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Activation of the TLR4-JNK but not the TLR4-ERK pathway induced by indole-3-acetic acid exerts anti-proliferative effects on Caco-2 cells
Biosci Biotechnol Biochem. 2023 May 5:zbad055. doi: 10.1093/bbb/zbad055. Online ahead of print.ABSTRACTWe previously found that indole-3-acetic acid (IAA) produced from tryptophan by gut microbiota decreases the expression of tumor necrosis factor alpha (TNFα), which is implicated in the pathogenesis of colorectal cancer (CRC). The present study aimed to determine IAA involvement in the proliferation of CRC-derived Caco-2 cells. Cell proliferation was suppressed by IAA, whereas IAA-induced aryl hydrocarbon receptor (AhR) activation had no impact. IAA activated extracellular signal-related (ERK) and c-Jun N-terminal (JNK) ...
Source: Bioscience, Biotechnology, and Biochemistry - May 5, 2023 Category: Biochemistry Authors: Ayame Tomii Manami Higa Kazuma Naito Koichi Kurata Jun Kobayashi Chihiro Takei Kana Yuasa Yoshihito Koto Hidehisa Shimizu Source Type: research

Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy
Cell Death Dis. 2023 Feb 11;14(2):109. doi: 10.1038/s41419-022-05482-5.ABSTRACTLitchi chinensis seed, as a valuable by-product of the subtropical fruit litchi (Litchi chinensis Sonn.), has been confirmed to be rich in procyanidins (LPC). The anticarcinogenic properties of procyanidins has been primarily attributed to their antioxidant and anti-inflammatory activities. However, there is a comparative paucity of information on if and how LPC inhibits colon cancer. Here, LPC significantly inhibited CT26 colon cancer cells proliferation and metastasis in vivo and in vitro. In CT26 lung metastatic mice, the anti-metastatic effe...
Source: Cancer Control - February 11, 2023 Category: Cancer & Oncology Authors: Yuan Yao Suya Feng Xuejiao Li Taohua Liu Shengying Ye Long Ma Shuli Man Source Type: research

< em > Inula viscosa < /em > phenolic extract suppresses colon cancer cell proliferation and ulcerative colitis by modulating oxidative stress biomarkers
This study aimed to evaluate the in vivo intestinal anti-inflammatory activity of the ethanolic extract of I. viscosa (EEIV) and to test its effect on a colorectal cancer cell line. EEIV was administered to rats orally and daily at 100 and 200 mg/kg body weight for 7 days, and then colitis was induced by intrarectal instillation of 2 ml of 4% (v/v) acetic acid (AA) solution. At the end of the experiment, clinical examinations of the rats were conducted by evaluating macroscopic and histological signs of colonic tissues and measuring erythrocyte sedimentation rate (ESR) and the levels of C-reactive protein, fibrinogen, myel...
Source: Cancer Control - January 6, 2023 Category: Cancer & Oncology Authors: Naoual Kheyar Yuva Bellik Ana Teresa Serra Farida Kheyar Fatiha Bedjou Source Type: research

Synthesis and Anticancer activity of Novel Chromene Derivatives, Chromeno2,3-d1,3oxazines, and Chromeno2,3-dpyrimidines
CONCLUSION: Several chromene derivatives had been synthesized and their structures had been confirmed using different spectroscopic techniques. Some of the chromene derivatives that were screened against different cancer cell lines showed promising anticancer activity higher than the reference standard drug. For example, chromene derivative 2 had anticancer activity against human colon cancer cell lines (HT-29) higher than the reference drug doxorubicin. Chromene derivative 5 had anticancer activity against liver cancer cell lines (HepG-2) higher than the reference drug doxorubicin. Chromene derivative 6 had anticancer act...
Source: Medicinal Chemistry - December 27, 2022 Category: Chemistry Authors: Mahmoud N M Yousif Usama Fathy Nabil M Yousif Source Type: research

Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan. Naked Mole-Rat Skin Shows Fewer Signs of Aging https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/ Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem c...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Polysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites
In this study, our efforts are focused on the influence of LEP on CRC, intestinal barrier and inflammation, and fecal microbiota and the metabolites, in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. Results showed that LEP inhibited CRC mouse colon shortening and weight loss, decreased tumor incidence, restored intestinal barrier integrity, and reduced excessive inflammation. LEP consumption significantly altered microbiota overall structure and community, with reduced pernicious bacteria (such as Parabacteroides, Escherichia_Shigella, Desulfovibrio and Helicobacter), and increased beneficial bacterium ...
Source: International Immunopharmacology - April 7, 2022 Category: Allergy & Immunology Authors: Shuai Zong Hongling Ye Ziyang Ye Yaling He Xinmiao Zhang Ming Ye Source Type: research

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