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Condition: Lynch Syndrome
Cancer: Colorectal Cancer

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Total 319 results found since Jan 2013.

Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-associated Immunity in Lynch Syndrome
CONCLUSIONS: Together these data have important implications for cancer interception in LS, and document for the first-time biological effects of exercise in the immune system of a target organ in patients at-risk for cancer.PMID:37724990 | DOI:10.1158/1078-0432.CCR-23-0088
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Nan Deng Laura Reyes-Uribe Johannes F Fahrmann Whittney S Thoman Mark F Munsell Jennifer B Dennison Eunice Murage Ranran Wu Ernest T Hawk Selvi Thirumurthi Patrick M Lynch Christina M Dieli-Conwright Alexander J Lazar Sonali Jindal Khoi Chu Manoj Chelvana Source Type: research

A Novel Mutation of < em > MSH2 < /em > Gene in a Patient with Lynch Syndrome Presenting with Thirteen Metachronous Malignancies
J Clin Med. 2023 Aug 24;12(17):5502. doi: 10.3390/jcm12175502.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), accounts for 2-3% of all colorectal cancers. This autosomal dominant disorder is associated with a predisposition to endometrial, stomach, small bowel, pancreatic, biliary tract, ovary, urinary tract, brain, and skin tumors. Lynch syndrome is caused by the mutation of the MLH1, MSH2 (EPCAM), MSH6, and PMS2 genes. In this article, a case study of a 70-year-old female patient with Lynch syndrome is presented. Over a span of 30 years, the patient underwent multiple surgica...
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Ugne Silinskaite Edita Gavelien ė Rokas Stulpinas Ramunas Janavicius Tomas Poskus Source Type: research

Development of an Electronic Health Record-Based Clinical Decision Support Tool for Patients With Lynch Syndrome
CONCLUSION: We have successfully developed an EHR-based CDS tool to promote guideline-recommended cancer risk management among patients with LS.PMID:37639653 | DOI:10.1200/CCI.23.00024
Source: Clinical Colorectal Cancer - August 28, 2023 Category: Cancer & Oncology Authors: Kelsey S Lau-Min Joseph Bleznuck Colin Wollack Danielle B McKenna Jessica M Long Anna P Hubert Mariah Johnson Shavon E Rochester Gillain Constantino Christina Dudzik Abigail Doucette Kirk Wangensteen Susan M Domchek Jeffrey Landgraf Jessica Chen Katherine Source Type: research

Cancers, Vol. 15, Pages 4245: Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers
rnero Élez Microsatellite instability (MSI) is a biological condition associated with inflamed tumors, high tumor mutational burden (TMB), and responses to immune checkpoint inhibitors. In colorectal cancer (CRC), MSI tumors are found in 5% of patients in the metastatic setting and 15% in early-stage disease. Following the impressive clinical activity of immune checkpoint inhibitors in the metastatic setting, associated with deep and long-lasting responses, the development of immune checkpoint inhibitors has expanded to early-stage disease. Several phase II trials have demonstrated a high rate of pathological compl...
Source: Cancers - August 24, 2023 Category: Cancer & Oncology Authors: Ros Baraibar Saoudi Rodriguez Salv à Tabernero Élez Tags: Review Source Type: research

Familial intestinal polyposis and device assisted enteroscopy: where do we stand?
Expert Rev Gastroenterol Hepatol. 2023 Jul 29:1-6. doi: 10.1080/17474124.2023.2242240. Online ahead of print.ABSTRACTINTRODUCTION: Hereditary polyposis syndromes are a group of inherited disorders associated with a high risk of developing colorectal cancer. The best known ones are familial adenomatous polyposis (FAP), Peutz-Jeghers (PJS), juvenile polyposis and Cowden syndromes, as well as conditions predisposing to cancer, such as Lynch syndrome. Some of them are characterized by an increased risk of small bowel polyps occurrence.AREAS COVERED: Literature search in PubMed was performed in November 2022 and a narrative rev...
Source: Expert Review of Gastroenterology and Hepatology - July 29, 2023 Category: Gastroenterology Authors: Giuseppe Losurdo Milena Di Leo Salvatore Rizzi Ilaria Lacavalla Francesca Celiberto Andrea Iannone Maria Rendina Enzo Ierardi Giuseppe Iabichino Luca De Luca Alfredo Di Leo Source Type: research

Accidental insertion of double-J in the inferior vena cava in a patient with retroperitoneal fibrosis: a case report
CONCLUSIONS: Situations such as this require caution during the implantation of the drainage device, with the occurrence of resistance indicating the need to discontinue the procedure and perform a new assessment with imaging exams. No intraoperative or postoperative complications occurred and the patient is currently in outpatient follow-up.PMID:37492792 | PMC:PMC10364004 | DOI:10.21037/acr-22-93
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: Jo ão Henrique Godoy Rodrigues Murillo de Souza Tuckumantel Lu ís Cesar Fava Spessoto Fernando Nestor Facio Source Type: research

Serum matrix metalloproteinase-7: a potential biomarker in patients with Lynch Syndrome
CONCLUSIONS: Age-adjusted serum MMP-7 levels in asymptomatic LS carriers are higher than its levels in healthy population. While in colon cancer, MMP-7 higher level probably reflects the tumor burden and may have a prognostic effect, its significance and clinical applicability as a biomarker for tumorigenesis in LS is less clear and should be elucidated.PMID:37480510 | DOI:10.1007/s11033-023-08614-y
Source: Molecular Biology Reports - July 22, 2023 Category: Molecular Biology Authors: Doron Yablecovitch Hussein Mahajna Nir Horesh Efraim Katz Orit Picard Miri Yavzori Ella Fudim Talia Saker Shomron Ben-Horin Ido Laish Source Type: research