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Subsets of Idiopathic Inflammatory Myositis Enriched for Contemporaneous Cancer Relative to the General Population
ConclusionIn a tertiary referral center population, anti-TIF1 γ was most strongly associated with breast and ovarian cancer. Patients with anti-synthetase, anti-MDA5, or anti-HMGCR antibodies had the same cancer risk as the general population.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - July 25, 2022 Category: Rheumatology Authors: Christopher A. Mecoli, Tak Igusa, Mengkun Chen, Xing Yao Wang, Jemima Albayda, Julie J Paik, Eleni Tiniakou, Brittany Adler, Carrie Richardson, Will Kelly, Sonye Danoff, Andrew L. Mammen, Elizabeth A. Platz, Antony Rosen, Lisa Christopher †Tags: Full Length Source Type: research

Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling
In this study, we analyzed the function of Tinagl1 in skeletal muscle using knockout mice and cell experiments. Although primary myoblasts isolated from Tinagl1-decifient (Tinagl1-/-) mice differentiated into normal myotubes, and treatment with recombinant Tinagl1 did not affect the proliferation or differentiation of C2C12 myoblasts, Tinagl1-/- mice exhibited reduced body mass and calf muscle weights compared to the control group (Tinagl1flox/flox). Furthermore, Tinagl1-/- mice showed myofibers with centrally located nuclei, which is a morphological marker of regenerating muscle or myopathy. In addition, the capillary den...
Source: Cell Research - May 21, 2022 Category: Cytology Authors: Yoriko Sato Keisuke Kawashima Emiko Fukui Hiromichi Matsumoto Fumiaki Yoshizawa Yusuke Sato Source Type: research

Presence of anti-TIF-1 γ, anti-Ro52, anti-SSA/Ro60 and anti-Su/Ago2 antibodies in breast cancer: a cross-sectional study
CONCLUSIONS: Autoantibodies to TIF-1γ were found in two patients with breast cancer without dermatomyositis (DM). More common specificities were autoantibodies anti-SSA/Ro60, anti-Ro52/TRIM21 and anti-Su/Ago2. More studies are needed in order to establish the biological meaning of the presence of SARD-associated autoantibodies in breast cancer.PMID:33876712 | DOI:10.1080/08923973.2021.1910833
Source: Immunopharmacology and Immunotoxicology - April 20, 2021 Category: Allergy & Immunology Authors: M ónica Vázquez-Del Mercado Erika Aurora Mart ínez-García Adri án Daneri-Navarro Eduardo G ómez-Bañuelos Beatriz Teresita Mart ín-Márquez Oscar Pizano-Mart ínez Eduardo A Wilson-Manr íquez Esther Guadalupe Corona-S ánchez Efrain Chavarria-Avil Source Type: research

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications
Conclusion 18F-FDG PET/CT does not appear to be useful in cancer screening for AIM patients compared with conventional screening and carries potential harms associated with follow-up investigations. The risk of cancer in AIM differs by myositis-specific antibodies-defined subsets and cancer screening is likely to be indicated only in high-risk patients, particularly DM. These results, replicated in larger, multicentered studies, may carry significant consequences for optimal management of AIM and health resource utilization.
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Effects of a series of acidic drugs on L-lactic acid transport by the monocarboxylate transporters MCT1 and MCT4.
CONCLUSION: This inhibition may cause an accumulation of intracellular L-lactic acid leading to acidification and muscular disorders. PMID: 29521223 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - March 7, 2018 Category: Biotechnology Authors: Leung YH, Belanger F, Lu J, Turgeon J, Michaud V Tags: Curr Pharm Biotechnol Source Type: research

Anti-synthetase syndrome: anti-PL-7, anti-PL-12 and anti-EJ
CONCLUSIONS: ASS (anti-PL-7, PL-12 and EJ) was found to predominantly affect white women. Although the autoantibodies described in the present study are more related to pulmonary than joint involvement, our patients showed a significant percentage of both types of involvement and a high percentage of myopathy. We also observed a low mortality rate.
Source: Revista Brasileira de Reumatologia - November 15, 2013 Category: Rheumatology Source Type: research

Incidence of malignancies in biopsy-proven inflammatory myopathy
Conclusion: The prevalence of malignancy was very low in our cohort as compared to the studies from other countries. Breast cancer was the most common malignancy associated with DM. The type of associated malignancy was quite variable.
Source: Neurology India - April 29, 2013 Category: Neurology Authors: Meena A KannanC SundaramMegha UppinRukmini MridulaSheik Afshan JabeenRupam Borgohain Source Type: research