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Total 198 results found since Jan 2013.

A survey of reporting of colorectal cancer in Scotland: compliance with guidelines and effect of proforma reporting
Conclusions Significant differences exist in the frequencies with which important adverse prognostic features are reported by pathologists across 10 Scottish health boards. This has potential implications for patient care. Health boards that make routine use of reporting proformas are more likely to meet RCPath guidelines for reporting of these important pathological parameters.
Source: Journal of Clinical Pathology - May 17, 2014 Category: Pathology Authors: Woods, Y. L., Mukhtar, S., McClements, P., Lang, J., Steele, R. J., Carey, F. A. Tags: Immunology (including allergy), Colon cancer Original article Source Type: research

Extensive scheduled CT and CEA follow-up are equivalent in detecting recurrent colorectal cancer that is surgically treatable with curative intent, and superior to minimal follow up
Commentary on: Primrose JN, Perera R, Gray A, et al.; FACS Trial Investigators. Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomised clinical trial. JAMA 2014;311:263–70. Context Recurrence after attempted curative colorectal cancer surgery remains problematic with up to 50% developing metastases by 5 years.1 More aggressive surgical approaches likely improve prognosis,2 and there is a reasonable assumption that early detection by intensive patient follow-up improves outcomes. Two meta-analysis suggest regular measurement of carcinoembryonic anti...
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Taylor, S. A. Tags: Epidemiologic studies, Immunology (including allergy), Screening (oncology), Radiology, Clinical diagnostic tests, Radiology (diagnostics) Prevention Source Type: research

Assessment of cancer risk with {beta}-interferon treatment for multiple sclerosis
Conclusions There was no evidence of an increased cancer risk with exposure to IFNβ over a 12-year observation period. However, the trend towards an association between IFNβ and breast cancer should be investigated further.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Kingwell, E., Evans, C., Zhu, F., Oger, J., Hashimoto, S., Tremlett, H. Tags: Immunology (including allergy), Multiple sclerosis Source Type: research

Hypersensitivity reactions to racemic calcium folinate (leucovorin) during FOLFOX and FOLFIRI chemotherapy administrations
Hypersensitivity reactions (HSRs) to antineoplastic agents are an increasingly important problem, and some patients may be doomed to therapy discontinuation for fear of inducing severe reactions.1 HSRs to oxaliplatin have been reported, with the incidence ranging from 12% to 17%,1 whereas very few cases of folinic acid HSRs have been reported.2 Folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) and folinic acid, 5-fluorouracil, and irinotecan (FOLFIRI) regimes are used in colorectal cancer treatment.
Source: Journal of Allergy and Clinical Immunology - November 7, 2014 Category: Allergy & Immunology Authors: Alicia Ureña-Tavera, Miriam Zamora-Verduga, Ricardo Madrigal-Burgaleta, Denisse Angel-Pereira, Maria Pilar Berges-Gimeno, Emilio Alvarez-Cuesta Tags: Letter to the Editor Source Type: research

Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis.
Abstract The pool of microbes inhabiting our body is known as "microbiota" and their collective genomes as "microbiome". The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition (dysbiosis), function, or microbiota-h...
Source: World Journal of Gastroenterology : WJG - November 7, 2014 Category: Gastroenterology Authors: Tojo R, Suárez A, Clemente MG, de Los Reyes-Gavilán CG, Margolles A, Gueimonde M, Ruas-Madiedo P Tags: World J Gastroenterol Source Type: research

Is neuroendocrine differentiation useful to discriminate primary sinonasal intestinal-type adenocarcinomas from metastatic colorectal adenocarcinomas?
In conclusion, presence of neuroendocrine cells seems more in favour of a sinonasal intestinal-type adenocarcinoma, than metastatic CRA. This immunohistochemical study could be useful in difficult cases and should be an interesting complement in a clinical discussion.
Source: Journal of Clinical Pathology - December 16, 2014 Category: Pathology Authors: Projetti, F., Serrano, E., Vergez, S., Bissainthe, A.-C., Delisle, M.-B., Uro-Coste, E. Tags: Immunology (including allergy), Colon cancer Short report Source Type: research

KRAS mutation status impacts diagnosis and treatment decision in a patient with two colon tumours: a case report
KRAS mutation status predicts response to anti-EGFR therapy in colorectal cancer patients. Here we report an interesting case of discordant KRAS mutation status in a patient with two separate tumour foci. Tumour A in sigmoid colon invaded through muscularis propria into the subserosal fat with metastatic disease in regional lymph nodes (pT3N2b). Tumour B in ascending colon had a relatively lower stage and no metastasis (pT2N0). Both tumours showed similar morphology, immunohistochemical staining and microsatellite instability pattern. KRAS mutation, however, was detected only in tumour A. These findings indicate distinct c...
Source: Journal of Clinical Pathology - December 16, 2014 Category: Pathology Authors: Li, X., Pezeshkpour, G., Phan, R. T. Tags: Immunology (including allergy), Colon cancer Short report Source Type: research

Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that? We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news

