Human Beta Defensins and Cancer: Contradictions and Common Ground
Human Beta Defensins and Cancer: Contradictions and Common Ground Santosh K. Ghosh1*, Thomas S. McCormick1,2 and Aaron Weinberg1* 1Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States 2Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States Human beta-defensins (hBDs, −1, 2, 3) are a family of epithelial cell derived antimicrobial peptides (AMPs) that protect mucosal membranes from microbial challenges. In addition to their antimicrobial activities, they possess other functions; e.g., cell activation, proliferation, regulation of cytokine/chemokine production, migration, differentiation, angiogenesis, and wound healing processes. It has also become apparent that defensin levels change with the development of neoplasia. However, inconsistent observations published by various laboratories make it difficult to reach a consensus as to the direction of the dysregulation and role the hBDs may play in various cancers. This is particularly evident in studies focusing on oral squamous cell carcinoma (OSCC). By segregating each hBD by cancer type, interrogating methodologies, and scrutinizing the subject cohorts used in the studies, we have endeavored to identify the “take home message” for each one of the three hBDs. We discovered that (1) consensus-driven findings indicate that hBD-1 and−2 are down- while hBD-3 is up-regulated in OSCC; (2) hBD dysregulatio...
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/D0CP01792B, PaperYifan Zhang, Timing Fang, Quangang Hou, Zhen Li, Youguo Yan Preparing nanoporous membranes with high density and ordered pore sizes which allows high water permeability and salt rejection rate is the key to realize highly efficient desalination. However, Preparing nanoporous... The content of this RSS Feed (c) The Royal Society of Chemistry
Lab Chip, 2020, Accepted Manuscript DOI: 10.1039/D0LC00361A, PaperZhixing Ge, Junhua Zhao, Haibo Yu, Wenguang Yang, Peilin Zhou, Zhenning Wang, Lianqing Liu Currently, the mechanisms underlying the peritoneal metastasis of gastric cancer cells and the function of mesothelial cells during this process are unclear, primarily due to the absence of an effective... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC03614E, CommunicationWentao Zhang, Hyunjun Choi, Bo Yu, Dong-Hyun Kim Iron oxide nanocube patched Janus magnetic porous silica nanocarriers are synthesized and it is expected to be used for a new type of multifunctional carriers in image guided cancer therapeutic applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Publication date: Available online 5 July 2020Source: Genes &DiseasesAuthor(s): Xi Liu, Jimin Xu, Jia Zhou, Qiang Shen
CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.
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