycemia and Supressed Insulin
CONCLUSIONS: Isolated hypoglycemia with low insulin forms a rare subgroup of type B insulin resistance. These patients lack the common characteristics of hyperinsulinemic hypoglycemia and hyperglycemia/insulin resistance. Furthermore, whilst coexisting autoimmune disease is commonly observed, there is potentially an association with aggressive lymphoma, the onset of which may be delayed.PMID:37552775 | DOI:10.1210/clinem/dgad467
Source: The Journal of Clinical Endocrinology and Metabolism - August 8, 2023 Category: Endocrinology Authors: Natasha Brown Marianne S Elston Source Type: research
Low-grade B cell lymphoma in the perirenal space of the left kidney associated with high titer cold agglutinin disease
Am J Blood Res. 2023 Jun 15;13(3):104-109. eCollection 2023.ABSTRACTCold agglutinin disease (CAD) is a subgroup of autoimmune hemolytic anemia caused by monoclonal cold agglutinins produced by clonally expanded B lymphocytes. In primary CAD, lymphoproliferative bone marrow disorder is noted, while as one of the secondary cold agglutinin syndromes (CAS), the initial manifestation of CAD is followed by development of lymphoma. Here, we report a case of low-grade B cell lymphoma developed 3 months after an initial CAD diagnosis. The patient had an extremely high serum cold agglutinin titer (1:16,384) and slightly elevated ser...
Source: Cell Research - July 17, 2023 Category: Cytology Authors: Takashi Miyoshi Tomoya Masada Fumihiko Kono Shinsaku Imashuku Source Type: research
Plasmablastic Lymphoma: Past, Present, and Future
Clin Lymphoma Myeloma Leuk. 2023 Jun 14:S2152-2650(23)00181-7. doi: 10.1016/j.clml.2023.05.014. Online ahead of print.ABSTRACTPlasmablastic Lymphoma is a rare large B-cell lymphoma with unique immunohistochemical and morphological features. It was most commonly associated with HIV infection; however, it's now seen in other immunosuppressed states like autoimmune conditions, post-transplant settings, and even in elderly immunocompetent individuals. Although rare, it is an aggressive lymphoma with unfavorable outcomes. The aim of this manuscript is to have an in-depth review of the current knowledge of epidemiology, pathophy...
Source: Clinical Lymphoma and Myeloma - July 15, 2023 Category: Cancer & Oncology Authors: Supreet Kaur Sudarsan Kollimuttathuillam Source Type: research
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway
In conclusion, CT2-3 induces cell cycle arrest and apoptosis in RA-FLSs through modulating PI3K/AKT pathway, which may serve as a potential lead compound for further novel small molecule anti-RA drug development.PMID:37406849 | DOI:10.1016/j.ejphar.2023.175871
Source: European Journal of Pharmacology - July 5, 2023 Category: Drugs & Pharmacology Authors: Jian Chen Xian Lin Kangdi Liu Juan He Xin Li Chuchu Zhang Yongxing Deng Lianxiang Luo Cheng Tao Qingwen Wang Source Type: research
