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The critical role of mast cell ‐derived hypoxia‐inducible factor‐1α in regulating mast cell function
ConclusionsMast cells promote the development of colorectal cancer, and MC‐derived HIF‐1α plays an important role in regulating MC function. Our study reveals a novel role of MC‐derived HIF‐1α in the colorectal carcinoma microenvironment.
Source: Journal of Pharmacy and Pharmacology - September 27, 2016 Category: Drugs & Pharmacology Authors: Xin Liang, Guifang Yin, Yuanyuan Ma, Ke Xu, Jianwen Liu, Jiyu Li Tags: Research Paper Source Type: research

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes
Conclusion Our results indicated that BACH1 down-regulation in HT29 CRC cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression. Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment.
Source: Biomedicine and Pharmacotherapy - September 19, 2016 Category: Drugs & Pharmacology Source Type: research

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
CONCLUSION: Our results indicated that BACH1 down-regulation in HT29 CRC cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression. Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment. PMID: 27657827 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2016 Category: Drugs & Pharmacology Authors: Davudian S, Shajari N, Kazemi T, Mansoori B, Salehi S, Mohammadi A, Shanehbandi D, Shahgoli VK, Asadi M, Baradaran B Tags: Biomed Pharmacother Source Type: research

Metastasis associated in colon cancer 1 (MACC1) promotes growth and metastasis processes of colon cancer cells.
CONCLUSIONS: MACC1 promotes the growth and metastasis processes of CC cells. PMID: 27424982 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 21, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Effects of HMGA2 siRNA and doxorubicin dual delivery by chitosan nanoparticles on cytotoxicity and gene expression of HT‐29 colorectal cancer cell line
ConclusionIn conclusion, our results revealed that dual delivery of a key gene siRNA and appropriate anticancer drug have great impact on the treatment of colorectal cancer.
Source: Journal of Pharmacy and Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Authors: Homayoon Siahmansouri, Mohammad Hossein Somi, Zohreh Babaloo, Behzad Baradaran, Farhad Jadidi‐Niaragh, Fatemeh Atyabi, Hamed Mohammadi, Majid Ahmadi, Mehdi Yousefi Tags: Research Paper Source Type: research

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.
Abstract Deregulation of the ubiquitin-proteasome pathway has been frequently observed in a number of malignancies. Using quantitative Western blotting of normal and matched tumour tissue, we here identified a significant increase in the 19S proteasome subunit Rpt4 in response to chemoradiation in locally advanced rectal cancer patients with unfavourable outcome. We therefore explored the potential of Rpt4 reduction as a therapeutic strategy in colorectal cancer (CRC). Utilizing siRNA to down regulate Rpt4 expression, we show that silencing of Rpt4 reduced proteasomal activity and induced endoplasmic reticulum str...
Source: European Journal of Pharmacology - March 16, 2016 Category: Drugs & Pharmacology Authors: Boland K, Flanagan L, McCawley N, Pabari R, Kay EW, McNamara DA, Murray F, Byrne AT, Ramtoola Z, Concannon CG, Prehn JH Tags: Eur J Pharmacol Source Type: research

Retinoid N-(1H-benzodimidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells
Publication date: Available online 17 February 2016 Source:Steroids Author(s): Mine Mumcuoglu, A. Selen Gurkan-Alp, Erdem Buyukbingol, Rengul Cetin-Atalay Retinoids have been implicated as pharmacological agents for the prevention and treatment of various types of cancers, including breast cancers. We analysed 27 newly synthesized retinoids for their bioactivity on breast, liver, and colon cancer cells. Majority of the retinoids demonstrated selective bioactivity on breast cancer cells. Retinoid 17 had a significant inhibitory activity (IC50 3.5 μM) only on breast cancer cells while no growth inhibition observed wit...
Source: Steroids - February 19, 2016 Category: Drugs & Pharmacology Source Type: research

GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis
CONCLUSIONS AND IMPLICATIONSGPR55 is involved in the migratory behavior of colon carcinoma cells and may serve as a pharmacological target for the prevention of metastasis. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - October 5, 2015 Category: Drugs & Pharmacology Authors: J Kargl, L Andersen, C Hasenöhrl, D Feuersinger, A Stančić, A Fauland, C Magnes, A El‐Heliebi, S Lax, S Uranitsch, J Haybaeck, A Heinemann, R Schicho Tags: RESEARCH PAPER Source Type: research

Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
Abstract BI-69A11, novel Akt inhibitor, is currently drawing much attention due to its intriguing effect in inducing apoptosis in melanoma, breast, prostate and colon cancer. However, earlier reports reveal that PI3K/Akt/ mTOR inhibitors promote autophagy at the early stage as a survival mechanism that might affect its apoptotic potential. It is necessary to investigate whether BI-69A11 mediated apoptosis is associated with autophagy for enhancing its therapeutic efficacy. Here, we found that BI-69A11 induced autophagy at earlier time point through the inhibition of Akt/mTOR/p70S6kinase pathway. Dose-dependent and...
Source: European Journal of Pharmacology - August 22, 2015 Category: Drugs & Pharmacology Authors: Pal I, Parida S, Prashanth Kumar BN, Banik P, Kumar Dey K, Chakraborty S, Bhutia SK, Mandal M Tags: Eur J Pharmacol Source Type: research

miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells
Publication date: May 2015 Source:Biomedicine & Pharmacotherapy, Volume 72 Author(s): Wen-long Liang , Jie Cao , Bo Xu , Ping Yang , Fei Shen , Zheng Sun , Wang-lin Li , Qiang Wang , Feng Liu Colorectal cancer (CRC) is one of the most common malignancy cancers in the world. Aberrant microRNA expression is involved in human diseases including cancer. In the present study, we investigated the miR-892a's role in CRC cell proliferation. We found that miR-892a was frequently upregulated in human colorectal cancer tissues and cell lines compared with the matched tumor adjacent tissues and normal colonic cell line FHC. ...
Source: Biomedicine and Pharmacotherapy - June 20, 2015 Category: Drugs & Pharmacology Source Type: research

miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells.
Abstract Colorectal cancer (CRC) is one of the most common malignancy cancers in the world. Aberrant microRNA expression is involved in human diseases including cancer. In the present study, we investigated the miR-892a's role in CRC cell proliferation. We found that miR-892a was frequently upregulated in human colorectal cancer tissues and cell lines compared with the matched tumor adjacent tissues and normal colonic cell line FHC. Overexpression of miR-892a promoted cell proliferation and colony formation of CRC. Bioinformatics analysis further revealed PPP2R2A was identified as a potential miR-892a. Overexpress...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2015 Category: Drugs & Pharmacology Authors: Liang WL, Cao J, Xu B, Yang P, Shen F, Sun Z, Li WL, Wang Q, Liu F Tags: Biomed Pharmacother Source Type: research

EGCG Synergizes the Therapeutic Effect of Cisplatin and Oxaliplatin through Autophagic Pathway in Human Colorectal Cancer Cells
In this study we used synergistic strategies by combining (-)-Epigallocatechin gallate (EGCG) with cisplatin or oxaliplatin to minimize the ill effects of platinium-based therapy. MTS assay was used to examine the effect of EGCG, cisplatin and oxaliplatin on the proliferation of human colorectal cancer DLD-1 and HT-29 cells. Autophagic process was evaluated by detection of LC3-II protein, autophagosome formation, and quantification of Acidic Vesicular. Treatment of DLD-1 and HT-29 cells with EGCG plus cisplatin or oxaliplatin showed a synergistic effect on inhibition of cell proliferation and induction of cell death. EGCG ...
Source: Journal of Pharmacological Sciences - April 15, 2015 Category: Drugs & Pharmacology Source Type: research

Single-walled carbon nanotubes functionalized with aptamer and piperazine–polyethylenimine derivative for targeted siRNA delivery into breast cancer cells
In this study, we used a RNA aptamer against EpCAM (EpDT3) attached physically to our newly synthesized non-viral vector, based on single-walled carbon nanotube (SWNT) conjugated to piperazine–polyethylenimine derivative. The DNA transfection efficiency and siRNA delivery activity of the synthesized vector was investigated against upregulated BCL9l, which has been associated with breast and colorectal cancers. The complexes of the vector–aptamer/siRNA could specifically induce apoptosis by more than 20% in MCF-7 cell line as a positive EpCAM than MDA-MB-231 cells which are EpCAM negative. The decrease of BCL9l protein ...
Source: International Journal of Pharmaceutics - March 11, 2015 Category: Drugs & Pharmacology Source Type: research

Cellular density‐dependent down‐regulation of EP4 prostanoid receptors via the up‐regulation of hypoxia‐inducible factor‐1α in HCA‐7 human colon cancer cells
Abstract Increases in prostaglandin E2 (PGE2) and cyclooxygenase‐2 (COX‐2) levels are features of colon cancer. Among the different E‐type prostanoid receptor subtypes, EP4 receptors are considered to play a crucial role in carcinogenesis by, for example, inducing COX‐2 when stimulated with PGE2. However, EP4 receptor levels and PGE2‐induced cellular responses are inconsistent among the cellular conditions. Therefore, the connections responsible for the expression of EP4 receptors were investigated in the present study by focusing on cell density‐induced hypoxia‐inducible factor‐1α (HIF‐1α). The express...
Source: Pharmacology Research and Perspectives - November 7, 2014 Category: Drugs & Pharmacology Authors: Sho Otake, Kenji Yoshida, Naofumi Seira, Christopher M. Sanchez, John W. Regan, Hiromichi Fujino, Toshihiko Murayama Tags: Original Article Source Type: research

Influence of UGT1A1 gene methylation level in colorectal cancer cells on the sensitivity of the chemotherapy drug CPT-11
Conclusions The cytotoxicity of CPT-11 to colorectal cancer cells has a negative correlation with UGT1A1 expression, and positive correlation with CES2 and GUSB. The specific silencing UGT1A1 gene of siRNA could significantly increase the sensitivity of CPT-11 to the chemotherapy of colorectal cancer cells. UGT1A1 methylation was an important factor affecting the chemosensitivity of CPT-11.
Source: Biomedicine and Pharmacotherapy - November 1, 2014 Category: Drugs & Pharmacology Source Type: research

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