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Total 677 results found since Jan 2013.

Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors
ConclusionExtreme adiposity and any elevation in WC increased risk of CVD among breast cancer survivors; however, changes in weight in the early post-diagnosis period were not associated with CVD. Survivors with high WC and existing CVD risk factors should be monitored.
Source: Breast Cancer Research and Treatment - February 6, 2017 Category: Cancer & Oncology Source Type: research

Patient-centered Outcomes with Concomitant Use of Proton Pump Inhibitors and Other Drugs.
Abstract PURPOSE: We performed a systematic review of patient-centered outcomes after the concomitant use of proton pump inhibitors (PPIs) and other drugs. METHODS: We searched 4 databases in July 2016 to find studies that reported mortality and morbidity after the concomitant use of PPIs and other drugs. We conducted direct meta-analyses using a random-effects model and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation working group approach. FINDINGS: We included data from 17 systematic reviews and meta-analyses, 16 randomized controlled t...
Source: Clinical Therapeutics - February 8, 2017 Category: Drugs & Pharmacology Authors: Shamliyan TA, Middleton M, Borst C Tags: Clin Ther Source Type: research

Exercise 'most proven method' to prevent return of breast cancer
Conclusion This was a helpful summary of recent research into how lifestyle changes impact on the risk of breast cancer returning, but it does have some limitations. Researching lifestyle factors separately is always difficult as they tend to clump together, making it difficult to pick apart individual factors. For example, people who are more physically active tend to have a healthier diet and are less likely to drink excessive amounts of alcohol or smoke. While the researchers say many studies attempt to make adjustments for these confounding factors, it is difficult to know which studies did this and how successful they...
Source: NHS News Feed - February 22, 2017 Category: Consumer Health News Tags: Cancer QA articles Lifestyle/exercise Source Type: news

Abstract PD4-07: Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population study
Conclusions: The occurrence of MI is very low in this cohort (4.4%), reassuring the clinicians that the older adults with comorbidities may not be at a higher risk of MI with adjuvant endocrine therapy. However, the confidence interval for the hazard ratio of AIs vs Tamoxifen is very wide, indicating that a larger sample may be needed for the power of the study to be conclusive.Citation Format: Kamaraju S, Smith E, Shi Y, Laud P, Neuner J. Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population study [abstract]. In: Proceedings of the Thirty-Ninth Annual C...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: S Kamaraju, E Smith, Y Shi, P Laud, J Neuner Tags: Poster Discussion Abstracts Source Type: research

Abstract P2-01-23: Long-term follow-up of persistent breast dermopigmentation after sentinel lymph node identification using superparamagnetic iron oxide particles (SIENNA+(R))
Patients with breast cancer (BC) and those at high risk for BC are often reluctant to initiate Tamoxifen (Tam) due to potential adverse events (AEs) such as deep vein thrombosis (DVT), pulmonary embolus (PE), acute ischemic stroke (AIS), myocardial infarction (MI) and endometrial cancer (EC). Some decline this life saving therapy due to fear of AEs. AE rates from RCTs are low, but AE rates in the general population are not well documented.Methods: The MarketScanR database (2010-2013) was searched for patients aged 30-64 with a prescription of Tam active for more than 120 days. Patients with prior DVT, PE, AIS, MI or EC wer...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: K Hannebicque, L Boulanger, E Bogart, S Giard, MP Chauvet, JL Houpeau Tags: Poster Session Abstracts Source Type: research

Abstract P5-08-06: Impact of a decision-support tool on the utilization of colony-stimulating factors and incidence of febrile neutropenia among patients with breast cancer
High rates of overweight/obesity are commonly seen in breast cancer (BC) survivors. Observational data show an association between post-treatment increased weight and lack of physical activity (PA) and risk of BC recurrence and death. Increases in prognostic inflammatory associated biomarkers (BM) such as interleukin-6 (IL6) and C-reactive protein (CRP), and their downstream effects, are linked to overweight/obesity and provide a potential mechanistic explanation for this increase in recurrence risk, but studies are mixed regarding the effect of lifestyle interventions on these BM. In addition, better BM may exist. The Get...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: G Adeboyeje, A Agiro, A Goodwin, A DeVries, J Malin Tags: Poster Session Abstracts Source Type: research

The Associations of Atrial Fibrillation With the Risks of Incident Invasive Breast and Colorectal Cancer
<span class="paragraphSection"><div class="boxTitle">Abstract</div>Atrial fibrillation (AF) is a common arrhythmia that poses a significant risk of stroke. Cross-sectional and case-control studies have shown evidence of associations between AF and breast or colorectal cancer, but there have been no longitudinal studies in which this has been assessed. We prospectively examined a cohort of 93,676 postmenopausal women enrolled in the Women's Health Initiative from 1994 to 1998 to determine whether there are relationships between baseline AF and the development of invasive breast or colorectal cancer. The pr...
Source: American Journal of Epidemiology - February 7, 2017 Category: Epidemiology Source Type: research

