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Selectivity of cation transport across lipid membranes by the antibiotic salinomycin
Biochim Biophys Acta Biomembr. 2023 Jun 3:184182. doi: 10.1016/j.bbamem.2023.184182. Online ahead of print.ABSTRACTThe ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding, the data on its ion selectivity, although being critical for its therapeutic activity, are rather scarce. In the present work, we studied the ability of salinomycin to exert cation/H+-exchange across artificial bilayer lipid membranes (BLM) by measuring electrical potential on planar BLM in the presence of a protonophore and fluorescence responses of the...
Source: Biochimica et Biophysica Acta - June 5, 2023 Category: Biochemistry Authors: Tatyana I Rokitskaya Alexander M Firsov Ljudmila S Khailova Elena A Kotova Yuri N Antonenko Source Type: research

Risk of Breast Cancer With Prolactin Elevating Antipsychotic Drugs: An Observational Study of US Women (Ages 18-64 Years)
CONCLUSIONS: In the largest study of antipsychotics taken by US women, a higher risk between antipsychotic drug use and increased risk for breast cancer was observed, with a differential higher association with antipsychotic categories that elevate prolactin. Our study confirms other recent observational studies of increased breast cancer risk with antipsychotics that elevate prolactin.PMID:34864772 | DOI:10.1097/JCP.0000000000001513
Source: Clinical Breast Cancer - December 5, 2021 Category: Cancer & Oncology Authors: Tahir Rahman John M Sahrmann Margaret A Olsen Katelin B Nickel J Phillip Miller Cynthia Ma Richard A Grucza Source Type: research

Zeolites as Carriers of Antitumor Ribonuclease Binase
In this study we tested the clinoptilolite, chabazite, and natrolite ability to be loaded by antitumor ribonuclease binase and the cytotoxicity of the obtained complexes. We found the optimal conditions for binase loading into zeolites and established the dynamic of its release. Cytotoxic effects of zeolite-binase complexes toward colorectal cancer Caco2 cells were characterized after 24 and 48 h of incubation with cells using MTT-test. Zeolites were toxic by itselfs and reduced cells viability by 30% (clinoptilolite), 40% (chabazite), and 70% (natrolite) after 48 h of incubation. Binase complexes with clinoptilolite as we...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Tamoxifen May Reduce Mania in Patients With Bipolar Disorder But Questions Remain
Tamoxifen, a medication commonly used to treat breast cancer, appears to hold some promise as a treatment for mania, according to asystematic review and meta-analysisappearing in theJournal of Psychopharmacology.Tamoxifen has been proposed as a treatment for bipolar disorder because it acts on cells in a way similar to lithium and valproate —both of which are effective medications for bipolar disorder. However, the current review found most studies focused on the effect of tamoxifen on mania, not on bipolar disorder, and its effects on depression are unknown.“Tamoxifen appears to be a promising potential treatment for ...
Source: Psychiatr News - February 15, 2019 Category: Psychiatry Tags: bipolar disorder depression Journal of Psychopharmacology literature search mania meta-analysis systematic review tamoxifen Source Type: research