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Cancer: Colorectal Cancer
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Total 855 results found since Jan 2013.
Natural products and mitochondrial allies in colorectal cancer therapy
Biomed Pharmacother. 2023 Sep 13;167:115473. doi: 10.1016/j.biopha.2023.115473. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a globally prevalent malignancy with a high potential for metastasis. Existing cancer treatments have limitations, including drug resistance and adverse effects. Researchers are striving to develop effective therapies to address these challenges. Impressively, contemporary research has discovered that many natural products derived from foods, plants, insects, and marine invertebrates can suppress the progression, metastasis, and invasion of CRC. In this review, we conducted a comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Feng Wei Qing Nian Maoyuan Zhao Yueqiang Wen Yi Yang Jundong Wang Zhelin He Xiaoyan Chen Xiang Yin Jian Wang Xiao Ma Yu Chen Peimin Feng Jinhao Zeng Source Type: research
pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.PMID:37702969 | DOI:10.1002/jbm.b.35320
Source: Biomed Res - September 13, 2023 Category: Research Authors: Xueqiang Sun Fuxin Li Lingyan Yuan Zhitong Bing Xun Li Kehu Yang Source Type: research
AI-2 quorum sensing controlled delivery of cytolysin-A by tryptophan auxotrophic low-endotoxic Salmonella and its anticancer effects in CT26 mice with colon cancer
CONCLUSION: Hence, the anti-tumor effect of the engineered Salmonella strain was improved by ClyA expression via QS activation after achieving the threshold bacterial cell density. Further, immunohistochemical staining of the tumor and other organs corroborated the QS-controlled tumor-specific expression of ClyA. Overall, the results imply that the developed anti-cancer Salmonella has low endotoxicity and QS-controlled expression of ClyA as beneficial safety elements and supports recurrent Salmonella inoculation by O-antigen deficiency.PMID:37689243 | DOI:10.1016/j.jare.2023.09.003
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Ram Prasad Aganja Chandran Sivasankar John Hwa Lee Source Type: research
Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using < em > Perilla frutescens < /em > Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.PMID:37687260 | DOI:10.3390/molecules28176431
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Source Type: research
Autophagy/ferroptosis in colorectal cancer: Carcinogenic view and nanoparticle-mediated cell death regulation
Environ Res. 2023 Sep 3:117006. doi: 10.1016/j.envres.2023.117006. Online ahead of print.ABSTRACTThe cell death mechanisms have a long history of being evaluated in diseases and pathological events. The ability of triggering cell death is considered to be a promising strategy in cancer therapy, but some mechanisms have dual functions in cancer, requiring more elucidation of underlying factors. Colorectal cancer (CRC) is a disease and malignant condition of colon and rectal that causes high mortality and morbidity. The autophagy targeting in CRC is therapeutic importance and this cell death mechanism can interact with apopt...
Source: Environmental Research - September 5, 2023 Category: Environmental Health Authors: Zhibin Zhang Yintao Zhao Yuman Wang Yutang Zhao Jianen Guo Source Type: research
Water-Soluble Alkali Lignin as a Natural Radical Scavenger and Anticancer Alternative
Int J Mol Sci. 2023 Aug 11;24(16):12705. doi: 10.3390/ijms241612705.ABSTRACTSeveral phytochemicals, which display antioxidant activity and inhibit cancer cell phenotypes, could be used for cancer treatment and prevention. Lignin, as a part of plant biomass, is the second most abundant natural biopolymer worldwide, and represents approximately 30% of the total organic carbon content of the biosphere. Historically, lignin-based products have been viewed as waste materials of limited industrial usefulness, but modern technologies highlight the applicability of lignin in a variety of industrial branches, including biomedicine....
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Donika Ivanova Galina Nikolova Yanka Karamalakova Severina Semkova Vania Marutsova Zvezdelina Yaneva Source Type: research
Preparation of an Ultrahigh-DAR PDL1 monoclonal antibody-polymeric-SN38 conjugate for precise colon cancer therapy
Biomaterials. 2023 Aug 17;301:122285. doi: 10.1016/j.biomaterials.2023.122285. Online ahead of print.ABSTRACTAntibody-drug conjugates (ADCs) are the most potent active tumor-targeting agents used clinically. However, the preparation of ADCs with high drug-to-antibody ratios (DARs) remains a major challenge. Herein, a Fab-nondestructive SN38-loaded antibody-polymeric-drug conjugate (APDC), aPDL1-NPLG-SN38, was prepared that had a DAR as high as 72 for the first time, by increased numbers of payload binding sites via the carboxyl groups of poly (l-glutamic acid) (PLG). The bonding of Fc-III-4C peptide with PLG-graft-mPEG/SN3...
Source: Biomaterials - August 24, 2023 Category: Materials Science Authors: Honglei Zhang Jiali Sun Yu Zhang Zhenqian Zhang Xiaoshuang Wang Zhilin Liu Xuefei Zhang Zhaohui Tang Xuesi Chen Source Type: research
Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines
Biochem Pharmacol. 2023 Aug 12:115746. doi: 10.1016/j.bcp.2023.115746. Online ahead of print.ABSTRACTUSP28 contributes to tumorigenesis through modulating the lifespan of oncogenic factors such as c-Myc and ΔNp63, and it has been identified as a potential target for anti-cancer drug development. Currently, although quite a number of USP28 inhibitors have been developed, they all are still in preclinical research stage. Besides, none of them exhibits satisfying inhibition selectivity against USP28 over its closest homologue USP25. Here in this manuscript, a high-throughput screening aiming to discover USP28 inhibitors with...
Source: Biochemical Pharmacology - August 14, 2023 Category: Drugs & Pharmacology Authors: Zhuo Xu Hui Wang Qian Meng Yiluan Ding Mengying Zhu Hu Zhou Naixia Zhang Li Shi Source Type: research
Development of a Multilevel Model to Identify Patients at Risk for Delay in Starting Cancer Treatment
CONCLUSIONS AND RELEVANCE: In this cohort study, a machine learning model incorporating EHR and SDOH data was able to estimate the likelihood of delays in starting cancer therapy. Future work should focus on additional ways to incorporate SDOH data to improve model performance, particularly in vulnerable populations.PMID:37578796 | DOI:10.1001/jamanetworkopen.2023.28712
Source: Cancer Control - August 14, 2023 Category: Cancer & Oncology Authors: Zachary A K Frosch Jill Hasler Elizabeth Handorf Tesla DuBois Richard J Bleicher Martin J Edelman Daniel M Geynisman Michael J Hall Carolyn Y Fang Shannon M Lynch Source Type: research