Phaleria macrocarpa (Boerl.) Fruit induce G0/G1 and G2/M cell cycle arrest and apoptosis through mitochondria-mediated pathway in MDA-MB-231 Human Breast Cancer Cell
Conclusion The results indicated that PMEAF treatment induced apoptosis in MDA-MB-231 cells through intrinsic mitochondrial related pathway with the participation of pro and anti-apoptotic proteins, caspases, G0/G1 and G2/M-phases cell cycle arrest by p53-mediated mechanism. Graphical abstract
Source: Journal of Ethnopharmacology - March 1, 2017 Category: Drugs & Pharmacology Source Type: research

Abstract P6-07-12: A physical activity and dietary counseling intervention in breast cancer survivors and changes in known and novel prognostic biomarkers
High rates of overweight/obesity are commonly seen in breast cancer (BC) survivors. Observational data show an association between post-treatment increased weight and lack of physical activity (PA) and risk of BC recurrence and death. Increases in prognostic inflammatory associated biomarkers (BM) such as interleukin-6 (IL6) and C-reactive protein (CRP), and their downstream effects, are linked to overweight/obesity and provide a potential mechanistic explanation for this increase in recurrence risk, but studies are mixed regarding the effect of lifestyle interventions on these BM. In addition, better BM may exist. The Get...
Source: Cancer Research - February 28, 2017 Category: Cancer & Oncology Authors: LL Peterson, ME Ford, MJ Gregoski, KD Knight, EJ Hilton, G Magwood, DP Turner Tags: Poster Session Abstracts Source Type: research

Mediterranean diet may reduce risk of form of breast cancer – study
Eating plenty of nuts, fruit and fish may cut risk of getting oestrogen-receptor-negative cancer, Dutch research findsFollowing aMediterranean diet could help reduce the risk of contracting one of the worst types of breast cancer by 40%, according to a large study for the World Cancer Research Fund.The Mediterranean diet, which is rich in olive oil, fish, fruit, nuts, vegetables and wholegrains, has well-publicised benefits, includingreducing the risk of stroke and heart disease.Continue reading...
Source: Guardian Unlimited Science - March 6, 2017 Category: Science Authors: Haroon Siddique Tags: Breast cancer Cancer research Health & wellbeing Diets and dieting Life and style Science Society Medical research Source Type: news

Work after age 65: A prospective study of Australian men and women
ConclusionThis study quantifies the importance of education and health factors in determining continued participation of Australian men and women in paid work in later life. These factors need to be considered for policies aiming to increase workforce participation beyond 65 years of age.
Source: Australasian Journal on Ageing - November 30, 2016 Category: Geriatrics Authors: Tazeen Majeed, Peta M Forder, Meredith Tavener, Kha Vo, Julie Byles Tags: Research Article Source Type: research

Work after age 65: A prospective study of Australian men and women.
CONCLUSION: This study quantifies the importance of education and health factors in determining continued participation of Australian men and women in paid work in later life. These factors need to be considered for policies aiming to increase workforce participation beyond 65 years of age. PMID: 28272777 [PubMed - as supplied by publisher]
Source: Australasian Journal on Ageing - March 7, 2017 Category: Geriatrics Authors: Majeed T, Forder PM, Tavener M, Vo K, Byles J Tags: Australas J Ageing Source Type: research

Mangosteen: The Cancer-Fighting Superfruit
  If you're a woman with a family history of breast cancer, your doctor may recommend you start taking a toxic chemo drug like tamoxifen to lower your risk of developing the disease. Even if you have no signs or symptoms of cancer. Tamoxifen is what's known as a chemopreventive agent. That's a fancy phrase that means it's something that prevents cancer from forming. But its track record isn't all that impressive. Trials found that for every 1,000 women who take the drugs, only 21 to 35 cases of cancer would be prevented. And the side effects are downright terrifying. Bone pain, blood clots, increas...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Anti-Aging Source Type: news

High Intensity Interval Training For Maximizing Health Outcomes
Regular physical activity or exercise training are important actions to improve cardiorespiratory fitness and maintain health throughout life. There is solid evidence that exercise is an effective preventative strategy against at least 25 medical conditions, including cardiovascular disease, stroke, hypertension, colon and breast cancer, and type 2 diabetes. Traditionally, endurance exercise training (ET) to improve health related outcomes has consisted of low- to moderate ET intensity. However, a growing body of evidence suggests that higher exercise intensities may be superior to moderate intensity for maximizing health outcomes.
Source: Progress in Cardiovascular Diseases - April 3, 2017 Category: Cardiology Authors: Trine Karlsen, Inger-Lise Aamot, Mark Haykowsky, Øivind Rognmo Source Type: research

MassDevice.com +5 | The top 5 medtech stories for April 11, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Stimwave wins Australian regulatory nod for Freedom SCS Stimwave Technologies said late last week it won approval from the Australian Therapeutic Goods Administration for its Freedom spinal cord stimulation system, and launched ...
Source: Mass Device - April 11, 2017 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news