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Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Some types of vegetarian diet can raise heart disease risk
Conclusion This large pooled cohort study seems to demonstrate an association between a healthy plant-based diet and reduced risk of coronary heart disease, and an increased risk of heart disease with an unhealthy plant-based diet. This adds to the evidence base supporting the possible benefits of healthy plant-based diets in protecting against certain illnesses. However there are some limitations to the research: The cohort included only health professionals from the US so might not be representative of wider populations in the UK or elsewhere. The study can't provide information on the benefits or otherwise of this d...
Source: NHS News Feed - July 18, 2017 Category: Consumer Health News Tags: Food/diet Source Type: news