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Cancer: Liver Cancer
Infectious Disease: Adenoviruses
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Total 72 results found since Jan 2013.
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway
EMBO Mol Med. 2023 Jun 5:e17230. doi: 10.15252/emmm.202217230. Online ahead of print.ABSTRACTObesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the underlying mechanisms are yet to be elucidated. Adeno-associated virus (AAV) frequently infects humans and has been widely used in gene therapy, but the risk of AAV infection such as HCC should be further evaluated. Here, we show that recombinant AAV injection caused liver injury, hepatic necroptosis, and HCC in db/db or high-fat diet-induced hyperglycemic and obese mice, but not in mice with only hyperglycemia or obesity. Prednisone administrati...
Source: Molecular Medicine - June 5, 2023 Category: Molecular Biology Authors: Yalan Cheng Zhentong Zhang Peidong Gao Hejin Lai Wuling Zhong Ning Feng Yale Yang Huimin Yu Yali Zhang Yumo Han Jieya Dong Zhishui He Rui Huang Qiwei Zhai Source Type: research
Vector-Mediated Cancer Gene Therapy Reduces Toxicity and Inhibition of Lung Carcinoma Growth in Nude Mice
Appl Biochem Biotechnol. 2023 Apr 29. doi: 10.1007/s12010-023-04463-4. Online ahead of print.ABSTRACTReplication-competent oncolytic adenovirus (TOA2) gene therapy is a recently introduced anti-tumor treatment regimen with superior results. The biodistribution studies of virus vector-based medicine seem more cautious and have been given much attention recently in terms of its quality and safety in preclinical trials. The current study determined the biodistribution and safety of a replication-competent adenovirus in different organs to predict its toxicity threshold. The present study has used TOA2, while biodistribution a...
Source: Applied Biochemistry and Biotechnology - April 29, 2023 Category: Biochemistry Authors: Ahmad Taha Khalaf Jun Wan Hu Wei Shen Fubing Jamaludin Zainol Samiah Yasmin Abdul Kadir Min Liang Source Type: research
ETS-1/c-Met drives resistance to sorafenib in hepatocellular carcinoma
CONCLUSION: c-Met overexpression and activation is an essential mechanism of sorafenib resistance in HCC. Combination therapy of sorafenib plus c-Met inhibitor overcame the resistance of sorafenib-targeted therapy for HCC.PMID:36915773 | PMC:PMC10006745
Source: Cell Research - March 14, 2023 Category: Cytology Authors: Yongfang Ma Xueke Liu Xiaolong Tang Source Type: research
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90 β
This study reveals a fundamental role of HSP90β in governing HCV IRES-mediated translation as well as hepatic inflammation, and celastrol as a novel inhibitor of HCV translation and associated inflammation by specifically targeting HSP90β, which could be developed as a lead for the treatment of HSP90β positive HCV-associated HCC.PMID:36882503 | DOI:10.1038/s41401-023-01067-w
Source: Acta Pharmacologica Sinica - March 7, 2023 Category: Drugs & Pharmacology Authors: Shao-Ru Chen Zheng-Qing Li Jun Xu Mo-Yu Ding Ya-Ming Shan Yung-Chi Cheng Gao-Xiao Zhang Ye-Wei Sun Yu-Qiang Wang Ying Wang Source Type: research
TREM2 knockdown improves the therapeutic effect of PD-1 blockade in hepatocellular carcinoma
Biochem Biophys Res Commun. 2022 Oct 25;636(Pt 1):140-146. doi: 10.1016/j.bbrc.2022.10.079. Online ahead of print.ABSTRACTTriggering receptor expressed on myeloid cells 2 (TREM2), which is typically expressed in microglia/macrophage, is a crucial receptor modulating the activation of immune cells. Recent single-cell RNA sequencing studies of the tumor microenvironment (TME) have found that TREM2 is highly expressed in several subgroups of tumor-associated macrophages (TAMs) with immunosuppressive activity. TREM2 knockout mice are more resistant to tumor growth than wild-type mice in multiple mice tumor models. But the func...
Source: Cell Research - November 4, 2022 Category: Cytology Authors: Qinyu Wang Kang Zheng Dong Tan Gang Liang Source Type: research
Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease
World J Gastroenterol. 2022 Sep 28;28(36):5280-5299. doi: 10.3748/wjg.v28.i36.5280.ABSTRACTAlcohol-associated liver disease (ALD) is a common chronic liver disease and major contributor to liver disease-related deaths worldwide. Despite its pre-valence, there are few effective pharmacological options for the severe stages of this disease. While much pre-clinical research attention is paid to drug development in ALD, many of these experimental therapeutics have limitations such as poor pharmacokinetics, poor efficacy, or off-target side effects due to systemic administration. One means of addressing these limitations is thr...
Source: World Journal of Gastroenterology - October 3, 2022 Category: Gastroenterology Authors: Jeffrey Barr Warner Steven Corrigan Guenthner Josiah Everett Hardesty Craig James McClain Dennis Ray Warner Irina Andreyevna Kirpich Source Type: research
