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Cancer: Breast Cancer
Drug: Insulin
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Total 371 results found since Jan 2013.
Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Is Regulated by Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) and Inhibits Proliferation, Motility and Stem Cell Properties of Breast Invasive Carcinoma
CONCLUSION: We found that ACSM3 was regulated by IGF2BP3 and attenuated BRCA proliferation, invasion and stem cell properties. The role of ACSM3 in BRCA was first revealed, which provides a novel target for treatment.PMID:37625834
Source: Clinical Breast Cancer - August 25, 2023 Category: Cancer & Oncology Authors: Wenjing Zhu Xiuxing Wei Meijiao Fang Source Type: research
Greb1 Transiently Accelerates Pancreatic β-Cell Proliferation in Diabetic Mice Exposed to Estradiol
Am J Pathol. 2023 Aug;193(8):1081-1100. doi: 10.1016/j.ajpath.2023.04.012.ABSTRACTDecrease of pancreatic β cells leads to diabetes. In an inducible cAMP early suppressor (ICER-Iγ) transgenic mouse model of severe type 2 diabetes with reduced insulin production and depleted β cells, supplementation with high concentrations of 17β-estradiol (E2) markedly enhances β-cell proliferation and normalizes glucose levels. The current study explored the underlying mechanisms leading to a dynamic increase of β cells and pathologic changes in diabetic mice exposed to E2. Gene expression profiling of pancreatic islets of 6-month-o...
Source: The American Journal of Pathology - July 29, 2023 Category: Pathology Authors: Akari Inada Yohichi Yasunami Atsushi Yoshiki Yo-Ichi Nabeshima Oogi Inada Source Type: research
An overview of recent findings that shed light on the connection between fat and cancer
Endocr Metab Immune Disord Drug Targets. 2023 Jul 24. doi: 10.2174/1871530323666230724141942. Online ahead of print.ABSTRACTObesity and cancer have been found to have a direct link in epidemiological studies. Obesity raises the risk of cancer and associated chronic disorders. Furthermore, an imbalance of adipokines, like leptins, plays a crucial role in neoplasm pathogenesis, cell migration, and thereby, cancer metastasis. Also, leptin increases human epidermal growth factor receptor 2 (HER2) protein levels through the STAT3-mediated (signal transducer and activator of transcription) upregulation of heat shock protein (Hsp...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - July 25, 2023 Category: Endocrinology Authors: Parth Pandit Chaitanya Shirke Nirav Bhatia Angel Godad Sateesh Belemkar Jayshree Patel Sandip Zine Source Type: research
IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth
In this study, we identified the regulatory targets of IGF2BP3 in breast cancer MDA-MB-231 cells using RNA immunoprecipitation sequencing (RIP-seq) and high-throughput RNA-sequencing (RNA-seq). We discovered that these targets were enriched in the inflammatory response, endoplasmic reticulum stress, cell cycle, and cancer-related pathways, providing a new perspective for better understanding the functional mechanisms of IGF2BP3. Moreover, we identified that the epidermal growth factor receptor (EGFR), a downstream target, is regulated by IGF2BP3. IGF2BP3 binds to and protects EGFR mRNA from degradation and facilitates cell...
Source: Biochimica et Biophysica Acta - July 20, 2023 Category: Biochemistry Authors: Xintao Jing Cong Han Qian Li Fang Li Jinyuan Zhang Qiuyu Jiang Fei Zhao Chen Guo Jinfeng Chen Ting Jiang Xiaofei Wang Yanke Chen Chen Huang Source Type: research
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | DOI:10.1186/s12575-023-00212-3
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
