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NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Job mobility and health in the Danish workforce.
CONCLUSIONS FREQUENT MOBILITY IN THE LABOUR MARKET INCREASES THE RISK OF CARDIOVASCULAR DISEASE, COMMON MENTAL DISORDERS AND ALCOHOL-RELATED DISORDERS AND THESE DIAGNOSES ALSO SEEM TO INCREASE THE RISK OF SUBSEQUENT MOBILITY. PMID: 27887031 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - November 23, 2016 Category: Global & Universal Authors: Hougaard CØ, Nygaard E, Holm AL, Thielen K, Diderichsen F Tags: Scand J Public Health Source Type: research

Our Sedentary Lifestyles Cost About 5 Million Lives A Year
By Kate Kelland LONDON (Reuters) - A study of one million people has found that physical inactivity costs the global economy $67.5 billion a year in healthcare and productivity losses, but an hour a day of exercise could eliminate most of that. Sedentary lifestyles are linked to increased risks of heart disease, diabetes and cancer, researchers found, but activity - such as brisk walking - could counter the higher likelihood of early death linked with sitting for eight or more hours a day. Such inactivity is estimated to cause more than 5 million deaths a year - almost as many as smoking, which the World Health Organi...
Source: Healthy Living - The Huffington Post - July 28, 2016 Category: Consumer Health News Source Type: news

The global impact of non-communicable diseases on macro-economic productivity: a systematic review
Abstract Non-communicable diseases (NCDs) have large economic impact at multiple levels. To systematically review the literature investigating the economic impact of NCDs [including coronary heart disease (CHD), stroke, type 2 diabetes mellitus (DM), cancer (lung, colon, cervical and breast), chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD)] on macro-economic productivity. Systematic search, up to November 6th 2014, of medical databases (Medline, Embase and Google Scholar) without language restrictions. To identify additional publications, we searched the reference lists of retriev...
Source: European Journal of Epidemiology - April 3, 2015 Category: Epidemiology Source Type: research