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Post-transplant food anaphylaxis in an adult cord blood transplant recipient (Ms. No. IJHM-D-20-01037R1)
Int J Hematol. 2021 Mar 27. doi: 10.1007/s12185-021-03140-8. Online ahead of print.ABSTRACTTransplant acquired food allergy (TAFA) is a well-known complication following pediatric liver transplantation, but post-cord blood transplantation (post-CBT) TAFA has rarely been reported. Here, we describe a case of new-onset food anaphylaxis after CBT in an adult patient that demonstrates that post-CBT allergen-challenge is not a risk for long-term allergic sensitization even in adult recipients. The patient was a 39-year-old Japanese man with aggressive NK cell leukemia. He had no previous history of allergies. After receiving CB...
Source: International Journal of Hematology - March 27, 2021 Category: Hematology Authors: Ai Kawahara Tsukasa Nakanishi Midori Goto Kenichi Akao Takefumi Katsuragi Junichi Tsukada Source Type: research

Inhibitory effects of cyanidin-3-O-glucoside in black soybean hull extract on RBL-2H3 cells degranulation and passive cutaneous anaphylaxis reaction in mice.
This study provides evidence for the potential use of BSHE and C3G for the prevention or the treatment of type I allergies. PMID: 33582590 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Hiemori-Kondo M, Morikawa E, Fujikura M, Nagayasu A, Maekawa Y Tags: Int Immunopharmacol Source Type: research

Molecules, Vol. 24, Pages 2131: Hispidulin Inhibits Mast Cell-Mediated Allergic Inflammation through Down-Regulation of Histamine Release and Inflammatory Cytokines
im Kwon Hispidulin (4′,5,7-trihydroxy-6-methoxyflavone) is a natural compound derived from traditional Chinese medicinal herbs, and it is known to have an anti-inflammatory effect. Here, we investigated the effect of hispidulin on the immunoglobulin E (IgE)-mediated allergic responses in rat basophilic leukemia (RBL)-2H3 mast cells. When RBL-2H3 cells were sensitized with anti-dinitrophenyl (anti-DNP) IgE and subsequently stimulated with DNP-human serum albumin (HSA), histamine and β-hexosaminidase were released from the cells by degranulation of activated mast cells. However, pretreatment...
Source: Molecules - June 4, 2019 Category: Chemistry Authors: Kim Min Kim Kim Kwon Tags: Article Source Type: research

Covalent Heterobivalent Inhibitor Design for Inhibition of IgE-Dependent Penicillin Allergy in a Murine Model.
Abstract Drug allergies occur when hapten-like drug metabolites conjugated to serum proteins, through their interactions with specific IgE, trigger allergic reactions that can be life threatening. A molecule termed covalent heterobivalent inhibitor (cHBI) was designed to specifically target drug hapten-specific IgE to prevent it from binding drug-haptenated serum proteins. cHBI binds the two independent sites on a drug hapten-specific Ab and covalently conjugates only to the specific IgE, permanently inhibiting it. The cHBI design was evaluated via ELISA to measure cHBI-IgE binding, degranulation assays of rat bas...
Source: Journal of Immunology - May 16, 2019 Category: Allergy & Immunology Authors: Deak PE, Kim B, Koh B, Qayum AA, Kiziltepe T, Kaplan MH, Bilgicer B Tags: J Immunol Source Type: research

Development of a rice-based peptide vaccine for Japanese cedar and cypress pollen allergies.
Abstract Peptide immunotherapy using dominant T-cell epitopes is a safe treatment alternative to conventional subcutaneous injection of natural crude allergen extract, which is sometimes accompanied by anaphylactic shock. For Japanese cedar pollinosis (JCP), hybrid peptides composed of six to seven major T-cell epitopes (7Crp peptide) from the causative allergens Cry j 1 and Cry j 2 have been developed on the basis of different human leukemia antigen class II restrictions, because of the diversity of patients' genetic backgrounds. However, other dominant T-cell epitopes that are produced in some patients are not c...
Source: Transgenic Research - March 18, 2014 Category: Genetics & Stem Cells Authors: Takaiwa F, Yang L Tags: Transgenic Res Source Type: research