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Total 61 results found since Jan 2013.
Inhibition of multiple uptake transporters in cardiomyocytes/mitochondria alleviates doxorubicin-induced cardiotoxicity
In conclusion, our study clarified the role of multiple transporters, especially OCTN2, in DOX uptake in cardiomyocytes/mitochondria; metformin alleviated DOX-induced cardiotoxicity without compromising its antitumor efficacy by selective inhibition of multiple transporters mediated DOX accumulation in myocardium/mitochondria.PMID:37453608 | DOI:10.1016/j.cbi.2023.110627
Source: Chemico-Biological Interactions - July 15, 2023 Category: Molecular Biology Authors: Yaodong Yi Hengbin Zhang Mingyang Chen Binxin Chen Yingchun Chen Ping Li Hui Zhou Zhiyuan Ma Huidi Jiang Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP.
Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes
https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/
Researchers here make a few interesting observations on gene expression data from a range of mammalian species with ...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microarray analysis of mRNA expression profiles in liver of ob/ob mice with real-time atmospheric PM < sub > 2.5 < /sub > exposure
This study provided valuable clues and possible protective measures to the liver damage in ob/ob mice caused by PM2.5 exposure, and further research is needed to explore the related mechanism in detail.PMID:35672633 | DOI:10.1007/s11356-022-21088-y
Source: Environmental Science and Pollution Research International - June 7, 2022 Category: Environmental Health Authors: Lisen Lin Li Tian Tianyu Li Mengqi Sun Junchao Duan Yang Yu Zhiwei Sun Source Type: research
Reduced Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma in Type 2 Diabetes Mellitus: Will Metformin Never Stop Its Pleasant Surprises?
Adv Ther. 2022 Mar 28. doi: 10.1007/s12325-022-02125-1. Online ahead of print.ABSTRACTMonoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic plasma cell disorder characterised by a serum M protein level below 3 g/dL, percentage of bone marrow clonal plasma cells below 10%, absence of end-organ damage (hypercalcaemia, renal insufficiency, anaemia, bone lesions) and absence of any other disease known to produce M protein. MGUS may progress to myeloproliferative disorders or multiple myeloma, but very little is known about any modifiable risk factors or any preventative treatment that might delay this pr...
Source: Adv Data - March 28, 2022 Category: Epidemiology Authors: Stella Papachristou Djordje S Popovic Nikolaos Papanas Source Type: research
