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EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice
J Biomed Res. 2022 Nov 28:1-15. doi: 10.7555/JBR.36.20220168. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A3 (EphA3) is a member of the largest subfamily of tyrosine kinase receptors-Eph receptors. Previous studies have shown that EphA3 is associated with tissue development. Recently, we have found that the expression of EphA3 is elevated in the hypothalamus of mice with diet-induced obesity (DIO). However, the role of EphA3 in hypothalamic-controlled energy metabolism remains unclear. In the current study, we demonstrated that the deletion of EphA3 in the hypothalamus by CRISPR/Cas9-med...
Source: Biomed Res - April 4, 2023 Category: Research Authors: Jubiao Zhang Yang Chen Lihong Yan Xin Zhang Xiaoyan Zheng Junxia Qi Fen Yang Juxue Li Source Type: research

The Mitochondrial NAD Kinase Functions as a Major Metabolic Regulator Upon Increased Energy Demand
In this study, we investigated the function and mechanistic basis by which MNADK regulates metabolic homeostasis. Generalized gene-set analysis by aggregating human patient genomic databases indicated that human MNADK common gene variants or decreased expression of the gene are significantly associated with the occurrence of type-2 diabetes, non-alcoholic fatty liver disease (NAFLD), or hepatocellular carcinoma (HCC). Ablation of the MNADK gene in mice led to decreased fat oxidation, coincident with increased respiratory exchange ratio (RER) and decreased energy expenditure upon energy demand triggered by endurance exercis...
Source: Molecular Medicine - August 9, 2022 Category: Molecular Biology Authors: Hyunbae Kim Zhiyao Fu Zhao Yang Zhenfeng Song El Hussain Shamsa Thangal Yumnamcha Shengyi Sun Wanqing Liu Ahmed S Ibrahim Nathan R Qi Ren Zhang Kezhong Zhang Source Type: research

Induction of lipid metabolism dysfunction, oxidative stress and inflammation response by tris(1-chloro-2-propyl)phosphate in larval/adult zebrafish
Environ Int. 2022 Jan 10;160:107081. doi: 10.1016/j.envint.2022.107081. Online ahead of print.ABSTRACTAs an important organophosphate flame retardant, tris(1-chloro-2-propyl)phosphate (TCPP) is ubiquitous in the environment leading to inevitable human exposure. However, there is a paucity of information regarding its acute/chronic effects on obesity, lipid homeostasis, and hepatocellular carcinoma, especially regarding the underlying molecular mechanisms in humans. Herein, we investigated the effects of TCPP exposure (5-25 mg/L) on lipid homeostasis in larval and adult zebrafish (Danio rerio). TCPP exposure caused remarkab...
Source: Environment International - January 12, 2022 Category: Environmental Health Authors: Jin Yan Zijia Zhao Min Xia Shuya Chen Xiancheng Wan Anfei He Guangyao Daniel Sheng Xuedong Wang Qiuhui Qian Huili Wang Source Type: research

The functional activity of the miR-1914-5p in lipid metabolism of the hepatocarcinoma cell line HepG2: a potential molecular tool for controlling hepatic cellular migration
Mol Biol Rep. 2021 Apr 28. doi: 10.1007/s11033-021-06364-3. Online ahead of print.ABSTRACTHepatocellular carcinoma is one of the most common types of cancer in the world with high mortality rate and new therapies that control of fatty acid metabolism may limit the proliferation of cancer cells. In the last two decades, the non-coding RNAs have been considered as promising molecular tools to treat diseases, because they are able to modulate gene expression and the metabolic routes; however, deep investigation of their mechanistic behavior in pathologies must be performed. Thus, our aim was to evaluate the modulatory effect ...
Source: Mol Biol Cell - April 28, 2021 Category: Molecular Biology Authors: Marina Bonfogo da Silveira Camila Cristiane Pansa Osmar Malaspina Karen C M Moraes Source Type: research

ASO Visual Abstract: End-of-Life Hospice Utilization and Medicare Expenditures Among Patients Dying from Hepatocellular Carcinoma
Ann Surg Oncol. 2021 Apr 16. doi: 10.1245/s10434-021-09971-3. Online ahead of print.NO ABSTRACTPMID:33861407 | DOI:10.1245/s10434-021-09971-3
Source: Ann Oncol - April 16, 2021 Category: Cancer & Oncology Authors: Daniel R Rice J Madison Hyer Adrian Diaz Timothy M Pawlik Source Type: research