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PNR Weekly Digest: March 30, 2021
Items regarding COVID-19 information are indicated with an * In the Dragonfly: *NNLM Covid-19 Symposium. Keynote Speakers Announced. Registration is Open The Network of the National Library of Medicine (NNLM) is excited to announce a new, free virtual symposium focused on addressing the COVID-19 infodemic in our communities. The NNLM Virtual Symposium: Responding to the COVID-19 Infodemic is an opportunity to address misinformation and mistrust, raise awareness about the pandemic, and efforts to combat it. Symposium attendees can expect to come away from the 2-day experience with a better understanding of COVID-19 and shar...
Source: Dragonfly - March 30, 2021 Category: Databases & Libraries Authors: Carolyn Martin Tags: PNR Weekly Digest Source Type: news

Screening For Colorectal Cancer in the Age of Simulation Models: A Historical Lens
In late March, The Washington Post, citing unnamed officials, quoted Dr Anthony S. Fauci ’s response to the demands of modeling the novel coronavirus epidemic: “I’ve looked at all the models. I’ve spent a lot of time on the models. They don’t tell you anything. You can’t really rely upon models.”1 The provocative claim from the Director of the National Institute of Allergy and Infectious Diseases was quickly seized upon by critics of the Coronavirus Task Force’s recommendations. Simulation models, however, are certainly not new and have played a prominent role in epidemiology for many decades.
Source: Gastroenterology - July 15, 2020 Category: Gastroenterology Authors: Christopher J. Phillips, Robert E. Schoen Tags: Commentary Source Type: research

Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
Discussion Tibroviruses are highly undercharacterized rhabdoviruses with unknown pathogenic potential. All isolated tibroviruses (BAV, BHV, CPV, SWBV, and TIBV) have only been found in biting midge vectors or in various, apparently healthy non-human mammals (Cybinski et al., 1980; Standfast et al., 1984; Cybinski and Gard, 1986; Gibbs et al., 1989). The discovery of BASV, EKV-1, and EKV-2 genomes in human sera (Grard et al., 2012; Stremlau et al., 2015) suggests that at least some tibroviruses could infect humans. Because BASV was discovered in the serum of a severely ill individual, tibroviruses should be considered pote...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Exploration of (hetero)aryl derived thienylchalcones for antiviral and anticancer activities.
CONCLUSION: Compounds V and VI were demonstrated viral inhibition towards Human cytomegalovirus, whereas cyclopropylquinoline derivative IV towards Rift Valley fever virus and Tacaribe virus. Additionally, cyclopropylquinoline derivative IV has displayed very good cytotoxicity against colon, breast and leukemia cell lines in vitro. PMID: 29792154 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - May 23, 2018 Category: Chemistry Authors: Patil V, Patil SA, Patil R, Bugarin A, Beaman K, Patil SA Tags: Med Chem Source Type: research