Comprehensive lymph node morphometry in rectal cancer using acetone compression
Conclusions AC does not alter LN morphology and is especially suited to retrieve small LN after neoadjuvant CRT of rectal cancer. Neoadjuvant multimodality treatment caused reduced LN sizes while the LN numbers were not affected. When compared with MD, AC proved more reliable in the retrieval of LN from rectal cancer specimens after neoCRT.
Source: Journal of Clinical Pathology - May 18, 2015 Category: Pathology Authors: Scheel, A. H., Reineke, R. A., Sprenger, T., Lokka, S., Kitz, J., Ghadimi, B. M., Ruschoff, J., Liersch, T., Middel, P. Tags: Immunology (including allergy), Colon cancer Original article Source Type: research

Atopic Allergic Conditions and Colorectal Cancer Risk in the Multiethnic Cohort Study
We examined the association between AACs (asthma, hay fever, or allergy) and CRC among white, African-American, Native Hawaiian, Japanese-American, and Latino men and women in the Multiethnic Cohort Study within Hawaii and Los Angeles, California. The prospective analysis included 4,834 incident CRC cases and 1,363 CRC-related deaths ascertained between 1993 and 2010. We examined associations by ethnicity, location, stage, and potential effect modification by CRC risk factors. AACs were associated with a reduced risk of CRC incidence among both men and women (relative risk (RR) = 0.86, 95% confidence interval (CI): 0.80, 0...
Source: American Journal of Epidemiology - May 27, 2015 Category: Epidemiology Authors: Tambe, N. A., Wilkens, L. R., Wan, P., Stram, D. O., Gilliland, F., Park, S. L., Cozen, W., Martinez-Maza, O., Le Marchand, L., Henderson, B. E., Haiman, C. A. Tags: RESEARCH-ARTICLE Source Type: research

My Body Makes My Brain Look Like an Idiot...
I'm getting older. I hurt more. I creak more. My ankles sound like they're each having their own personal fireworks display every single morning when I walk downstairs to feed the dog. He's getting old, too. We commiserate. "Another gray hair?" I tease. "Pot, meet kettle," he'd respond if he could. Touché, Bear. Each day brings a new malady, depending on what I eat, how I exercise, how much sleep I get, or if I have one too many glasses of wine. My liver has given up having even a shred of compassion for my unintelligence. And for some reason, my allergies whalloped me very hard this year. I can tolerate almost anythi...
Source: Healthy Living - The Huffington Post - June 16, 2015 Category: Consumer Health News Source Type: news

Blood and lymphatic vessel invasion in pT1 colorectal cancer: an international concordance study
Conclusions A uniform criterion strongly influences the diagnostic consistency of BLI but may not always improve the concordance. Further study is required to achieve an objective diagnosis of BLI in colorectal cancer. The varying effects of diagnostic criterion on the pathologists from Japan, the USA/Canada and Europe might reflect varied interpretations of the criterion. Internationally accepted criterion should be developed by participants from around the world.
Source: Journal of Clinical Pathology - July 20, 2015 Category: Pathology Authors: Kojima, M., Puppa, G., Kirsch, R., Basturk, O., Frankel, W. L., Vieth, M., Lugli, A., Sheahan, K., Yeh, M., Lauwers, G. Y., Risio, M., Shimazaki, H., Iwaya, K., Kage, M., Akiba, J., Ohkura, Y., Horiguchi, S., Shomori, K., Kushima, R., Nomura, S., Ajioka, Tags: Immunology (including allergy), Colon cancer Original article Source Type: research

Grading lymph node metastasis: a feasible approach for prognostication of patients with stage III colorectal cancer
In conclusion, lymph node grade emerged as a promising novel prognostic variable for patients with AJCC/UICC stage III disease. Additional studies are warranted to validate this new finding.
Source: Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Resch, A., Harbaum, L., Pollheimer, M. J., Kornprat, P., Lindtner, R. A., Langner, C. Tags: Immunology (including allergy), Colon cancer Short report Source Type: research

Microbiome May Predict Colon Cancer Tumor Mutational StatusMicrobiome May Predict Colon Cancer Tumor Mutational Status
The characterization of the microbiome of a tumor can be used to predict the presence of a specific mutation, new research shows. Medscape Medical News
Source: Medscape Allergy Headlines - October 13, 2015 Category: Allergy & Immunology Tags: Pathology & Lab Medicine News Source Type: news

Constitutional mismatch repair deficiency syndrome: clinical description in a French cohort
Conclusions In conclusion, this unselected series of patients confirms the extreme severity of this syndrome with a high mortality rate mostly related to multiple childhood cancers, and highlights the need for its early detection in order to adapt treatment and surveillance.
Source: Journal of Medical Genetics - October 22, 2015 Category: Genetics & Stem Cells Authors: Lavoine, N., Colas, C., Muleris, M., Bodo, S., Duval, A., Entz-Werle, N., Coulet, F., Cabaret, O., Andreiuolo, F., Charpy, C., Sebille, G., Wang, Q., Lejeune, S., Buisine, M. P., Leroux, D., Couillault, G., Leverger, G., Fricker, J. P., Guimbaud, R., Math Tags: Immunology (including allergy), Neurooncology, CNS cancer, Colon cancer, Paediatric oncology, Epidemiology Cancer genetics Source Type: research