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Short-term outcomes of colorectal cancer surgery in patients with dialysis: a systematic review and meta-analysis
CONCLUSION: Our meta-analysis showed that dialysis-dependent CKD was associated with higher rates of mortality, cardiac complications, and pneumonia after colorectal cancer surgery. However, the limitations of this meta-analysis should be taken into consideration when interpreting the results.PMID:37464017 | DOI:10.1007/s00423-023-03016-x
Source: Hand Surgery - July 18, 2023 Category: Surgery Authors: Yasuhiro Takano Wataru Kai Yasunobu Kobayashi Hironori Kanno Nobuyoshi Hanyu Source Type: research

Pharmacologic Effects of Oxaliplatin Instability in Chloride-Containing Carrier Fluids on the  Hyperthermic Intraperitoneal Chemotherapy to Treat Colorectal Cancer In Vitro and In Vivo
CONCLUSIONS: Chloride-containing fluids, such as normal saline or Dianeal, which display high absorption rates of oxaliplatin and acceptable degradation rates, may be more beneficial for use in oxaliplatin-based HIPEC than 5DW.PMID:36042101 | DOI:10.1245/s10434-022-12358-7
Source: Ann Oncol - August 30, 2022 Category: Cancer & Oncology Authors: Eun Jung Park Junhyun Ahn Sharif Md Abuzar Kyung Su Park Sung-Joo Hwang Seung Hyuk Baik Source Type: research

Aptamer-conjugated nanoliposomes containing COL1A1 siRNA sensitize CRC cells to conventional chemotherapeutic drugs
In this study, As1411 aptamer-conjugated liposomes were used for targeted siRNA delivery against the COL1A1 gene in colorectal cancer (CRC) cells. Cationic liposomes were synthesized and siRNA loading and conjugation of aptamer were confirmed by gel shift assay and spectrophotometry method. Release of siRNA from liposomes was assessed using dialysis method. Binding and uptake of aptamer-conjugated liposomes to and into cancer cells was assessed by fluorescence microscopy and flowcytometry. Gene expression was evaluated using qRT-PCR. Cell viability, chemosensitivity and apoptosis were determined by MTT assay and Annexin/PI...
Source: Colloids and Surfaces - July 29, 2022 Category: Biotechnology Authors: Hamed Manoochehri Akram Jalali Hamid Tanzadehpanah Amir Taherkhani Rezvan Najafi Source Type: research

Postoperative outcomes of cancer surgery in patients with and without kidney failure with dialysis therapy: a matched-pair cohort study
CONCLUSIONS: Patients with KFDT had higher rates of postoperative complications and 30-day mortality; however, RDs varied between cancer types. The higher rates of postoperative complications in patients with KFDT were mainly attributable to cardiovascular complications.PMID:35664265 | PMC:PMC9155240 | DOI:10.1093/ckj/sfac005
Source: Clinical Breast Cancer - June 6, 2022 Category: Cancer & Oncology Authors: Yoshihisa Miyamoto Masao Iwagami Shotaro Aso Kazuaki Uda Kiyohide Fushimi Yoshifumi Hamasaki Masaomi Nangaku Hideo Yasunaga Kent Doi Source Type: research

Human Beta Defensins and Cancer: Contradictions and Common Ground
Santosh K. Ghosh1*, Thomas S. McCormick1,2 and Aaron Weinberg1* 1Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States 2Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States Human beta-defensins (hBDs, −1, 2, 3) are a family of epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges. In addition to their antimicrobial activities, they possess other functions; e.g., cell activation, proliferation, regulation of cytokine/chemokine production, migration, dif...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research