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Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer
CONCLUSION: Compared to the Leptin-treated mDC and LPS-treated mDC vaccines, the Leptin/LPS-treated mDC vaccine was more effective in inhibiting BC development and boosting immune responses against tumor.PMID:37647347 | DOI:10.1080/08923973.2023.2253989
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Pedram Basirjafar Raziyeh Zandvakili Javad Masoumi Nahid Zainodini Zahra Taghipour Hossein Khorramdelazad Soheila Yousefi Tayyebeh Tavakoli Mahboobeh Vatanparast Sepehr Safdel Mahsa Gheitasi Fatemeh Ayoobi Bahar Naseri Abdollah Jafarzadeh Source Type: research

Novel phenanthrene imidazoles as telomeric G-quadruplex ligands trigger potent immunogenic cell death in triple-negative breast cancer
In this study, we rationally designed and synthesized a series of novel phenanthrene imidazoles targeting telomeric G4. Among them, PI-2 was identified as the most promising ligand with high cytotoxicity, cellular uptake efficiency and G4-interacting ability. Cellular studies indicated that PI-2 inhibited the proliferation and migration of both human and mouse triple-negative breast cancer (TNBC) cells. PI-2 triggered the occurrence of DDR and ICD, where the related pathways were further decided. In vivo experiments displayed that PI-2-treated dying cells could be an effective vaccination to reduce tumor burden and promote...
Source: International Journal of Biological Macromolecules - July 31, 2023 Category: Biochemistry Authors: Xiao-Dong Wang Jia-Xin Wang Ming-Hao Hu Source Type: research

rWTC-MBTA: autologous vaccine prevents metastases via antitumor immune responses
CONCLUSION: The rWTC-MBTA vaccine demonstrated efficacy in multiple animal models through T-cell mediated cytotoxicity and has potential as a therapeutic option for preventing and treating tumor metastasis with minimal systemic toxicity.PMID:37434263 | DOI:10.1186/s13046-023-02744-8
Source: Clinical Breast Cancer - July 11, 2023 Category: Cancer & Oncology Authors: Juan Ye Herui Wang Rogelio Medina Samik Chakraborty Mitchell Sun Alex Valenzuela Xueyu Sang Yaping Zhang Ondrej Uher Jan Zenka Karel Pacak Zhengping Zhuang Source Type: research

The Oncolytic herpes simplex virus type-1 (HSV-1) vaccine strain VC2 causes intratumor infiltration of functionally active T cells and inhibition of tumor metastasis and pro-tumor genes VEGF and PDL1 expression in the 4T1/Balb/c mouse model of stage four breast cancer
Conclusion: These results show that VC2 therapy can improve anti-tumor response associated with a better control of tumor metastasis. improve T cell responses and reduce pro-tumor biomarker gene transcription. VC2 holds promise for further development as an oncolytic and immunotherapeutic approach to treat breast and other cancers.PMID:37388243 | PMC:PMC10303929 | DOI:10.3389/fmolb.2023.1199068
Source: Herpes - June 30, 2023 Category: Infectious Diseases Authors: Rafiq Nabi Farhana Musarrat Jose Cesar Menk P Lima Ingeborg M Langohr Vladimir N Chouljenko Konstantin G Kousoulas Source Type: research

Vaccination with celecoxib-treated dendritic cells improved cellular immune responses in an animal breast cancer model
CONCLUSIONS: Our findings show that LPS/CXB-treated DC vaccine potently modulated antitumor immune responses in a mouse BC model.PMID:37003235 | DOI:10.1016/j.advms.2023.03.002
Source: Advances in Medical Sciences - April 1, 2023 Category: Biomedical Science Authors: Raziyeh Zandvakili Pedram Basirjafar Javad Masoumi Nahid Zainodini Zahra Taghipour Hossein Khorramdelazad Soheila Yousefi Tayyebeh Tavakoli Sepehr Safdel Mahsa Gheitasi Fatemeh Ayoobi Abdollah Jafarzadeh Source Type: research

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